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Table 1 Characteristics according to the therapeutic strategy

From: Factors influencing the implementation of antibiotic de-escalation and impact of this strategy in critically ill patients

Characteristics All patients
(n = 229)
De-escalation
(n = 117)
No de-escalation
(n = 112)
P value
Age, years 59.5 ± 17.0 61.2 ± 17.3 57.7 ± 16.7 0.11
Sex, number (percentage)     0.04
   Male 131 (57.2) 62 (53) 69 (61.6)  
   Female 98 (42.8) 55 (47) 43 (38.4)  
McCabe score 1.1 ± 0.8 1.1 ± 0.8 1.1 ± 0.8 0.78
History of immunosuppression, number (percentage) 22 (9.6) 11 (9.4) 11 (9.8) 0.62
SAPS II 51 ± 19 51 ± 19 50 ± 18 0.77
SOFA score 7.5 ± 4.6 7.8 ± 4.6 7.2 ± 4.5 0.32
Recent hospitalization or home care, number (percentage) 36 (15.7) 20 (17.1) 16 (14.3) 0.31
Reasons for admission, number (percentage)     
   Acute respiratory failure 47 (20.5) 28 (23.9) 19 (16.9) 0.03
   Coma 53 (23.1) 15 (12.8) 38 (33.9) <0.001
   Septic shock 82 (35.8) 52 (44.4) 30 (26.8) <0.001
   Miscellaneous 47 (20.5) 22 (18.8) 25 (22.3) 0.29
Previous antiotherapy within 24 hours, number (percentage) 50 (21.8) 32 (27.3) 18 (16.1) <0.001
Mechanical ventilation, number (percentage) 168 (73.4) 86 (73.5) 82 (73.2) 0.73
Vasopressors, number (percentage) 111 (48.4) 68 (58.1) 43 (38.4) <0.001
Body temperature, °C 38.3 ± 1.9 39.7 ± 1.7 36.9 ± 1.9 <0.001
Leucocytes count, g/L 15.7 ± 12.2 17.1 ± 14.6 14.4 ± 8.9 0.09
Procalcitonin, ng/mL 18.9 ± 46.0 13.7 ± 28.9 23.8 ± 58.2 0.09
Suspicion of community-acquired infection, number (percentage) 166 (72.5) 90 (77.9) 76 (67.8) 0.02
Suspected infection site, number (percentage)     
   Lung 157 (68.5) 76 (64.9) 81 (72.3) 0.06
   Urinary tract 18 (7.9) 12 (10.2) 6 (5.3) 0.01
   Abdomen 24 (10.5) 14 (11.9) 10 (8.9) 0.20
   Soft and skin tissues 11 (4.8) 5 (4.2) 6 (5.3) 0.47
   Other sites 19 (8.3) 10 (8.6) 9 (8.0) 0.60
Infection finally ruled out, number (percentage) 37 (16.2) 15 (12.8) 22 (19.6) 0.05
Infection documented, number (percentage) 122 (53.3) 70 (59.8) 52 (46.4) 0.002
MDR, number (percentage) 21 (17.2) 8 (11.4) 13 (25) <0.001
Bacteremia, number (percentage) 42 (18.3) 24 (20.5) 18 (16.1) 0.15
Empiric antibiotherapy, number (percentage)     
   Appropriate 108 (47.2) 68 (58.1) 40 (35.7) <0.001
   Not appropriate 14 (6.1) 2 (1.7) 12 (10.7) <0.001
   Unknown 107 (46.7) 47 (40.2) 60 (53.6) 0.003
Duration of mechanical ventilation 7.7 1 ± 2.1 8.3 ± 11.7 7.2 ± 12.6 0.49
Duration of catecholamine administration 4.9 ± 4.8 5.4 ± 5.8 4.2 ± 4.8 0.16
Duration of antibiotic administration 7.7 ± 8.0 7.9 ± 6.4 7.5 ± 9.4 0.70
ICU-acquired infections, number (percentage) 9 (3.9) 3 (2.5) 6 (5.3) 0.15
ICU length of stay 11.5 ± 14.4 12.9 ± 15.6 10.0 ± 12.9 0.12
Mortality, number (percentage)     
   ICU 41 (17.9) 20 (17.1) 21 (18.7) 0.50
   Hospital 60 (26.2) 30 (25.6) 30 (26.8) 0.58
  1. P values are comparisons between De-escalation and No De-escalation groups. SAPS II, Simplified Acute Physiologic Score II; ICU, intensive care unit; MDR, multidrug resistant; SOFA, Sepsis-related Organ failure Assessment.