Table 1 Characteristics according to the therapeutic strategy
Characteristics | All patients (n = 229) | De-escalation (n = 117) | No de-escalation (n = 112) | P value |
|---|---|---|---|---|
Age, years | 59.5 ± 17.0 | 61.2 ± 17.3 | 57.7 ± 16.7 | 0.11 |
Sex, number (percentage) | 0.04 | |||
Male | 131 (57.2) | 62 (53) | 69 (61.6) | |
Female | 98 (42.8) | 55 (47) | 43 (38.4) | |
McCabe score | 1.1 ± 0.8 | 1.1 ± 0.8 | 1.1 ± 0.8 | 0.78 |
History of immunosuppression, number (percentage) | 22 (9.6) | 11 (9.4) | 11 (9.8) | 0.62 |
SAPS II | 51 ± 19 | 51 ± 19 | 50 ± 18 | 0.77 |
SOFA score | 7.5 ± 4.6 | 7.8 ± 4.6 | 7.2 ± 4.5 | 0.32 |
Recent hospitalization or home care, number (percentage) | 36 (15.7) | 20 (17.1) | 16 (14.3) | 0.31 |
Reasons for admission, number (percentage) | ||||
Acute respiratory failure | 47 (20.5) | 28 (23.9) | 19 (16.9) | 0.03 |
Coma | 53 (23.1) | 15 (12.8) | 38 (33.9) | <0.001 |
Septic shock | 82 (35.8) | 52 (44.4) | 30 (26.8) | <0.001 |
Miscellaneous | 47 (20.5) | 22 (18.8) | 25 (22.3) | 0.29 |
Previous antiotherapy within 24 hours, number (percentage) | 50 (21.8) | 32 (27.3) | 18 (16.1) | <0.001 |
Mechanical ventilation, number (percentage) | 168 (73.4) | 86 (73.5) | 82 (73.2) | 0.73 |
Vasopressors, number (percentage) | 111 (48.4) | 68 (58.1) | 43 (38.4) | <0.001 |
Body temperature, °C | 38.3 ± 1.9 | 39.7 ± 1.7 | 36.9 ± 1.9 | <0.001 |
Leucocytes count, g/L | 15.7 ± 12.2 | 17.1 ± 14.6 | 14.4 ± 8.9 | 0.09 |
Procalcitonin, ng/mL | 18.9 ± 46.0 | 13.7 ± 28.9 | 23.8 ± 58.2 | 0.09 |
Suspicion of community-acquired infection, number (percentage) | 166 (72.5) | 90 (77.9) | 76 (67.8) | 0.02 |
Suspected infection site, number (percentage) | ||||
Lung | 157 (68.5) | 76 (64.9) | 81 (72.3) | 0.06 |
Urinary tract | 18 (7.9) | 12 (10.2) | 6 (5.3) | 0.01 |
Abdomen | 24 (10.5) | 14 (11.9) | 10 (8.9) | 0.20 |
Soft and skin tissues | 11 (4.8) | 5 (4.2) | 6 (5.3) | 0.47 |
Other sites | 19 (8.3) | 10 (8.6) | 9 (8.0) | 0.60 |
Infection finally ruled out, number (percentage) | 37 (16.2) | 15 (12.8) | 22 (19.6) | 0.05 |
Infection documented, number (percentage) | 122 (53.3) | 70 (59.8) | 52 (46.4) | 0.002 |
MDR, number (percentage) | 21 (17.2) | 8 (11.4) | 13 (25) | <0.001 |
Bacteremia, number (percentage) | 42 (18.3) | 24 (20.5) | 18 (16.1) | 0.15 |
Empiric antibiotherapy, number (percentage) | ||||
Appropriate | 108 (47.2) | 68 (58.1) | 40 (35.7) | <0.001 |
Not appropriate | 14 (6.1) | 2 (1.7) | 12 (10.7) | <0.001 |
Unknown | 107 (46.7) | 47 (40.2) | 60 (53.6) | 0.003 |
Duration of mechanical ventilation | 7.7 1 ± 2.1 | 8.3 ± 11.7 | 7.2 ± 12.6 | 0.49 |
Duration of catecholamine administration | 4.9 ± 4.8 | 5.4 ± 5.8 | 4.2 ± 4.8 | 0.16 |
Duration of antibiotic administration | 7.7 ± 8.0 | 7.9 ± 6.4 | 7.5 ± 9.4 | 0.70 |
ICU-acquired infections, number (percentage) | 9 (3.9) | 3 (2.5) | 6 (5.3) | 0.15 |
ICU length of stay | 11.5 ± 14.4 | 12.9 ± 15.6 | 10.0 ± 12.9 | 0.12 |
Mortality, number (percentage) | ||||
ICU | 41 (17.9) | 20 (17.1) | 21 (18.7) | 0.50 |
Hospital | 60 (26.2) | 30 (25.6) | 30 (26.8) | 0.58 |