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Table 3 Shunt fraction, peripheral perfusion indices, and hemodynamics

From: High-frequency oscillation and tracheal gas insufflation in patients with severe acute respiratory distress syndrome and traumatic brain injury: an interventional physiological study

Ventilatory strategy Shunt fraction ScvO2 (%) Heart rate (beats/min) MAP (mm Hg)
Pre HFO-TGI CMV 0.49 ± 0.09 70.1 ± 6.2 95 ± 24 92 ± 12
HFO-TGI (4 hours) 0.31 ± 0.09* 74.0 ± 3.9 *,§ 92 ± 23 94 ± 13
HFO-TGI (8 hours) 0.29 ± 0.06* 74.6 ± 4.1 *,§ 92 ± 23 93 ± 14
HFO-TGI (12 hours) 0.29 ± 0.06* 75.0 ± 4.1 *,§ 92 ± 22 90 ± 15
Post HFO-TGI CMV 0.33 ± 0.14 70.5 ± 6.2 92 ± 22 90 ± 14
Ventilatory strategy Cardiac Index (L/min/m 2 BSA) DO 2 Index
(ml/min/m 2 BSA)
Arterial blood lactate (mM) CVP (mm Hg)
Pre HFO-TGI CMV 4.8 ± 1.3 510 ± 119 1.72 ± 0.70 12 ± 3.4
HFO-TGI (4 hours) 4.7 ± 1.1 541 ± 119 § 1.82 ± 0.68 12 ± 3.0
HFO-TGI (8 hours) 4.8 ± 1.1 553 ± 114 *,§ 1.85 ± 0.68 12 ± 2.9
HFO-TGI (12 hours) 4.7 ± 1.2 551 ± 119 *,§ 1.82 ± 0.69 12 ± 2.8
Post HFO-TGI CMV 4.5 ± 1.1 513 ± 106 1.81 ± 0.74 11.5 ± 3.3
  1. Values are mean ± SD. CMV, conventional mechanical ventilation; HFO, high-frequency oscillation; TGI, tracheal gas insufflation; pre-HFO-TGI CMV, corresponds to either the baseline CMV period of study day 1, or the 60-minute period that followed the 11-hour period of post-HFO-TGI CMV of the preceding study day (see also Figure 1 and corresponding legend); ScvO2, central venous O2 saturation; MAP, mean arterial pressure; BSA, body surface area; DO2, peripheral O2 delivery; CVP, central venous pressure.
  2. * P < 0.01 versus pre-HFO-TGI CMV
  3. § P < 0.05 versus post-HFO-TGI CMV