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Table 2 Ventilatory parameters of HFO-TGI sessions, oxygenation index, and respiratory mechanics.

From: High-frequency oscillation and tracheal gas insufflation in patients with severe acute respiratory distress syndrome and traumatic brain injury: an interventional physiological study

Ventilatory technique

mPaw (cm H2O)

Frequency (Hz)

ΔP (cm H2O)

TGI flow (L/min)

Oxygenation Index

Pplateau (cm H2O)

Cst (ml/cm H2O)

Pre HFO-TGI CMV

20.5 ± 3.1

NA

NA

NA

26.0 ± 8.5

30.4 ± 4.5

37.8 ± 9.2

HFO-TGI (4 hours)

31.6 ± 3.9

3.5 ± 0.4

80.9 ± 7.3

3.5 ± 0.4

20.6 ± 10.5*

NA

NA

HFO-TGI (8 hours)

30.9 ± 4.3

3.6 ± 0.6

80.4 ± 8.5

3.6 ± 0.8

17.5 ± 7.8*

NA

NA

HFO-TGI (12 hours)

30.2 ± 5.0

3.7 ± 0.9

80.1 ± 8.6

3.7 ± 0.9

15.3 ± 5.9*,§

NA

NA

Post HFO-TGI CMV

19.5 ± 3.0

NA

NA

NA

15.3 ± 5.9*,§

28.2 ± 4.6*

45.3 ± 13.1*

  1. Values are mean ± SD. CMV, conventional mechanical ventilation; HFO, high-frequency oscillation; TGI tracheal gas insufflation; pre-HFO-TGI CMV, corresponds to either the baseline CMV period of study day 1 or the 60-minute period that followed the 11-hour period of post-HFO-TGI CMV of the preceding study day (see also Figure 1 and corresponding legend); mPaw, mean airway pressure, ΔP, oscillatory pressure amplitude; Pplateau, end-inspiratory plateau airway pressure; Cst, static respiratory system compliance; NA, not applicable.
  2. *P < 0.01 versus pre-HFO-TGI CMV.
  3. § P < 0.01 versus HFO-TGI at 4 hours.