Ventilatory technique | mPaw (cm H2O) | Frequency (Hz) | ΔP (cm H2O) | TGI flow (L/min) | Oxygenation Index | Pplateau (cm H2O) | Cst (ml/cm H2O) |
---|
Pre HFO-TGI CMV
| 20.5 ± 3.1 | NA | NA | NA | 26.0 ± 8.5 | 30.4 ± 4.5 | 37.8 ± 9.2 |
HFO-TGI (4 hours)
| 31.6 ± 3.9 | 3.5 ± 0.4 | 80.9 ± 7.3 | 3.5 ± 0.4 | 20.6 ± 10.5* | NA | NA |
HFO-TGI (8 hours)
| 30.9 ± 4.3 | 3.6 ± 0.6 | 80.4 ± 8.5 | 3.6 ± 0.8 | 17.5 ± 7.8* | NA | NA |
HFO-TGI (12 hours)
| 30.2 ± 5.0 | 3.7 ± 0.9 | 80.1 ± 8.6 | 3.7 ± 0.9 | 15.3 ± 5.9*,§ | NA | NA |
Post HFO-TGI CMV
| 19.5 ± 3.0 | NA | NA | NA | 15.3 ± 5.9*,§ | 28.2 ± 4.6* | 45.3 ± 13.1* |
- Values are mean ± SD. CMV, conventional mechanical ventilation; HFO, high-frequency oscillation; TGI tracheal gas insufflation; pre-HFO-TGI CMV, corresponds to either the baseline CMV period of study day 1 or the 60-minute period that followed the 11-hour period of post-HFO-TGI CMV of the preceding study day (see also Figure 1 and corresponding legend); mPaw, mean airway pressure, ΔP, oscillatory pressure amplitude; Pplateau, end-inspiratory plateau airway pressure; Cst, static respiratory system compliance; NA, not applicable.
- *P < 0.01 versus pre-HFO-TGI CMV.
- § P < 0.01 versus HFO-TGI at 4 hours.