Relationship between extravascular lung water and severity categories of acute respiratory distress syndrome by the Berlin definition

Table 1 Characteristics of patients with ARDS based on the Berlin definition on the day of enrollment.

	mild ARDS (n= 47)	moderate ARDS (n= 82)	severe ARDS (n= 66)
Age, years	68 (59-78)	68 (59-82)	67 (53-78)
Gender (male), % (n)	70.2% (n = 33)	63.4% (n = 52)	66.7% (n = 44)
APACHE II score, points	19 (13-25)	25 (20-28)*	25 (18-30)*
SOFA score, points	9 (6-12)	11 (9-13)*	11 (10-14)*
SIRS criteria	2.0 (1.0-3.0)	2.0 (1.8-3.0)	3.0 (2.0-3.0)**
FIO₂	0.5 (0.4-0.6)	0.6 (0.5-0.8)*	1.0 (0.8-1.0)*#
PEEP, cmH₂O	8 (5-10)	10 (6-12)	10 (6-12)
PaO₂/FIO₂ ratio, mm Hg	247 (217-280)	148 (122-173)*	76 (60-90)*#
GEDI, mL/m²	780 (662-975)	814 (711-925)	730 (620-952)
EVLWi, mL/kg	16.1 (12.2-18.1)	17.2 (12.9-22.9)	19.1 (14.4-22.9)**
PVPI	2.7 (2.2-3.2)	3.0 (2.4-3.6)	3.2 (2.6-4.1)*##
Ventilator-free days within 28 days	18 (0-20)	9 (0-19)	4 (0-19)
28-day mortality, % (n)	23.4% (n = 11)	43.9% (n = 36)**	42.4% (n = 28)**

*P <0.01 vs. mild ARDS; **P <0.05 vs. mild ARDS; #P <0.01 vs. moderate ARDS; ##P <0.05 vs. moderate ARDS. ARDS, acute respiratory distress syndrome; APACHE, acute physiology and chronic health evaluation; SOFA, sequential organ failure assessment; SIRS, systemic inflammatory response syndrome; PEEP, positive end-expiratory pressure; GEDI, global end-diastolic blood volume index; EVLWi, extravascular lung water index; PVPI, pulmonary vascular permeability index.

ISSN: 1364-8535