Figure 6From: The angiotensin II AT1 receptor-associated protein Arap1 is involved in sepsis-induced hypotensionIsolated perfused kidney ( A ) Perfusate flow at constant perfusion pressure of 100 mmHg in isolated perfused kidneys from angiotensin receptor-associated protein (Arap)1-/- and wildtype mice ( n = 5). After pre-relaxation with isoproterenol (10 nM), angiotensin II was added to the perfusate to a final concentration of 10, 30, 100, 300 and 100 pM. For each concentration, three values were determined over a period of three minutes. (B) Renin secretion from isolated kidneys perfused according to the same protocol (n = 5).Back to article page