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Table 2 Hemodynamics and abdominal pressures at baseline and at 150 and 300 minutes (median and range).

From: Mechanical ventilation worsens abdominal edema and inflammation in porcine endotoxemia

CO

SB Healthy

    

L/min

PEEP 5 Healthy

3.8; 2.2-4.8

3.7; 2.4-4.4

 

3.7; 2.7-5.1

    

CPAP 5 LPS

2.7; 1.9-3.0

 

PEEP 5 LPS

2.6; 1.8-3.9

2.5; 1.7-5.3

PEEP 5 LPS

2.1; 1.8-2.93

    

PEEP 15 LPS

1.9; 1.5-2.74

HR

SB Healthy

109.5; 95-123

97.5; 81-105

 

97.5; 89-103

bpm

PEEP 5 Healthy

107.0; 78-125

109.0; 76-132

 

107; 72-132

    

CPAP 5 LPS

107.0; 93-117

 

PEEP 5 LPS

88.2; 63-120

120.6; 87-1462

PEEP 5 LPS

105; 86-117

    

PEEP 15 LPS

107.5; 95-127

MAP

SB Healthy

82.5; 59-92

67.5; 60-71

 

68.5; 58-70

mm Hg

PEEP 5 Healthy

72.5; 59-112

77.0; 56-103

 

83.0; 56-1111

    

CPAP 5 LPS

88.5; 76-90

 

PEEP 5 LPS

80.0; 57-115

74.2; 58-104

PEEP 5 LPS

81.0; 65-94

    

PEEP 15 LPS

69.0; 59-78

CVP

SB Healthy

    

mm Hg

PEEP 5 Healthy

8.5; 6-9

9; 5-10

 

8.5; 5-9

    

CPAP 5 LPS

6.5; 5-9

 

PEEP 5 LPS

7.5; 5-9

7.2; 4-11

PEEP 5 LPS

9.0; 3-11

    

PEEP 15 LPS

9.5; 9-134

MPAP

SB Healthy

    

mm Hg

PEEP 5 Healthy

18.0; 17-24

17.5; 15-26

 

17.0; 16-25

    

CPAP 5 LPS

34.5; 29-38

 

PEEP 5 LPS

16.3; 14-21

37.1; 25-482

PEEP 5 LPS

35.5; 25-45

    

PEEP 15 LPS

33.5; 31-40

APP

SB Healthy

    

mm Hg

PEEP 5 Healthy

60.8; 44.5-100

63; 42-86.5

 

70.3; 43.5-96

    

CPAP 5 LPS

68.5; 62-773

 

PEEP 5 LPS

67.9; 37.5-69.5

55.7; 31-62

PEEP 5 LPS

63.8; 43-81

    

PEEP 15 LPS

43.5; 31.6-65.0*

IAP

SB Healthy

    

mm Hg

PEEP 5 Healthy

14.0; 5.5-18

13.5; 8-20

 

13.3; 8.5-21

    

CPAP 5 LPS

17.5; 12-23.4

 

PEEP 5 LPS

11.7; 5-25

19.0; 11-292

PEEP 5 LPS

16.0; 10-22

    

PEEP 15 LPS

22.5; 13-31.5

  1. Note that the pigs given endotoxin (LPS) were all ventilated with PEEP 5 for the first 150 minutes (2.5 hours) and then either maintained on MV + PEEP 5 or switched to MV + PEEP 15 or SB + CPAP 5 for the next 2.5 hours (until 300 minutes); n = 6 in all groups. Significances (P < 0.05) after correction for multiple comparisons (Bonferroni):
  2. Comparison with:
  3. 1: SB Healthy
  4. 2: Baseline
  5. 3: 150 minutes
  6. 4: CPAP 5 LPS
  7. 5: PEEP 5 LPS
  8. *Difference of borderline significance between MV + PEEP 15 and CPAP 5 (0.05 <P < 0.10; correction for multiple comparisons).