One size does not fit all in severe infection: obesity alters outcome, susceptibility, treatment, and inflammatory response

Table 4 Fluid administration during the first four days after septic shock

	Amount of fluid, mL				Amount of fluid per body weight, mL/kg
	BMI <25 (n = 276)	BMI 25 to <30 (n = 209	BMI ≥30 (n = 245)	P value	BMI <25 (n = 276)	BMI 25 to <30 (n = 209)	BMI ≥30 (n = 245)	P value
Predicted body weight^a, kg	67 ± 2.1	64 ± 0.7	61 ± 1.0	0.003^b	-	-	-
Day 1
Intake	11,000 ± 310	10,500 ± 360	10,500 ± 310	0.27	180 ± 5	130 ± 5	100 ± 3	<0.0001^b
Output	4,100 ± 200	3,900 ± 240	3,900 ± 190	0.7	60 ± 3	50 ± 3	40 ± 2	<0.0001^b
Net accumulated balance	7,000 ± 330	6,600 ± 360	6,700 ± 330	0.43	110 ± 5	84 ± 5	70 ± 3	<0.0001^b
Day 2
Intake	16,000 ± 420	15,200 ± 500	15,400 ± 420	0.28	250 ± 7	190 ± 6	150 ± 5	<0.0001^b
Output	6,500 ± 270	6,400 ± 320	6,400 ± 290	0.95	100 ± 5	80 ± 4	60 ± 3	<0.0001^b
Net accumulated balance	9,500 ± 430	8,800 ± 490	9,000 ± 460	0.28	150 ± 7	110 ± 6	90 ± 5	<0.0001^b
Day 3
Intake	19,900 ± 520	19,000 ± 600	19,400 ± 510	0.37	320 ± 9	240 ± 8	190 ± 5	<0.0001^b
Output	9,100 ± 360	8,900 ± 410	9,300 ± 410	0.95	140 ± 6	110 ± 5	90 ± 4	<0.0001^b
Net accumulated balance	10,800 ± 490	10,200 ± 580	10,200 ± 540	0.31	170 ± 8	130 ± 7	100 ± 5	<0.0001^b
Day 4
Intake	23,600 ± 590	23,000 ± 710	23,300 ± 590	0.41	380 ± 10	290 ± 9	230 ± 7	<0.0001^b
Output	12,000 ± 430	12,300 ± 530	12,600 ± 530	0.9	190 ± 7	160 ± 7	120 ± 6	<0.0001^b
Net accumulated balance	11,700 ± 540	10,700 ± 660	10,700 ± 600	0.17	190 ± 9	140 ± 8	110 ± 6	<0.0001^b

Data are presented as mean ± standard error of the mean. P values were calculated for statistical difference between three patient groups with the use of Kruskal-Wallis test. ^aPredicted body weight (male: 50 + 0.91 (centimeters of height: 152.4), female: 45.5 + 0.91 (centimeters of height: 152.4)). ^bP <0.05. BMI, body mass index.

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