Diaphragm weakness in mechanically ventilated critically ill patients

Supinski, Gerald S; Ann Callahan, Leigh

doi:10.1186/cc12792

Critical Care

Table 2 Classification of subjects according to presence/absence of active infection at time of PdiTw measurements^a

From: Diaphragm weakness in mechanically ventilated critically ill patients

Subject number	Infected	Site	Organism(s) isolated from site(s)	Diagnosis of infection by attending physician	Antibiotic therapy^b	Pulmonary infiltrates
1	No			No	No	No
2	Yes	Liver abscess	Staphylococcus sp., Fusobacterium necrophorum	Yes	Yes	Yes
3	No			No	No	No
4	Yes	PAL	Streptococcus pneumonia	Yes	Yes	Yes
5	No			No	No	No
6	Yes	Blood	Gram-positive bacteria^c	Yes	Yes	Yes
7	Yes	PAL	Pseudomonas aeruginosa	Yes	Yes	Yes
8	Yes	Blood	Staphylococcus species	Yes	Yes	Yes
9	No			No	No	Yes^d
10	Yes	PAL	Pseudomonas aeruginosa	Yes	Yes	Yes
11	No			No	No	No
12	Yes	Sinuses	Bacteroides capillosus, Fusobacterium sp., β-strep. Gp C	Yes	Yes	Yes
		Nasopharyngeal swab	Influenza A
13	No			No	No	No
14	Yes	Jejunal drain	VRE, Pseudomonas aeruginosa	Yes	Yes	Yes
15	Yes	Blood	Staphylococcus aureus	Yes	Yes	No
16	No			No	No	No
17	Yes	PAL	Staphylococcus species	Yes	Yes	Yes
		Blood	Staphylococcus species
19	Yes	PAL	Klebsiella pneumonia	Yes	Yes	Yes
20	Yes	Blood	Staphylococcus aureus	Yes	Yes	No
21	Yes	Neck abscess	Streptococcus sp.	Yes	Yes	No
22	Yes	Sputum	Hemophilus parainfluenza	Yes	Yes	Yes
23	Yes	Stage IV decubitus	Pseudomonas aeruginosa, Proteus mirabilis	Yes	Yes	No
		Urine	Pseudomonas aeruginosa
24	No			No	No	No
25	No			No	No	No
26	No			No	No	No
27	Yes	Subphrenic abscess	Candida glabrata	Yes	Yes	Yes
28	No			No	No	No
29	Yes	BAL	Escherichia coli, Klebsiella pneumoniae	Yes	Yes	Yes
30	No			No	No	No
31	No			No	No	Yes^d
32	Yes	Blood	Enterococcus faecalis	Yes	Yes	No
33	Yes	PAL	Staphylococcus aureus	Yes	Yes	Yes
34	Yes	Blood	Gram-positive cocci^c	Yes	Yes	Yes
35	Yes	ET aspirate	Acinetobacter calcoaceticus, Enterobacter cloacae	Yes	Yes	Yes
		Blood	Candida
36	Yes	PAL	Achromobacter xyloxosidans	Yes	Yes	Yes
		Central venous catheter	Pseudomonas aeruginosa
37	Yes	PAL	Pseudomonas aeruginosa	Yes	Yes	Yes
38	Yes	Liver abscess	Escherichia coli	Yes	Yes	Yes
39	Yes	PAL	Staphylococcus sp., Enterobacter aerogenes, Escherichia coli	Yes	Yes	Yes
40	Yes	PAL	MRSA	Yes	Yes	Yes
		Blood	MRSA
41	Yes	Nasopharyngeal swab	Influenza B	Yes	Yes	Yes
42	Yes	Blood	MRSA	Yes	Yes	Yes
		Leg abscess	MRSA
		Osteomyelitis	MRSA
44	No			No	No	Yes^d
45	No			No	No	No
46	Yes	Sputum	MRSA	Yes	Yes	Yes
47	Yes	PAL	Streptococcus pneumonia	Yes	Yes	Yes
49	No			No	No	No
50	Yes	Pleural fluid	Acinetobacter baumannii, VRE	Yes	Yes	Yes
		Pleural tissue	Acinetobacter baumannii, VRE
51	Yes	Blood	Bacillus circulans	Yes	Yes	Yes
52	Yes	Blood	VRE	Yes	Yes	Yes
53	Yes	PAL	Pseudomonas aeruginosa	Yes	Yes	Yes
		Nasopharyngeal swab	H1N1
54	Yes	Blood	VRE	Yes	Yes	Yes
		Tracheal aspirate	Stenotrophomonas maltophilia
55	Yes	PAL	MRSA	Yes	Yes	Yes
56	Yes	Blood	MRSA, Pseudomonas aeruginosa, VRE	Yes	Yes	Yes
		Sputum	Pseudomonas aeruginosa
57	Yes	BAL	Samples lost^e	Yes	Yes	Yes
58	Yes	Tracheal aspirate	Hemophilus influenza	Yes	Yes	Yes
59	Yes	Blood	Staphylococcus species	Yes	Yes	No
60	Yes	Urine	Enterobacter cloacae	Yes	Yes	Yes
		PAL	Streptococcus sp.

^aData not included for Subjects 18, 43, and 48 because transdiaphragmatic twitch pressure (PdiTw) measurements were not obtained due to anatomic constraints. ^bPatient on antibiotic therapy at the time of PdiTw measurement. ^cOrganism not speciated - subject treated with antibiotics prior to transfer.^dPatient with pulmonary infiltrates but without evidence of infection (Subject 9 with nonpulmonary acute lung injury, Subject 31 with pulmonary fibrosis, Subject 44 with acute respiratory distress syndrome). ^eBronchoscopy performed with purulent exudates noted; specimens lost in transit to laboratory. BAL, bronchoalveolar lavage; MRSA, methicillin-resistant Staphylococcus aureus; PAL, protected alveolar lavage; VRE, Enterococcus faecium (vancomycin-resistant).

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