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Table 5 ECG interpretation at each time point in patients randomized to vasopressin or norepinephrine (N = 121)

From: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine

 

Vasopressin (n= 65)

Norepinephrine (n= 56)

P value

Variable, n (%)

Baseline ( n = 61)

6 hours ( n = 43)

Day 2 ( n = 44)

Day 4 ( n = 39)

Baseline ( n = 54)

6 hours ( n = 40)

Day 2 ( n = 48)

Day 4 ( n = 35)

 

Normala

19 (31)

15 (35)

14 (32)

19 (49)

10 (19)

12 (30)

14 (29)

8 (23)

0.267

Ischemiaa

9 (15)

6 (14)

8 (18)

3 (8)

9 (17)

2 (5)

3 (6)

3 (9)

0.099

Atrial fib/ flutter/PSVT

6 (10)

10 (23)

7 (16)

4 (10)

15 (28)

13 (33)

14 (29)

8 (23)

0.427

Bundle branch block

6 (10)

4 (10)

6 (14)

4 (10)

7 (13)

4 (10)

7 (15)

7 (20)

0.359

ST elevation

6 (10)

4 (10)

3 (7)

2 (5)

4 (7)

3 (8)

3 (6)

1 (3)

0.869

ST depression

5 (9)

4 (10)

6 (14)

1 (3)

8 (15)

2 (5)

2 (4)

3 (9)

0.317

T inversion

10 (16)

10 (23)

8 (18)

6 (15)

12 (22)

8 (20)

11 (23)

8 (23)

0.530

Q wave

11 (18)

3 (7)

6 (14)

7 (18)

12 (22)

8 (20)

10 (21)

9 (26)

0.039

Ventricular rhythm

0 (0)

0 (0)

0 (0)

0 (0)

1 (2)

0 (0)

1 (2)

0 (0)

-b

Arrhythmiac

6 (10)

10 (23)

7 (16)

4 (10)

16 (30)

13 (33)

15 (31)

8 (23)

0.339

  1. ECG findings at each time point for patients randomized to vasopressin and norepinephrine. Values are expressed as n (%). P value is based on logistic mixed-effects model and is for the null hypothesis of no difference in ECG interpretation between the treatment groups at 6 hours, day 2, and day 4, adjusted for baseline interpretation. ECG interpretation results are based only on the data of Reader 2, blinded to randomization group and troponin level. aThe reader was asked for an overall assessment of whether the ECG was normal or abnormal, and whether, in his opinion, the ECG changes represented ischemia. bEvent rate is too low for P-value calculation. cArrhythmia includes atrial fibrillation, atrial flutter, paroxysmal supraventricular tachyarrhythmia, and ventricular rhythm.
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