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Table 2 Characteristics of patients in the troponin substudy

From: Cardiac ischemia in patients with septic shock randomized to vasopressin or norepinephrine

Variable Vasopressin
(n= 65)
Norepinephrine
(n= 56)
Age, years 62.9 (51.2, 73.6) 65.5 (50.8, 76.1)
Male sex, n (%) 43 (66) 42 (75)
Surgical patient, n (%) 25 (39) 25 (45)
APACHE II 28.1 (8.0) 29.2 (7.3)
Preexisting conditions, n (%)
    Ischemic heart disease
    Chronic obstructive pulmonary disease
    Chronic renal failure
    Diabetes
    Liver disease
    Cancer
    Solid-organ transplant
    Corticosteroid use
    Recent trauma
9 (14)
6 (9)
8 (12)
13 (20)
12 (18)
17 (26)
4 (6)
9 (14)
1 (2)
8 (14)
11 (20)
9 (16)
13 (23)
9 (16)
13 (23)
5 (9)
8 (14)
3 (5)
New organ failure at randomization, n (%)
    Cardiovascular
    Respiratory
    Renal
    Hematology/coagulation
    Neurologic
65 (100)
58 (89)
43 (66)
20 (31)
21 (32)
56 (100)
50 (89)
41 (73)
13 (23)
18 (32)
Number of organ dysfunctions at randomization 3.0 (2.0, 3.0) 3.0 (2.0, 4.0)
Source of infection, n (%)
    Lung
    Abdomen
    Othera
28 (43)
19 (29)
18 (28)
28 (50)
16 (29)
12 (21)
Hemodynamic variables at randomization
    Systolic blood pressure (mm Hg)
    Mean arterial pressure (mm Hg)
    Arterial pH
    Serum lactate (mM)
110.0 (98.0, 118.0)
72.0 (67.0, 77.0)
7.34 (7.3, 7.4)
2.3 (1.5, 3.6)
105.0 (95.0, 114.0)
70.0 (65.0, 75.0)
7.36 (7.3, 7.4)
2.2 (1.6, 4.1)
Vasoactive drug dosages at randomization
    Norepinephrine (μg/min)
    Epinephrine (μg/min)
    Dopamine (μg/kg/min)
    Dobutamine (μg/kg/min)
    Phenylephrine (μg/min)
14.9 (9.1, 26.6)
30.0 (30.0, 30.0)
3.1 (3.0, 6.0)
6.3 (2.5, 12.5)
66.5 (31.1, 133.2)
18.1 (10.6, 30.0)
25.2 (8.4, 42.0)
8.2 (4.0, 17.0)
7.5 (2.5, 10.0)
104.7 (43.0, 134.5)
Days alive free of mechanical ventilation (first 28 days) 0.5 (0.0, 17.0) 1.0 (0.0, 16.0)
ICU stay,b days 11.5 (6.0, 26.0) 13.0 (6.0, 12.0)
Hospital stay,b days 26.5 (10.5, 74.0) 37.5 (18.5, 89.5)
28-day mortality,c n (%) 27 (42) 24 (43)
90-day mortality,c n (%) 31 (48) 32 (57)
  1. Baseline characteristics and outcomes of patients randomized to vasopressin and norepinephrine. Continuous variables are presented as median and interquartile range. APACHE II is expressed as mean and standard deviation. APACHE II, Acute Physiology and Chronic Health Evaluation II; ICU, intensive care unit. aOther sites of infection included blood, skin, central nervous system, bones and joints, cardiac system, and reproductive organs. bCensored at day 90 if patient did not die or was not discharged prior to day 90. ICU and hospital stay are from time of admission to the ICU. cOutcome of one patient in the vasopressin group was unknown and excluded from the calculations.