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Table 2 Association of 72-hour PCT kinetics and ICU and total in-hospital mortality

From: Procalcitonin decrease over 72 hours in US critical care units predicts fatal outcome in sepsis patients

 

Derivation cohort

(number = 154)

Validation cohort

(number = 102)

Discrimination: AUC (95%CI)

ICU mortality

0.70 (0.61, 0.79)

0.71 (0.57, 0.84)

In-hospital mortality

0.70 (0.61, 0.78)

0.67 (0.54, 0.79)

Adjusted regression analysesa OR (95%CI), P value

ICU mortality

  

Per 10% PCT decrease

1.3 (1.1, 1.5), 0.001

1.3 (1.1, 1.6), 0.01

In-hospital mortality

  

Per 10% PCT decrease

1.3 (1.1, 1.4), 0.001

1.2 (1.04, 1.4), 0.012

  1. aAdjusted for severity using the clinical risk score routinely obtained at ICU admission (APACHE IV score in the derivation cohort, SAPS II score in the validation cohort). AUC, area under the receiver operating characteristic curve; CI, confidence interval; ICU, intensive care unit; OR, odds ratio; PCT, procalcitonin.
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Critical Care

ISSN: 1364-8535