Table 1 Characteristics of the two study cohorts
Variable | Derivation cohort (number = 154) | Validation cohort (number = 102) | P |
|---|---|---|---|
Demographics | Â | Â | Â |
Age (years), mean ± SD | 65.8 ± 16.2 | 65.8 ±17.0 | 0.97 |
Female gender, % (number) | 55.2% (85) | 43.1% (44) | 0.06 |
Race, % (number) | Â | Â | <0.01 |
White | 89.6%(138) | 48.0% (49) | Â |
African-American | 6.5% (10) | 13.7% (14) | Â |
Hispanic | 0 0% (0) | 15.7% (16) | Â |
Asian | 3.9% (6) | 12.7% (13) | Â |
Other | 0% (0) | 9.8% (10) | Â |
Primary locus for sepsis, % (number) | Â | Â | <0.01 |
Respiratory tract | 45.5% (70) | 39.2% (40) | Â |
Intra-abdominal | 21.4% (33) | 13.7% (14) | Â |
Skin | 0 (0) | 2.0% (2) | Â |
Urinary tract | 16.9% (26) | 3.9% (4) | Â |
Bacteremia without organ specified | 13.0% (20) | 13.7% (14) | Â |
Other infections including nervous system, prosthesis, heart, abscesses | 3.3% (5) | 27.5% (28) | Â |
Type of admission, % (number) | Â | Â | 0.68 |
Medical | 83.1% (128) | 84.3% (86) | Â |
Surgical | 17.6% (26) | 15.7% (16) | Â |
Admission risk score, mean ± SD |  |  |  |
APACHE IV | 81.8 ± 25.9 | NA |  |
SAPS II | NA | 45.3 ± 14.3 |  |
PCT concentrations (µg/L), mean ± SD |  |  | |
Admission | 32.6 ± 40.6 | 27.4 ± 44.9 | 0.34 |
After 72 ± 12 hours in ICU | 13.3 ± 21.8 | 16.1 ± 40.4 | 0.46 |
Length-of-stay, days, mean ± SD |  |  |  |
ICU | 7.7 ± 6.3 | 6.9 ± 5.1 | 0.04 |
Total hospital | 15.9 ± 10.7 | 15.4 ±10.1 | 0.66 |
Mortality, % (number), 95% CI | Â | Â | Â |
ICU | 29.2% (45) 22.0% to 36.4%] | 17.6% (18) 10.1% to 25.2% | 0.04 |
Total in-hospital | 31.8% (49) 24.4% to 39.3% | 29.4% (30) 20.4% to 38.5%) | 0.68 |