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Table 2 Prevalence of hypocalcaemia on day 4 and mortality in different patient subgroups.

From: Assessment and clinical course of hypocalcemia in critical illness

Subgroup

Day 4 iCa (mmol/L)

n(%)

P valuea

Mortality

P valueb

All patients

<1.1

210 (30)

 

46 (21.9)

 
 

>1.1

489 (70)

-

102 (20.9)

0.76

Admission iCa <0.9 mmol/L

<1.1

24 (53.3)

 

9 (37.5)

 
 

>1.1

21 (46.7)

 

4 (19)

0.15*

Admisson iCa 0.9-1.09 mmol/L

<1.1

121 (35.2)

 

25 (20.7)

 
 

>1.1

223 (64.8)

 

50 (22.4)

0.71*

Admission iCa 1.1-1.3 mmol/L

<1.1

64 (21.9)

 

12 (18.8)

 
 

>1.1

228 (78.1)

0.001

45 (19.7)

0.86*

Hypocalcemia & sepsis

<1.1

98 (38.1)

 

24 (24.5)

 
 

>1.1

159 (61.9)

 

34 (21.4)

0.56**

Hypocalcemia & no sepsis

<1.1

47 (35.6)

 

10 (21.3)

 
 

>1.1

85 (64.4)

0.63

20 (23.5)

0.77**

Admission iCa <1.1 mmol/L:

Survivors

<1.1

111 (36.9)

 

0

 
 

>1.1

190 (63.1)

 

0

 

Admission iCa <1.1 mmol/L:

Non-survivors

<1.1

34 (38.6)

 

100

 
 

>1.1

54 (61.4)

0.76

100

-

Adm iCa <1.1 & AdjCa <2.2 mmol/L (given supplementation)

<1.1

121 (39.7)

 

29 (24.0)

 
 

>1.1

184 (60.3)

 

42 (22.8)

0.82**

Adm iCa <1.1 & AdjCa >2.2 mmol/L (not given supplementation)

<1.1

24 (28.9)

 

5 (20.8)

 
 

>1.1

59 (71.1)

0.073

12 (20.3)

0.96**

  1. Mortality is reported as n (%). All P values are derived from the chi-squared test for independence between groups.
  2. aDifference in % patients with iCa >1.1 mmol/L by day 4 between subgroups.
  3. bDifference in mortality by day 4 iCa status within each subgroup.
  4. Bonferroni correction was performed where multiple subgroup analyses were carried out; *P < 0.017, **P < 0.025 required for statistically significant result.
  5. AdjCa, Adjusted calcium; iCa, Ionized calcium.