Skip to main content

Table 2 Statistical heterogeneity: PROWESS versus PROWESS-SHOCK - 28-day mortality

From: Severe sepsis: are PROWESS and PROWESS-SHOCK trials comparable? A clinical and statistical heterogeneity analysis

Patient population Trial Risk ratio (95% CI) Heterogeneity P-value Heterogeneity I-square
All PROWESS 0.80 (0.69-0.94)   
  PROWESS-SHOCK 1.09 (0.92-1.28)   
  Overall 0.93 (0.69-1.26) 0.008 85.8%
Shock Only PROWESS 0.77 (0.65-0.92)   
  PROWESS-SHOCK 1.09 (0.92-1.28)   
  Overall 0.92 (0.65-1.29) 0.005 87.4%
APACHE II ≥ 25 PROWESS 0.71 (0.59-0.85)   
  PROWESS-SHOCK 1.11 (0.90-1.37)   
  Overall 0.88 (0.57-1.37) 0.002 89.9%
Organ failure ≥ 3 PROWESS 0.77 (0.63-0.94)   
  PROWESS-SHOCK 1.04 (0.90-1.20)   
  Overall 0.90 (0.68-1.21) 0.017 82.3%
  1. CI, confidence interval.