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Table 1 Kinetic parameters.

From: Interactions between the volume effects of hydroxyethyl starch 130/0.4 and Ringer´s acetate

 

HES (n= 10)

Ringer's acetate (n= 10)

HES and Ringer's acetate* (n= 10)

Wilcoxon's matched-pair test

Vc (L) for HES

3.07 (0.52)

 

3.18 (0.56)

NS

Vc (L) for Ringer's

 

5.53 (4.25-7.31)

4.00 (3.05-4.82)

P < 0.03

k12 (10-3 min-1)

 

20 (17-50)

41 (27-99)

NS

k21 (10-3 min-1)

 

9 (3-27)

19 (10-27)

NS

k10 (10-3 min-1) HES

6.5 (2.1)

 

6.4 (3.3)

NS

k10 (10-3 min-1) Ringer's

 

7.3 (5.0-12.9)

1.7 (0.1-4.6)**

P < 0.03

T1/2 (min) HES

116 (35)

 

126 (75-150)

NS

T1/2 (min) Ringer's

 

88 (54-150)

497 (146-805)

P < 0.02

  1. Data are the mean (SD) or median (25th to 75th percentile) for the group. *The standard errors of the estimates (precision) were 4% for Vc and k12 and 16% for k21 (median); **two negative values were set to the third lowest values in the series. HES, hydroxyethyl starch; Vc, size of central body fluid space at baseline and during fluid therapy; k12, rate constant for fluid passing from vc to vp; k21, rate constant for fluid passing from vp to vc; k10, rate constant for fluid leaving the system; T1/2, half-life.
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