Susceptibility to ventilator induced lung injury is increased in senescent rats

Table 3 Survival in old and young mechanically ventilated rats

Survival	>3 hours of MV		Complete ventilation period (4 h)
_Age	young	old	young	old
_VT 8 ml/kg	100%	100%	87%	93%
_VT 16 ml/kg	100%	87%	100%	80%
_VT 24 ml/kg	93%	73%	80%	33% *

N = 15 per group;
Animals were ventilated with either low (8 ml/kg), high (16 ml/kg) or very high (24 ml/kg) tidal volume (VT). * P = 0.013 vs. old animals with same tidal volume at the same time point.

ISSN: 1364-8535