Invasive mechanical ventilation as a risk factor for acute kidney injury in the critically ill: a systematic review and meta-analysis

Table 3 Summary of the characteristics of the studies with different settings for PEEP.

		Higher PEEP	Higher PEEP	Lower PEEP	Lower PEEP
Author/year	Diagnosis	Vt (ml/kg)	PEEP (cm H2O)	Vt (ml/kg)	PEEP (cm H2O)
Amato 1998 [34]	ARDS	6	16.4 ± 0.4	12	8.7 ± 0.4
Vivino 1998 [11]	Trauma	Not reported	>6	Not reported	<6
Ranieri 2000 [36]	ARDS	7,6 ± 1.1	14.8 ± 2.7	11.1 ± 1.9	6.5 ± 1.7
Parikh 2005 [37]	ALI/ARDS	6.2 ± 0.9	9.4 ± 3.6	11.8 ± 0.8	8.6 ± 3.6
Villar 2006 [38]	ARDS	7.3 ± 0.9	14.1 ± 2.8	10.2 ± 1.2	9.0 ± 2.7
Manzano 2008 [39]	No ALI	7.79 ± 1.71	5.78 ± 1.0	7.91 ± 1.40	0.12 ± 0.7
Meade 2008 [40]	ALI/ARDS	6.8 ± 1.4	15.6 ± 3.9	6.8 ± 1.3	10.1 ± 2.9

Vt, tidal volume; PEEP, positive end-expiratory pressure; ARDS, acute respiratory distress syndrome; ALI, acute lung injury. Data presented as mean ± standard deviation.

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