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Table 3 Summary of the characteristics of the studies with different settings for PEEP.

From: Invasive mechanical ventilation as a risk factor for acute kidney injury in the critically ill: a systematic review and meta-analysis

   Higher PEEP Higher PEEP Lower PEEP Lower PEEP
Author/year Diagnosis Vt (ml/kg) PEEP (cm H2O) Vt (ml/kg) PEEP (cm H2O)
Amato 1998 [34] ARDS 6 16.4 ± 0.4 12 8.7 ± 0.4
Vivino 1998 [11] Trauma Not reported >6 Not reported <6
Ranieri 2000 [36] ARDS 7,6 ± 1.1 14.8 ± 2.7 11.1 ± 1.9 6.5 ± 1.7
Parikh 2005 [37] ALI/ARDS 6.2 ± 0.9 9.4 ± 3.6 11.8 ± 0.8 8.6 ± 3.6
Villar 2006 [38] ARDS 7.3 ± 0.9 14.1 ± 2.8 10.2 ± 1.2 9.0 ± 2.7
Manzano 2008 [39] No ALI 7.79 ± 1.71 5.78 ± 1.0 7.91 ± 1.40 0.12 ± 0.7
Meade 2008 [40] ALI/ARDS 6.8 ± 1.4 15.6 ± 3.9 6.8 ± 1.3 10.1 ± 2.9
  1. Vt, tidal volume; PEEP, positive end-expiratory pressure; ARDS, acute respiratory distress syndrome; ALI, acute lung injury. Data presented as mean ± standard deviation.