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Figure 4 | Critical Care

Figure 4

From: Anti-vascular endothelial growth factor antibody attenuates inflammation and decreases mortality in an experimental model of severe sepsis

Figure 4

Effects of differing bevacizumab treatment times on mortality in the murine models of sepsis. A, Delayed administration of Bev is protective in cecal ligation and puncture (CLP). Kaplan-Meier survival analysis following CLP in mice comparing the efficacy of pre- and post-surgical bevacizumab (Bev) treatment at various time intervals relative to the CLP control. Bev administration significantly enhanced survival relative to the CLP controls (P = 0.006 in the pre-treated group, and P = 0.033 in the 6 h post-treated group), except for mice in which Bev administration was delayed for 12 h (12 h delayed-treatment group, P = 0.062). B, Lethality from endotoxemia was diminished with delayed Bev administration, but not statistically significantly so.

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Critical Care

ISSN: 1364-8535