Characteristic | Without T allele (n = 80) | With T allele (n = 195) | P value |
---|---|---|---|
Gender (male) | 70 (87.5) | 111 (56.9) | <0.001 |
Age (years) | 62 (53 to 72) | 60 (48 to 69) | 0.12 |
Diabetes mellitus | 26 (32.5) | 60 (30.8) | 0.77 |
Myocardial infarction | 7 (8.8) | 11 (5.6) | 0.42 |
Chronic obstructive pulmonary disease | 12 (15.0) | 26 (13.3) | 0.70 |
Asthma | 2 (2.5) | 4 (2.1) | 0.99 |
Site of infection | 0.86 | ||
Respiratory | 47 (58.8) | 106 (54.4) | |
Abdominal | 23 (28.8) | 57 (29.2) | |
Neurological | 1 (1.3) | 4 (2.1) | |
Urinary | 2 (2.5) | 12 (6.2) | |
Skin | 3 (3.8) | 8 (4.1) | |
Endocarditis | 4 (5.0) | 7 (3.6) | |
Others | 0 (0) | 1 (0.5) | |
Bloodstream infection | 11 (13.8) | 31 (15.9) | 0.71 |
PaO2/FIO2 ratio | 150 (103 to 248) | 176 (107 to 262) | 0.82 |
Creatinine (mg/dl) | 1.00 (0.85 to 2.03) | 1.40 (0.80 to 2.40) | 0.02 |
Bilirubin (mg/dl) | 0.80 (0.43 to 1.45) | 0.90 (0.46 to 1.80) | 0.64 |
Leukocytes (×103/mm3) | 14.6 (10.2 to 20.0) | 15.0 (9.1 to 20.4) | 0.99 |
Lactic acid (mmol/l) | 1.80 (1.20 to 3.10) | 2.30 (1.30 to 4.60) | 0.02 |
Platelets (×103/mm3) | 227 (132 to 303) | 165 (93 to 234) | 0.007 |
INR | 1.32 (1.06 to 1.55) | 1.35 (1.14 to 1.58) | 0.46 |
aPTT (seconds) | 33 (29 to 44) | 32 (28 to 41) | 0.28 |
APACHE II score | 19 (15 to 24) | 20 (16 to 24) | 0.41 |
TIMP-1 (ng/ml) | 523 (355 to 707) | 639 (444 to 880) | 0.004 |
MMP-9 (ng/ml) | 759 (389 to 1,224) | 606 (275 to 1,022) | 0.11 |
MMP-10 (pg/ml) | 1706 (1,016 to 2,539) | 1,795 (1,237 to 3,514) | 0.12 |
TNFα (pg/ml) | 27.8 (18.1 to 47.1) | 31.8 (20.1 to 57.9) | 0.37 |
IL-10 (pg/ml) | 10.1 (5.6 to 55.4) | 14.55 (6.0 to 60.5) | 0.36 |
PAI-1 (ng/ml) | 39.9 (25.2 to 63.4) | 44.8 (24.6 to 71.5) | 0.48 |
Survivors at 30 days | 61 (76.3) | 118 (60.5) | 0.02 |