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Table 1 Patient characteristics according to the 372 C/T genetic polymorphism of tissue inhibitor of matrix metalloproteinase-1

From: The 372 T/C genetic polymorphism of TIMP-1 is associated with serum levels of TIMP-1 and survival in patients with severe sepsis

Characteristic

Without T allele (n = 80)

With T allele (n = 195)

P value

Gender (male)

70 (87.5)

111 (56.9)

<0.001

Age (years)

62 (53 to 72)

60 (48 to 69)

0.12

Diabetes mellitus

26 (32.5)

60 (30.8)

0.77

Myocardial infarction

7 (8.8)

11 (5.6)

0.42

Chronic obstructive pulmonary disease

12 (15.0)

26 (13.3)

0.70

Asthma

2 (2.5)

4 (2.1)

0.99

Site of infection

  

0.86

  Respiratory

47 (58.8)

106 (54.4)

 

  Abdominal

23 (28.8)

57 (29.2)

 

  Neurological

1 (1.3)

4 (2.1)

 

  Urinary

2 (2.5)

12 (6.2)

 

  Skin

3 (3.8)

8 (4.1)

 

  Endocarditis

4 (5.0)

7 (3.6)

 

  Others

0 (0)

1 (0.5)

 

Bloodstream infection

11 (13.8)

31 (15.9)

0.71

PaO2/FIO2 ratio

150 (103 to 248)

176 (107 to 262)

0.82

Creatinine (mg/dl)

1.00 (0.85 to 2.03)

1.40 (0.80 to 2.40)

0.02

Bilirubin (mg/dl)

0.80 (0.43 to 1.45)

0.90 (0.46 to 1.80)

0.64

Leukocytes (×103/mm3)

14.6 (10.2 to 20.0)

15.0 (9.1 to 20.4)

0.99

Lactic acid (mmol/l)

1.80 (1.20 to 3.10)

2.30 (1.30 to 4.60)

0.02

Platelets (×103/mm3)

227 (132 to 303)

165 (93 to 234)

0.007

INR

1.32 (1.06 to 1.55)

1.35 (1.14 to 1.58)

0.46

aPTT (seconds)

33 (29 to 44)

32 (28 to 41)

0.28

APACHE II score

19 (15 to 24)

20 (16 to 24)

0.41

TIMP-1 (ng/ml)

523 (355 to 707)

639 (444 to 880)

0.004

MMP-9 (ng/ml)

759 (389 to 1,224)

606 (275 to 1,022)

0.11

MMP-10 (pg/ml)

1706 (1,016 to 2,539)

1,795 (1,237 to 3,514)

0.12

TNFα (pg/ml)

27.8 (18.1 to 47.1)

31.8 (20.1 to 57.9)

0.37

IL-10 (pg/ml)

10.1 (5.6 to 55.4)

14.55 (6.0 to 60.5)

0.36

PAI-1 (ng/ml)

39.9 (25.2 to 63.4)

44.8 (24.6 to 71.5)

0.48

Survivors at 30 days

61 (76.3)

118 (60.5)

0.02

  1. Data presented as number (percentage) or median (25th to 75th percentile). APACHE, Acute Physiology and Chronic Health Evaluation; aPTT, activated partial thromboplastin time; INR, International Normalised Ratio; MMP, matrix metalloproteinase; PaO2/FIO2, pressure of arterial oxygen/fraction inspired oxygen; PAI-1, plasminogen activator inhibitor-1; TIMP, tissue inhibitor of matrix metalloproteinase.