Table 3 ROC curves comparing the discriminant power of mt-DNA, H-FBAP, n-DNA and Tn-I to predict 15-day mortality in massive PE.
Test | Cutoff | AUC (95% CI) | Sens. (95% CI) | Spec (95% CI) | PPV (%) | NPV (%) | +LR | -LR | P value |
|---|---|---|---|---|---|---|---|---|---|
mt-DNA | 3380 GE/ml | 0.89 (0.78-0.99) | 94.4 (82.0-95.6) | 68.4 (64.1-87.5) | 73.9 | 92.9 | 17.6 | 0.08 | <0.001 |
H-FBAP | 6.8 ng/ml | 0.76 (0.69-0.93) | 88.9 (78.3-93.1) | 85.7 (76.8-91.8) | 69.5 | 85.7 | 6.2 | 0.13 | <0.001 |
n-DNA | 3625 GE/ml | 0.73 (0,58-0.91) | 77.8 (64.1-85.5) | 57.9 (48.2-71.4) | 63.6 | 73.3 | 5.03 | 0.38 | <0.05 |
Tn-I | 0.020 µg/ml | 0.59 (0.41-0.79) | 66.7 (51.3-78.0) | 47.4 (35.2-60.1) | 54.5 | 60.0 | 0.75 | 0.70 | NS |