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Table 2 Exclusion criteria in patients from the Cub-Rea database with severe sepsis and septic shock.

From: Are clinical trials dealing with severe infection fitting routine practices? Insights from a large registry

Exclusion criteria

At least one criterion

One single criterion

Combination of two criteria

Combination of >2 criteria

 

40,325

26,316

10,599

3,410

Age <18 years

377 (0.6%)

217 (0.8%)

84 (0.8%)

76 (2.2%)

Age >75 years

15,871 (23%)

9,733 (37%)

4,854 (46%)

1,284 (38%)

Pregnancy

80 (0.1%)

43 (0.1%)

28 (0.3%)

9 (0.3%)

Congestive heart failure

7,457 (11%)

2,848 (11%)

3,364 (32%)

1,245 (37%)

Cancer

7,266 (11%)

2,810 (11%)

2,820 (27%)

1,636 (45%)

Severe immune suppressiona

8,930 (13%)

3,600 (14%)

2,975 (28%)

2,355 (69%)

AIDS

3,519 (5%)

2,400 (9%)

759 (7%)

360 (11%)

Neutropenia

2,949 (4%)

492 (2%)

1,270 (12%)

1,187 (35%)

Solid organ graft

2,462 (4%)

708 (3%)

946 (9%)

808 (24%)

Coagulation abnormalities

5,481 (8%)

1,567 (6%)

2,231 (22%)

1,613 (47%)

Gastrointestinal and liver disorders

5,416 (8%)

2,197 (8%)

2,003 (19%)

1,216 (36%)

Chronic renal failure requiring RTT

1,990 (3%)

660 (3%)

796 (8%)

534 (16%)

Overweight

2,027 (3%)

910 (3%)

716 (7%)

401 (12%)

Cerebrovascular stroke

1,953 (3%)

1,055 (4%)

639 (6%)

259 (8%)

Burns

160 (0.2%)

69 (0.2%)

55 (0.5%)

36 (0.1%)

  1. Results expressed as number (%). CuB-Rea, College des Utilisateurs de Bases de données en Réanimation; RTT, renal replacement therapy. aSevere immune suppression category combines patients with AIDS or neutropenia or transplant. Transplant category combines patients with bone marrow, kidney, liver, and heart or lung transplant.