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Table 2 Exclusion criteria in patients from the Cub-Rea database with severe sepsis and septic shock.

From: Are clinical trials dealing with severe infection fitting routine practices? Insights from a large registry

Exclusion criteria At least one criterion One single criterion Combination of two criteria Combination of >2 criteria
  40,325 26,316 10,599 3,410
Age <18 years 377 (0.6%) 217 (0.8%) 84 (0.8%) 76 (2.2%)
Age >75 years 15,871 (23%) 9,733 (37%) 4,854 (46%) 1,284 (38%)
Pregnancy 80 (0.1%) 43 (0.1%) 28 (0.3%) 9 (0.3%)
Congestive heart failure 7,457 (11%) 2,848 (11%) 3,364 (32%) 1,245 (37%)
Cancer 7,266 (11%) 2,810 (11%) 2,820 (27%) 1,636 (45%)
Severe immune suppressiona 8,930 (13%) 3,600 (14%) 2,975 (28%) 2,355 (69%)
AIDS 3,519 (5%) 2,400 (9%) 759 (7%) 360 (11%)
Neutropenia 2,949 (4%) 492 (2%) 1,270 (12%) 1,187 (35%)
Solid organ graft 2,462 (4%) 708 (3%) 946 (9%) 808 (24%)
Coagulation abnormalities 5,481 (8%) 1,567 (6%) 2,231 (22%) 1,613 (47%)
Gastrointestinal and liver disorders 5,416 (8%) 2,197 (8%) 2,003 (19%) 1,216 (36%)
Chronic renal failure requiring RTT 1,990 (3%) 660 (3%) 796 (8%) 534 (16%)
Overweight 2,027 (3%) 910 (3%) 716 (7%) 401 (12%)
Cerebrovascular stroke 1,953 (3%) 1,055 (4%) 639 (6%) 259 (8%)
Burns 160 (0.2%) 69 (0.2%) 55 (0.5%) 36 (0.1%)
  1. Results expressed as number (%). CuB-Rea, College des Utilisateurs de Bases de données en Réanimation; RTT, renal replacement therapy. aSevere immune suppression category combines patients with AIDS or neutropenia or transplant. Transplant category combines patients with bone marrow, kidney, liver, and heart or lung transplant.