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Table 1 Exclusion criteria from randomized controlled trials dealing with severe sepsis and septic shock

From: Are clinical trials dealing with severe infection fitting routine practices? Insights from a large registry

Exclusion criteria

Number (%) of trials (n= 96)

Vasopressors (n= 37)

Fluid loading (n= 8)

Steroids (n= 8)

Modulation of immunity (n= 28)

Modulation of coagulation (n= 11)

Miscellaneous (n= 4)

Pregnancy

46 (47%)

16 (43%)

2 (25%)

4 (50%)

15 (54%)

6 (55%)

4 (100%)

Age <18 years

39 (40%)

7 (19%)

6 (75%)

5 (63%)

13 (46%)

7 (63%)

1 (25%)

Age >75 years

4 (4%)

1 (3%)

1 (13%)

1 (13%)

1 (4%)

0

0

Congestive heart failure

34 (35%)

13 (35%)

2 (25%)

3 (38%)

12 (43%)

2 (18%)

1 (25%)

Cancer

29 (30%)

7 (19%)

2 (25%)

3 (38%)

11 (39%)

6 (55%)

2 (50%)

Gastrointestinal and liver disorder

17 (18%)

6 (16%)

2 (25%)

2 (25%)

6 (21%)

3 (27%)

1 (25%)

Use of steroids

16 (16%)

0

0

7 (88%)

11 (39%)

0

0

HIV infection

15 (15%)

0

1 (13%)

3 (%)

9 (32%)

1 (9%)

0

Solid organ graft

14 (14%)

0

1 (13%)

4 (50%)

7 (25%)

2 (18%)

0

Coagulation abnormalities

12 (12%)

0

1 (13%)

2 (25%)

5 (18%)

6 (55%)

0

Burns

11 (11%)

0

1 (13%)

3 (38%)

4 (14%)

3 (27%)

0

Renal replacement therapy

11 (11%)

3 (8%)

1 (13%)

1 (13%)

3 (10%)

3 (27%)

0

Overweight

7 (7%)

0

0

0

2 (7%)

4 (36%)

0

Neutropenia

5 (5%)

1 (3%)

0

0

4 (14%)

0

0

Cerebrovascular stroke

3 (3%)

0

1 (13%)

0

0

1 (9%)

0

  1. Results expressed as number (%). Exclusion criteria were not mutually exclusive.