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Table 1 Exclusion criteria from randomized controlled trials dealing with severe sepsis and septic shock

From: Are clinical trials dealing with severe infection fitting routine practices? Insights from a large registry

Exclusion criteria Number (%) of trials (n= 96) Vasopressors (n= 37) Fluid loading (n= 8) Steroids (n= 8) Modulation of immunity (n= 28) Modulation of coagulation (n= 11) Miscellaneous (n= 4)
Pregnancy 46 (47%) 16 (43%) 2 (25%) 4 (50%) 15 (54%) 6 (55%) 4 (100%)
Age <18 years 39 (40%) 7 (19%) 6 (75%) 5 (63%) 13 (46%) 7 (63%) 1 (25%)
Age >75 years 4 (4%) 1 (3%) 1 (13%) 1 (13%) 1 (4%) 0 0
Congestive heart failure 34 (35%) 13 (35%) 2 (25%) 3 (38%) 12 (43%) 2 (18%) 1 (25%)
Cancer 29 (30%) 7 (19%) 2 (25%) 3 (38%) 11 (39%) 6 (55%) 2 (50%)
Gastrointestinal and liver disorder 17 (18%) 6 (16%) 2 (25%) 2 (25%) 6 (21%) 3 (27%) 1 (25%)
Use of steroids 16 (16%) 0 0 7 (88%) 11 (39%) 0 0
HIV infection 15 (15%) 0 1 (13%) 3 (%) 9 (32%) 1 (9%) 0
Solid organ graft 14 (14%) 0 1 (13%) 4 (50%) 7 (25%) 2 (18%) 0
Coagulation abnormalities 12 (12%) 0 1 (13%) 2 (25%) 5 (18%) 6 (55%) 0
Burns 11 (11%) 0 1 (13%) 3 (38%) 4 (14%) 3 (27%) 0
Renal replacement therapy 11 (11%) 3 (8%) 1 (13%) 1 (13%) 3 (10%) 3 (27%) 0
Overweight 7 (7%) 0 0 0 2 (7%) 4 (36%) 0
Neutropenia 5 (5%) 1 (3%) 0 0 4 (14%) 0 0
Cerebrovascular stroke 3 (3%) 0 1 (13%) 0 0 1 (9%) 0
  1. Results expressed as number (%). Exclusion criteria were not mutually exclusive.