Changes from mean baseline values after parenteral diclofenac (zero on X-axis is the first 10-minute-average interval during interventions; n = 123). CPP (▼, baseline = 85 ± 1.4 mm Hg; P < 0.001), ICP (■, baseline, 8.6 ± 0.4 mm Hg); and PbtO2 (●, baseline = 28.1 ± 2.2 mm Hg; P < 0.001). The dotted bar illustrates the median diclofenac infusion time (34 minutes; IQR, 20 to 45). Values are presented in mean ± SEM. CPP, cerebral perfusion pressure; ICP, intracranial pressure; IQR, interquartile range; PbtO2, brain-tissue oxygen tension. Initial CPP decrease after parenteral diclofenac occurred within the first 10 minutes, indicated as point zero at the X-axis.