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Table 2 Hematocrit, plasma protein concentration, oncotic pressure, urine flow, creatinine clearance and antithrombin plasma levels

From: Antithrombin attenuates myocardial dysfunction and reverses systemic fluid accumulation following burn and smoke inhalation injury: a randomized, controlled, experimental study

Variable

Time point

sham

control

rhAT

Hematocrit

BL

27 (22; 29)

24 (23; 27)

26 (21; 26)

(%)

6 h

23 (22; 26)

27 (23; 29)

25 (21; 26)

 

12 h

26 (23; 30)

28 (24; 31)

26 (24; 27)

 

24 h

25 (24; 27)

30 (27; 32)

27 (22; 27)

 

36 h

23 (23; 26)

29 (28; 36)*#

27 (27; 28)

 

48 h

22 (21; 25)

27 (24; 35)

26 (24; 29)

Protein

BL

6.1 (6.0; 6.2)

6.2 (5.8; 6.6)

6.1 (6.0; 6.4)

(g/dL)

6 h

5.7 (5.6; 6.0)

4.9 (4.6; 5.0)*#

5.0 (4.6; 5.4)*#

 

12 h

6.1 (5.9; 6.4)

4.5 (4.4; 4.6)*#

4.9 (4.8; 5.0)*#†

 

24 h

5.9 (5.8; 6.2)

4.0 (4.0; 4.0)*#

4.6 (4.6; 4.6)*#†

 

36 h

5.9 (5.7; 6.2)

3.6 (3.6; 3.9)*#

4.7 (4.6; 5.0)*#†

 

48 h

5.6 (5.6; 5.8)

3.8 (3.5; 3.9)*#

5.0 (4.5; 5.3)*#†

Oncotic pressure

BL

19 (17; 20)

19 (18; 20)

20 (19; 22)

(cmH 2 O)

6 h

18 (16; 19)

13 (12; 14)*#

14 (13; 16)*#

 

12 h

18 (16; 20)

12 (11; 13)*#

14 (13; 15)*#

 

24 h

19 (16; 20)

10 (9; 10)*#

13 (12; 14)*#†

 

36 h

19 (16; 20)

9 (9; 11)*#

13 (13; 15)*#†

 

48 h

17 (15; 18)

9 (9; 10)*#

13 (12; 15)*#†

Urine flow

BL

/

/

/

(mL/kg/h)

6 h

7.7 (6.8; 8.3)

3.4 (2.5; 4.3)#

3.2 (1.6; 4.7)#

 

12 h

7.4 (4.5; 9.0)

2.7 (2.0; 4.5)#

2.7 (2.4; 3.8)#

 

24 h

4.5 (2.7; 5.7)

1.2 (1.1; 2.0)#

4.0 (3.0; 5.2)†

 

36 h

2.3 (2.0; 2.9)

0.6 (0.3; 0.8)#

4.1 (3.7; 5.4)#†

 

48 h

2.4 (2.1; 2.5)

0.8 (0.8; 0.9)#

3.3 (2.6; 3.8)†

Creatinine clearance

BL

/

/

/

(mL/min)

6 h

/

/

/

 

12 h

105 (97; 129)

89 (78; 141)

78 (76; 124)

 

24 h

88 (78; 176)

84 (71; 94)

100 (91; 115)

 

36 h

107 (84; 135)

104 (74; 122)

120 (106; 134)

 

48 h

102 (81; 112)

91 (88; 94)

96 (82; 115)

AT plasma level

BL

86 (83; 89)

79 (72; 82)

87 (73; 93)

(mg/L)

6 h

86 (81; 89)

58 (57; 59)*#

88 (83; 89)†

 

12 h

87 (83; 91)

52 (50; 55)*#

85 (81; 95)†

 

24 h

86 (73; 88)

45 (40; 50)*#

83 (75; 84)†

 

36 h

86 (76; 88)

47 (40; 48)*#

86 (80; 87)†

 

48 h

83 (75; 88)

52 (47; 54)*#

84 (73; 87)†

  1. *, P <0.05 vs. BL; #, P <0.05 vs. sham; † , P <0.05 vs. control; data are represented as median with interquartile range (25th; 75th); each group n = 6
  2. AT, antithrombin; BL, baseline; rhAT, recombinant human antithrombin III