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Table 1 Variables of cardiovascular hemodynamics

From: Antithrombin attenuates myocardial dysfunction and reverses systemic fluid accumulation following burn and smoke inhalation injury: a randomized, controlled, experimental study

Variable

Time point

sham

control

rhAT

CI

BL

6.1 (5.6; 6.7)

5.9 (5.7; 6.7)

6.8 (6.1; 7.8)

(L/min/m 2 )

6 h

6.7 (6.0; 7.5)

6.2 (5.3; 7.2)

6.7 (5.6; 7.5)

 

12 h

6.9 (6.4; 7.0)

6.0 (4.7; 7.4)

7.8 (6.9; 8.4)

 

24 h

7.1 (6.6; 7.4)

5.5 (5.0; 5.6)#

8.0 (6.8; 8.8)†

 

36 h

6.2 (5.4; 7.3)

5.6 (5.3; 6.4)

6.7 (6.3; 7.8)

 

48 h

6.5 (6.4; 6.9)

4.5 (4.4; 7.2)

6.7 (5.8; 7.7)

MAP

BL

97 (93; 98)

101 (93; 113)

105 (96; 110)

(mmHg)

6 h

100 (94; 102)

103 (99; 108)

104 (96; 108)

 

12 h

95 (91; 104)

100 (98; 109)

102 (94; 102)

 

24 h

92 (89; 98)

102 (99; 107)

95 (93; 106)

 

36 h

92 (87; 98)

100 (89; 104)

103 (100; 108)

 

48 h

93 (90; 98)

101 (90; 111)

101(99; 106)

CVP

BL

5 (5; 5)

6 (5; 8)

5 (4; 6)

(mmHg)

6 h

7 (6; 11)

9 (7; 10)

9 (8; 10)

 

12 h

9 (5; 10)

10 (7; 11)

9 (7; 9)

 

24 h

8 (7; 10)

12 (10; 14)*#

7 (5; 11)

 

36 h

10 (7; 11)

13 (12; 14)*#

7 (6; 10)†

 

48 h

9 (9; 11)

11 (7; 13)

6 (5; 8)

LAP

BL

7 (6; 8)

9 (8; 10)

9 (9; 10)

(mmHg)

6 h

9 (9; 9)

9 (7; 11)

10 (8; 12)

 

12 h

12 (11; 12)

11 (9; 13)

11 (9; 12)

 

24 h

11 (10; 12)

12 (11; 13)*

10 (9; 11)

 

36 h

12 (9; 13)

14 (13; 16)*

10 (8; 14)

 

48 h

11 (9; 13)

17 (15; 18)*#

8 (7; 9)†

LVSWI

BL

77 (67; 87)

75 (67; 83)

86 (73; 93)

(g/m/m 2 )

6 h

78 (57; 89)

57 (45; 75)

79 (64; 86)

 

12 h

66 (64; 72)

50 (44; 60)*

74 (60; 91)

 

24 h

67 (59; 77)

35 (34; 37)*#

71 (56; 80)†

 

36 h

71 (65; 76)

35 (31; 43)*#

73 (61; 86)†

 

48 h

73 (72; 76)

43 (42; 55)*#

66 (63; 73)†

RVSWI

BL

13 (13; 14)

12 (10; 15)

13 (11; 15)

(g/m/m 2 )

6 h

13 (11; 17)

13 (10; 15)

13 (11; 17)

 

12 h

16 (14; 17)

13 (11; 16)

16 (14; 18)

 

24 h

15 (15; 17)

9 (8; 11)#

15 (11; 17)

 

36 h

16 (14; 17)

8 (7; 12)#

13 (13; 17)

 

48 h

15 (13; 16)

10 (9; 12)

16 (11; 19)

  1. *, P <0.05 vs. BL; #, P <0.05 vs. sham; † , P <0.05 vs. control; data are represented as median with interquartile range (25th; 75th); each group n = 6
  2. BL, baseline; CI, cardiac index; CVP, central venous pressure; LAP, left atrial pressure; LVSWI, left ventricular stroke work index; MAP, mean arterial pressure; rhAT, recombinant human antithrombin III; RVSWI, right ventricular stroke work index.
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