TY - JOUR AU - Vincent, J. -. L. AU - Rello, J. AU - Marshall, J. AU - Silva, E. AU - Anzueto, A. AU - Martin, C. D. AU - Moreno, R. AU - Lipman, J. AU - Gomersall, C. AU - Sakr, Y. AU - Reinhart, K. PY - 2009 DA - 2009// TI - International study of the prevalence and outcomes of infection in intensive care units JO - JAMA VL - 302 UR - https://doi.org/10.1001/jama.2009.1754 DO - 10.1001/jama.2009.1754 ID - Vincent2009 ER - TY - JOUR AU - Rivers, E. AU - Nguyen, B. AU - Havstad, S. AU - Ressler, J. AU - Muzzin, A. AU - Knoblich, B. AU - Peterson, E. AU - Tomlanovich, M. PY - 2001 DA - 2001// TI - Early goal-directed therapy in the treatment of severe sepsis and septic shock JO - N Engl J Med VL - 345 UR - https://doi.org/10.1056/NEJMoa010307 DO - 10.1056/NEJMoa010307 ID - Rivers2001 ER - TY - JOUR AU - Leibovici, L. AU - Shraga, I. AU - Drucker, M. AU - Konigsberger, H. AU - Samra, Z. AU - Pitlik, S. D. PY - 1998 DA - 1998// TI - The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection JO - J Intern Med VL - 244 UR - https://doi.org/10.1046/j.1365-2796.1998.00379.x DO - 10.1046/j.1365-2796.1998.00379.x ID - Leibovici1998 ER - TY - JOUR AU - Roberts, J. A. AU - Ulldemolins, M. AU - Roberts, M. S. AU - McWhinney, B. AU - Ungerer, J. AU - Paterson, D. L. AU - Lipman, J. PY - 2010 DA - 2010// TI - Therapeutic drug monitoring of beta-lactams in critically ill patients: proof of concept JO - Int J Antimicrob Agents VL - 36 UR - https://doi.org/10.1016/j.ijantimicag.2010.06.008 DO - 10.1016/j.ijantimicag.2010.06.008 ID - Roberts2010 ER - TY - JOUR AU - Taccone, F. S. AU - Laterre, P. -. F. AU - Dugernier, T. AU - Spapen, H. AU - Delattre, I. AU - Wittebole, X. AU - De Backer, D. AU - Layeux, B. AU - Wallemacq, P. AU - Vincent, J. L. AU - Jacobs, F. PY - 2010 DA - 2010// TI - Insufficient beta-lactam concentrations in the early phase of severe sepsis and septic shock JO - Crit Care VL - 14 UR - https://doi.org/10.1186/cc9091 DO - 10.1186/cc9091 ID - Taccone2010 ER - TY - JOUR AU - Navas, D. AU - Caillon, J. AU - Batard, E. AU - Le Conte, P. AU - Kergueris, M. F. AU - Moreau, P. AU - Potel, G. PY - 2006 DA - 2006// TI - Trough serum concentrations of beta-lactam antibiotics in cancer patients: inappropriateness of conventional schedules to pharmacokinetic/pharmacodynamic properties of beta-lactams JO - Int J Antimicrob Agents VL - 27 UR - https://doi.org/10.1016/j.ijantimicag.2005.09.016 DO - 10.1016/j.ijantimicag.2005.09.016 ID - Navas2006 ER - TY - JOUR AU - Roberts, D. M. AU - Roberts, J. A. AU - Roberts, M. S. AU - Liu, X. AU - Nair, P. AU - Cole, L. AU - Lipman, J. AU - Bellomo, R. PY - 2012 DA - 2012// TI - Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: A multicentre pharmacokinetic study* JO - Crit Care Med VL - 40 UR - https://doi.org/10.1097/CCM.0b013e318241e553 DO - 10.1097/CCM.0b013e318241e553 ID - Roberts2012 ER - TY - JOUR AU - Roberts, J. A. AU - Lipman, J. PY - 2009 DA - 2009// TI - Pharmacokinetic issues for antibiotics in the critically ill patient JO - Crit Care Med VL - 37 UR - https://doi.org/10.1097/CCM.0b013e3181961bff DO - 10.1097/CCM.0b013e3181961bff ID - Roberts2009 ER - TY - JOUR AU - Udy, A. A. AU - Putt, M. T. AU - Boots, R. J. AU - Lipman, J. PY - 2011 DA - 2011// TI - ARC - Augmented Renal Clearance JO - Curr Pharm Biotechnol VL - 12 UR - https://doi.org/10.2174/138920111798808446 DO - 10.2174/138920111798808446 ID - Udy2011 ER - TY - JOUR AU - Udy, A. A. AU - Roberts, J. A. AU - Boots, R. J. AU - Paterson, D. L. AU - Lipman, J. PY - 2010 DA - 2010// TI - Augmented renal clearance implications for antibacterial dosing in the critically ill JO - Clin Pharmacokinet VL - 49 UR - https://doi.org/10.2165/11318140-000000000-00000 DO - 10.2165/11318140-000000000-00000 ID - Udy2010 ER - TY - JOUR AU - Fuster-Lluch, O. AU - Geronimo-Pardo, M. AU - Peyro-Garcia, R. AU - Lizan-Garcia, M. PY - 2008 DA - 2008// TI - Glomerular hyperfiltration and albuminuria in critically ill patients JO - Anaesth Intensive Care VL - 36 ID - Fuster-Lluch2008 ER - TY - JOUR AU - Udy, A. AU - Boots, R. AU - Senthuran, S. AU - Stuart, J. AU - Deans, R. AU - Lassig-Smith, M. AU - Lipman, J. PY - 2010 DA - 2010// TI - Augmented creatinine clearance in traumatic brain injury JO - Anesth Analg VL - 111 UR - https://doi.org/10.1213/ANE.0b013e3181f7107d DO - 10.1213/ANE.0b013e3181f7107d ID - Udy2010 ER - TY - JOUR AU - Conil, J. M. AU - Georges, B. AU - Lavit, M. AU - Seguin, T. AU - Tack, I. AU - Samil, K. AU - Chabanon, G. AU - Houin, G. AU - Saivin, S. PY - 2007 DA - 2007// TI - Pharmacokinetics of ceftazidime and cefepime in burn patients: The importance of age and creatinine clearance JO - Int J Clin Pharmacol Ther VL - 45 UR - https://doi.org/10.5414/CPP45529 DO - 10.5414/CPP45529 ID - Conil2007 ER - TY - JOUR AU - Udy, A. A. AU - Varghese, J. M. AU - Altukroni, M. AU - Briscoe, S. AU - McWhinney, B. C. AU - Ungerer, J. P. AU - Lipman, J. AU - Roberts, J. A. PY - 2012 DA - 2012// TI - Subtherapeutic initial beta-lactam concentrations in select critically ill patients association between augmented renal clearance and low trough drug concentrations JO - Chest VL - 142 UR - https://doi.org/10.1378/chest.11-1671 DO - 10.1378/chest.11-1671 ID - Udy2012 ER - TY - JOUR AU - McKinnon, P. S. AU - Paladino, J. A. AU - Schentag, J. J. PY - 2008 DA - 2008// TI - Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections JO - Int J Antimicrob Agents VL - 31 UR - https://doi.org/10.1016/j.ijantimicag.2007.12.009 DO - 10.1016/j.ijantimicag.2007.12.009 ID - McKinnon2008 ER - TY - JOUR AU - McWhinney, B. C. AU - Wallis, S. C. AU - Hillister, T. AU - Roberts, J. A. AU - Lipman, J. AU - Ungerer, J. P. J. PY - 2010 DA - 2010// TI - Analysis of 12 beta-lactam antibiotics in human plasma by HPLC with ultraviolet detection JO - J Chromatogr B VL - 878 UR - https://doi.org/10.1016/j.jchromb.2010.05.027 DO - 10.1016/j.jchromb.2010.05.027 ID - McWhinney2010 ER - TY - STD TI - Antimicrobial wild type distributions of microorganisms[http://mic.eucast.org/Eucast2/SearchController/search.jsp?action=init] UR - http://mic.eucast.org/Eucast2/SearchController/search.jsp?action=init ID - ref17 ER - TY - JOUR AU - Zeitlinger, M. A. AU - Erovic, B. M. AU - Sauermann, R. AU - Georgopoulos, A. AU - Muller, M. AU - Joukhadar, C. PY - 2005 DA - 2005// TI - Plasma concentrations might lead to overestimation of target site activity of piperacillin in patients with sepsis JO - J Antimicrob Chemother VL - 56 UR - https://doi.org/10.1093/jac/dki284 DO - 10.1093/jac/dki284 ID - Zeitlinger2005 ER - TY - JOUR AU - Kitzes-Cohen, R. AU - Farin, D. AU - Piva, G. AU - De Myttenaere-Bursztein, S. A. PY - 2002 DA - 2002// TI - Pharmacokinetics and pharmacodynamics of meropenem in critically ill patients JO - Int J Antimicrob Agents VL - 19 UR - https://doi.org/10.1016/S0924-8579(01)00474-5 DO - 10.1016/S0924-8579(01)00474-5 ID - Kitzes-Cohen2002 ER - TY - JOUR AU - Roos, J. F. AU - Lipman, J. AU - Kirkpatrick, C. M. J. PY - 2007 DA - 2007// TI - Population pharmacokinetics and pharmacodynamics of cefpirome in critically ill patients against Gram-negative bacteria JO - Intensive Care Med VL - 33 UR - https://doi.org/10.1007/s00134-007-0573-7 DO - 10.1007/s00134-007-0573-7 ID - Roos2007 ER - TY - JOUR AU - Angus, B. J. AU - Smith, M. D. AU - Suputtamongkol, Y. AU - Mattie, H. AU - Walsh, A. L. AU - Wuthiekanun, V. AU - Chaowagul, W. AU - White, N. J. PY - 2000 DA - 2000// TI - Pharmacokinetic-pharmacodynamic evaluation of ceftazidime continuous infusion vs intermittent bolus injection in septicaemic melioidosis JO - Br J Clin Pharmacol VL - 49 UR - https://doi.org/10.1046/j.1365-2125.2000.00179.x DO - 10.1046/j.1365-2125.2000.00179.x ID - Angus2000 ER - TY - JOUR AU - Li, C. AU - Kuti, J. L. AU - Nightingale, C. H. AU - Mansfield, D. L. AU - Dana, A. AU - Nicolau, D. P. PY - 2005 DA - 2005// TI - Population pharmacokinetics and pharmacodynamics of piperacillin/tazobactam in patients with complicated intra-abdominal infection JO - J Antimicrob Chemother VL - 56 UR - https://doi.org/10.1093/jac/dki243 DO - 10.1093/jac/dki243 ID - Li2005 ER - TY - JOUR AU - Young, R. J. AU - Lipman, J. AU - Gin, T. AU - Gomersall, C. D. AU - Joynt, G. M. AU - Oh, T. E. PY - 1997 DA - 1997// TI - Intermittent bolus dosing of ceftazidime in critically ill patients JO - J Antimicrob Chemother VL - 40 UR - https://doi.org/10.1093/jac/40.2.269 DO - 10.1093/jac/40.2.269 ID - Young1997 ER - TY - JOUR AU - Tam, V. H. AU - McKinnon, P. S. AU - Akins, R. L. AU - Drusano, G. L. AU - Rybak, M. J. PY - 2003 DA - 2003// TI - Pharmacokinetics and pharmacodynamics of cefepime in patients with various degrees of renal function JO - Antimicrob Agents Chemother VL - 47 UR - https://doi.org/10.1128/AAC.47.6.1853-1861.2003 DO - 10.1128/AAC.47.6.1853-1861.2003 ID - Tam2003 ER - TY - JOUR AU - Lipman, J. AU - Wallis, S. C. AU - Rickard, C. PY - 1999 DA - 1999// TI - Low plasma cefepime levels in critically ill septic patients: Pharmacokinetic modeling indicates improved troughs with revised dosing JO - Antimicrob Agents Chemother VL - 43 ID - Lipman1999 ER - TY - JOUR AU - Lipman, J. AU - Wallis, S. C. AU - Rickard, C. M. AU - Fraenkel, D. PY - 2001 DA - 2001// TI - Low cefpirome levels during twice daily dosing in critically ill septic patients: pharmacokinetic modelling calls for more frequent dosing JO - Intensive Care Med VL - 27 UR - https://doi.org/10.1007/s001340000741 DO - 10.1007/s001340000741 ID - Lipman2001 ER - TY - JOUR AU - Turnidge, J. D. PY - 1998 DA - 1998// TI - The Pharmacodynamics of β-Lactams JO - Clin Infect Dis VL - 27 UR - https://doi.org/10.1086/514622 DO - 10.1086/514622 ID - Turnidge1998 ER - TY - JOUR AU - McKinnon, P. S. AU - Paladino, J. A. AU - Schentag, J. J. PY - 2008 DA - 2008// TI - Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections JO - Int J Antimicrob Agents VL - 31 UR - https://doi.org/10.1016/j.ijantimicag.2007.12.009 DO - 10.1016/j.ijantimicag.2007.12.009 ID - McKinnon2008 ER - TY - JOUR AU - Vogelman, B. AU - Craig, W. A. PY - 1986 DA - 1986// TI - Kinetics of antimicrobial activity JO - J Pediatr VL - 108 UR - https://doi.org/10.1016/S0022-3476(86)80754-5 DO - 10.1016/S0022-3476(86)80754-5 ID - Vogelman1986 ER - TY - JOUR AU - Li, C. AU - Du, X. AU - Kuti, J. L. AU - Nicolau, D. P. PY - 2007 DA - 2007// TI - Clinical pharmacodynamics of meropenem in patients with lower respiratory tract infections JO - Antimicrob Agents Chemother VL - 51 UR - https://doi.org/10.1128/AAC.00294-06 DO - 10.1128/AAC.00294-06 ID - Li2007 ER - TY - JOUR AU - Tröger, U. AU - Drust, A. AU - Martens-Lobenhoffer, J. AU - Tanev, I. AU - Braun-Dullaeus, R. C. AU - Bode-Böger, S. M. PY - 2012 DA - 2012// TI - Decreased meropenem levels in Intensive Care Unit patients with augmented renal clearance: benefit of therapeutic drug monitoring JO - Int J Antimicrob Agents VL - 40 UR - https://doi.org/10.1016/j.ijantimicag.2012.05.010 DO - 10.1016/j.ijantimicag.2012.05.010 ID - Tröger2012 ER - TY - JOUR AU - Udy, A. A. AU - Putt, M. T. AU - Shanmugathasan, S. AU - Roberts, J. A. AU - Lipman, J. PY - 2010 DA - 2010// TI - Augmented renal clearance in the Intensive Care Unit: an illustrative case series JO - Int J Antimicrob Agents VL - 35 UR - https://doi.org/10.1016/j.ijantimicag.2010.02.013 DO - 10.1016/j.ijantimicag.2010.02.013 ID - Udy2010 ER - TY - JOUR AU - Baptista, J. P. AU - Sousa, E. AU - Martins, P. J. AU - Pimentel, J. M. PY - 2012 DA - 2012// TI - Augmented renal clearance in septic patients and implications for vancomycin optimisation JO - Int J Antimicrob Agents VL - 39 UR - https://doi.org/10.1016/j.ijantimicag.2011.12.011 DO - 10.1016/j.ijantimicag.2011.12.011 ID - Baptista2012 ER - TY - JOUR AU - Martin, J. H. AU - Fay, M. F. AU - Udy, A. AU - Roberts, J. AU - Kirkpatrick, C. AU - Ungerer, J. AU - Lipman, J. PY - 2011 DA - 2011// TI - Pitfalls of using estimations of glomerular filtration rate in an intensive care population JO - Intern Med J VL - 41 UR - https://doi.org/10.1111/j.1445-5994.2009.02160.x DO - 10.1111/j.1445-5994.2009.02160.x ID - Martin2011 ER - TY - JOUR AU - Baptista, J. P. AU - Udy, A. A. AU - Sousa, E. AU - Pimentel, J. AU - Wang, L. AU - Roberts, J. A. AU - Lipman, J. PY - 2011 DA - 2011// TI - A comparison of estimates of glomerular filtration in critically ill patients with augmented renal clearance JO - Crit Care VL - 15 UR - https://doi.org/10.1186/cc10262 DO - 10.1186/cc10262 ID - Baptista2011 ER - TY - JOUR AU - Roberts, J. A. AU - Hope, W. W. AU - Lipman, J. PY - 2010 DA - 2010// TI - Therapeutic drug monitoring of beta-lactams for critically ill patients: unwarranted or essential? JO - Int J Antimicrob Agents VL - 35 UR - https://doi.org/10.1016/j.ijantimicag.2010.01.022 DO - 10.1016/j.ijantimicag.2010.01.022 ID - Roberts2010 ER -