Inhaled aerosolized insulin ameliorates hyperglycemia-induced inflammatory responses in the lungs in an experimental model of acute lung injury

Table 1 Arterial blood gas and hemodynamic data

		Baseline	After Injury	One hour after treatment	End of experiment
pH	NG	7.38 ± 0.04	7.35 ± 0.06	7.27 ± 0.04	7.29 ± 0.03
	HG	7.39 ± 0.04	7.34 ± 0.05	7.28 ± 0.05	7.26 ± 0.05
	HG-VI	7.39 ± 0.04	7.37 ± 0.06	7.30 ± 0.03	7.32 ± 0.02
	HG-AI	7.39 ± 0.02	7.33 ± 0.06	7.34 ± 0.05	7.34 ± 0.05
PaCO₂ (mmHg)	NG	40 ± 6	46 ± 12	57 ± 7	58 ± 3
	HG	39 ± 4	49 ± 11	60 ± 5	64 ± 11
	HG-VI	39 ± 4	45 ± 11	47 ± 5	47 ± 6
	HG-AI	38 ± 3	48 ± 5	50 ± 8	53 ± 7
PO₂/FiO₂	NG	620 ± 36	105 ± 25	503 ± 71**	565 ± 62**
	HG	617 ± 16	74 ± 18	420 ± 124**	378 ± 118**
	HG-VI	616 ± 28	77 ± 19	586 ± 68**	609 ± 55** ^#
	HG-AI	637 ± 21	80 ± 21	588 ± 53**	637 ± 13** ^##
HR (beats/minute)	NG	236 ± 34	260 ± 44	254 ± 36	261 ± 42
	HG	259 ± 39	271 ± 34	269 ± 38	253 ± 43
	HG-VI	232 ± 49	249 ± 33	259 ± 24	255 ± 22
	HG-AI	239 ± 21	256 ± 15	270 ± 20	258 ± 32
MAP (mmHg)	NG	90 ± 17	106 ± 28	99 ± 23	88 ± 25
	HG	85 ± 13	106 ± 24	95 ± 20	109 ± 25
	HG-VI	85 ± 7	93 ± 15	71 ± 13	71 ± 18
	HG-AI	90 ± 8	102 ± 7	90 ± 10	103 ± 13

NG, acute lung injury with normoglycemia group; HG, acute lung injury with hyperglycemia group; HG-VI, acute lung injury with hyperglycemia treated with intravenous insulin group; HG-AI, acute lung injury with hyperglycemia treated with aerosolized insulin group; HR, heart rate; MAP, mean arterial pressure. All values are mean ± SD. **P <0.01 compared with after injury; ^##P <0.01, ^#P <0.05 compared with the HG group.

ISSN: 1364-8535