Representative micrograph of histopathology in each experimental group (HE stain ×400). NL, normal healthy control group; NG, acute lung injury with normoglycemia group; HG, acute lung injury with hyperglycemia group; HG-VI, acute lung injury with hyperglycemia treated with intravenous insulin group; HG-AI, acute lung injury with hyperglycemia treated with aerosolized insulin group. Alveolar congestion, edema and infiltration of polymorphonuclear neutrophils were more prominent in the HG group than in other groups. Alveolar congestion, edema had lower scores in the HG-AI group compared with the HG-VI group. Those parameters showed no difference between the NG group and the HG-AI group.