Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia

Table 5 Overexpression of Null or IκBα transgenes does not alter lung function or activate the immune response in animals subjected to sham prolonged pneumonia-induced ALI

Variable	Vehicle	IκBα transgene	Null transgene
Number of animals	4	4	4
Animal weight (g)	411 ± 24	409 ± 14	395 ± 11
Animal survival (n, %)	4 (100%)	4 (100%)	4 (100%)
Duration of animal survival (hours)	72 (72, 72)	72 (72, 72)	72 (72, 72)
Final arterial PO₂ (kPa)	18.3 ± 0.3	17.6 ± 2.5	18.3 ± 0.2
Final static compliance (ml/mm Hg)	0.71 ± 0.07	0.78 ± 0.09	0.75 ± 0.12
BAL protein (mg/L)	961 ± 221	829 ± 226	826 ± 180
BAL neutrophils (× 10³/ml)	1.1 ± 0.7	2.2 ± 1.7	1.4 ± 1.2
BAL mononuclear cells (× 10⁴/ml)	5.5 ± 3.6	5.2 ± 3.9	3.8 ± 2.4

Data are expressed as mean ± SD or median [interquartile range]. Final data are data collected on completion of the experimental protocol. *Significantly different from Vehicle group. BAL, bronchoalveolar lavage; CFU, colony-forming units

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