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Table 5 Overexpression of Null or IκBα transgenes does not alter lung function or activate the immune response in animals subjected to sham prolonged pneumonia-induced ALI

From: Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia

Variable Vehicle IκBα transgene Null transgene
Number of animals 4 4 4
Animal weight (g) 411 ± 24 409 ± 14 395 ± 11
Animal survival (n, %) 4 (100%) 4 (100%) 4 (100%)
Duration of animal survival (hours) 72 (72, 72) 72 (72, 72) 72 (72, 72)
Final arterial PO2 (kPa) 18.3 ± 0.3 17.6 ± 2.5 18.3 ± 0.2
Final static compliance (ml/mm Hg) 0.71 ± 0.07 0.78 ± 0.09 0.75 ± 0.12
BAL protein (mg/L) 961 ± 221 829 ± 226 826 ± 180
BAL neutrophils (× 103/ml) 1.1 ± 0.7 2.2 ± 1.7 1.4 ± 1.2
BAL mononuclear cells (× 104/ml) 5.5 ± 3.6 5.2 ± 3.9 3.8 ± 2.4
  1. Data are expressed as mean ± SD or median [interquartile range]. Final data are data collected on completion of the experimental protocol. *Significantly different from Vehicle group. BAL, bronchoalveolar lavage; CFU, colony-forming units