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Table 4 Data regarding animals subjected to prolonged pneumonia-induced ALI

From: Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia

Variable Vehicle 5 × 109 IκBα 1 × 1010 IκBα 5 × 1010 IκBα
Number of animals 11 11 11 11
Animal weight (g) 383 ± 13 378 ± 19 413 ± 35 401 ± 47
Animal survival (number, %) 8 (73) 9 (82) 9 (82) 8 (73)
Duration of animal survival (hours) 65.5 ± 11.2 64.8 ± 16.2 63.3 ± 19.4 63.3 ± 16.1
Instilled E. coli bacterial load (CFU × 104) 5.0 ± 1.0 5.0 ± 1.0 5.0 ± 1.0 5.0 ± 1.0
Peak airway pressure (mm Hg) 8.1 ± 1.4 6.5 ± 1.0 7.4 ± 1.0 8.0 ± 1.3
Lung homogenate bacterial counts (CFU × 104) 1.1 (0.7, 3.1) 51.3 (3.1, 96)* 20.7 (15.9, 36.2)* 19.3 (16.5, 34.6)*
BAL neutrophils (× 109/ml) 3.7 ± 3.3 2.3 ± 0.8 3.8 ± 2.2 1.7 ± 0.9
BAL mononuclear cells (× 109/ml) 2.3 ± 1.8 0.4 ± 0.2* 0.9 ± 0.6* 0.4 ± 0.2*
  1. Data are expressed as mean ± SD or median (interquartile range). Final data are data collected on completion of the experimental protocol. *Significantly different from Vehicle group. BAL, bronchoalveolar lavage; CFU, colony-forming units.