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Table 3 Overexpression of Null or IκBα transgenes does not alter lung function in animals subjected to sham pneumonia

From: Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia

Variable Vehicle IκBα transgene Null transgene
Number of animals 4 4 4
Animal weight (g) 413 ± 30 426 ± 17 427 ± 19
Animal survival (n, %) 4 (100%) 4 (100%) 4 (100%)
Duration of animal survival (hours) 4 [4, 4] 4 [4, 4] 4 [4, 4]
Final arterial PO2 (kPa) 18.6 ± 0.5 18.4 ± 1.1 19.9 ± 0.7
Final static compliance (ml/mm Hg) 0.65 ± 0.11 0.71 ± 0.17 0.58 ± 0.16
BAL protein (mg/L) 1197 [1061, 1296] 1353 [991, 2167] 1337 [950, 1869]
BAL neutrophils (× 104/ml) 0.2 [0.0, 1.4] 1.3 [0.5, 1.8] 1.1 [0.2, 2.0]
BAL mononuclear cells (× 104/ml) 21.0 [11, 22] 23 [10, 29] 14 [12, 18]
  1. Data are expressed as mean ± SD or median (interquartile range). Final data are data collected on completion of the experimental protocol. *Significantly different from Vehicle group. BAL, bronchoalveolar lavage; CFU, colony-forming units.