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Table 3 Overexpression of Null or IκBα transgenes does not alter lung function in animals subjected to sham pneumonia

From: Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia

Variable

Vehicle

IκBα transgene

Null transgene

Number of animals

4

4

4

Animal weight (g)

413 ± 30

426 ± 17

427 ± 19

Animal survival (n, %)

4 (100%)

4 (100%)

4 (100%)

Duration of animal survival (hours)

4 [4, 4]

4 [4, 4]

4 [4, 4]

Final arterial PO2 (kPa)

18.6 ± 0.5

18.4 ± 1.1

19.9 ± 0.7

Final static compliance (ml/mm Hg)

0.65 ± 0.11

0.71 ± 0.17

0.58 ± 0.16

BAL protein (mg/L)

1197 [1061, 1296]

1353 [991, 2167]

1337 [950, 1869]

BAL neutrophils (× 104/ml)

0.2 [0.0, 1.4]

1.3 [0.5, 1.8]

1.1 [0.2, 2.0]

BAL mononuclear cells (× 104/ml)

21.0 [11, 22]

23 [10, 29]

14 [12, 18]

  1. Data are expressed as mean ± SD or median (interquartile range). Final data are data collected on completion of the experimental protocol. *Significantly different from Vehicle group. BAL, bronchoalveolar lavage; CFU, colony-forming units.