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Table 2 Overexpression of Null transgene does not modulate the severity of acute pneumonia-induced ALI

From: Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia

Variable E. coli+ vehicle E. coli+ null transgene
Number of animals 4 4
Animal weight (g) 443 ± 25 462 ± 33
Bacteria instilled (CFU × 1010) 1.1(0.9, 1.2) 1.2(0.5, 3.6)
Animal survival (n, %) 2 (50%) 2 (50%)
Duration of animal survival (hours) 3.5(2, 4) 3.75 (2.5, 4)
Lung homogenate bacterial counts (CFU × 109) 1.7 (1.4, 3.8) 2.2 (1.2, 3.7)
Final arterial PO2 (kPa) 10.8 ± 0.8 9.3 ± 1.2
Final static compliance (ml/mm Hg) 0.39 ± 0.1 0.39 ± 0.1
BAL protein (mg/L) 7,203 (5,319, 7,646) 5,542 (2,994, 8,554)
BAL neutrophils (× 107/ml) 3.8 (2.1, 5.2) 8.1 (4.6, 11.2)
BAL mononuclear cells (× 107/ml) 0.88 (0.13, 0.72) 1.2 (0.18, 2.0)
  1. Data are expressed as mean ± SD or median (interquartile range). Final data are data collected on completion of the experimental protocol. *Significantly different from Vehicle group. BAL, bronchoalveolar lavage; CFU, colony-forming unit.