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Table 1 Data regarding animals subjected to acute pneumonia-induced ALI

From: Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumonia

Variable Vehicle 5 × 109 IκBα 1 × 1010 IκBα 5 × 1010 IκBα
Number of animals 12 12 12 12
Animal weight (g) 456 ± 55 486 ± 54 469 ± 52 438 ± 86
Bacteria instilled (CFU × 1010) 1.1 ± 0.2 2.1 ± 0.2 2.6 ± 2.0 2.1 ± 2.2
Baseline arterial PO2 (kPa) 18.7 ± 0.5 18.7 ± 0.8 18.8 ± 0.8 18.7 ± 0.8
Baseline static compliance (ml/mm Hg) 0.93 ± 0.1 0.95 ± 0.1 0.99 ± 0.2 0.87 ± 0.2
Animal survival (number, %) 4 (33) 7 (58) 11 (92)* 5 (42)
Duration of animal survival (hours) 2.75(2, 4) 4 (1.5, 4) 4 (4, 4)* 3 (1.75, 4)
Lung homogenate bacterial counts (CFU × 109) 0.8 (0.4, 1.7) 1.4 (0.2, 2.6) 0.6 (0.4, 0.9) 0.7 (0.4, 0.9)
BAL neutrophils (× 107/ml) 5.9 (1.5, 8.4) 3.7 (1.5, 8.9) 6.2 (1.8, 6.7) 8.5 (1.1, 9.1)
BAL mononuclear cells (× 107/ml) 2.2 (1.4, 9.1) 0.57 (2.7, 7.0) 1.5 (1.2, 9.3) 1.8 (1.1, 9.6)
  1. Note: Data are expressed as mean ± SD. *Significantly different from Vehicle group.