Figure 6From: Inhibition of pulmonary nuclear factor kappa-B decreases the severity of acute Escherichia coli pneumonia but worsens prolonged pneumoniaIκBα worsened structural lung injury induced by prolonged pneumonia. Overexpression of IκBα worsened the decrement in alveolar airspace and the increase in alveolar tissue (A) after pneumonia-induced lung injury. (B) Image from a prolonged pneumonia-injured lung that received intratracheal vehicle, demonstrating increased wall thickness and inflammatory cell infiltrate. (C through E) Images from a pneumonia-injured lung that received increasing doses of intratracheal vector encoding the IκBα transgene. The animals that received 1 to 5 × 1010 doses demonstrated greater injury. Vehicle, animals that received intratracheal vehicle alone; IκBα 5 × 109, animals that received 5 × 109 AAV6 particles encoding IκBα; IκBα 1 × 1010, animals that received 1 × 1010 AAV6 particles encoding IκBα; IκBα 5 × 1010, animals that received 5 × 1010 AAV6 particles encoding IκBα. *Significantly different from vehicle group (P < 0.05, ANOVA). Scale bar, 200 μm.Back to article page