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Table 1 Baseline characteristics of patients.

From: Increased survival of cirrhotic patients with septic shock

Characteristic

1997-2004

47 patients

2005-2010

42 patients

P

Age (years, IQR)

55 (46.5-62)

58 (53-65)

0.08

Male gender

36 (76.5)

26 (62)

0.49

Knaus scale

  

0.15

   Mild limitation (B)

6 (12.8)

10 (23.8)

 

   Important limitation (C)

25 (53.2)

17 (40.5)

 

   Severe limitation (D)

16 (34)

15 (35.7)

 

Charlson score (IQR)a

1 (0-1)

1 (0-2)

0.51

Co-morbidities

   

   Chronic heart failure

4 (8.5)

3 (7)

0.81

   COPD

2 (4.3)

3 (7)

0.79

   Diabetes

6 (12.8)

10 (24)

0.27

   Cancer

8 (17)

8 (19)

0.80

   Hepatocellular carcinoma

3

3

 

   Otherb

5

5

 

   Immunosuppressionc

6 (12.8)

2 (4.8)

0.27

Cause of cirrhosisd

   

   Alcohol +/- virus

38 (80.1)

34 (80.1)

1

   Chronic Hepatitis B virus infection

2 (4.3 )

0

0.50

   Chronic Hepatitis C virus infection

6 (12.8)

4 (9.5)

0.74

   Primary biliary cirrhosis

2 (4.3)

2 (4.8)

1

   Undetermined

3 (6.4)

2 (4.8)

1

Persistent alcohol abuse

26 (55.3)

22 (52.3)

0.83

Nosocomial septic shock

13 (27.7)

14 (33.3)

0.67

Primary source of infection

   

   Respiratory

18 (38.3)

19 (45.2)

0.53

   Abdominal

10 (21.3)

16 (38,1)

0.10

Spontaneous peritonitis

8 (17)

14 (33.3)

 

Secondary peritonitis

2 (4.3)

2 (4.8)

 

   Urinary tract

6 (12.8)

4 (9.5)

0.49

   Others

   

CNS

3 (6.4)

0

0.10

Arthritis

1 (2.1)

1(2.4)

1

Isolated bacteriemia

2 (4.2)

0

0.50

Unknown

7 (14.9)

2 (4.8)

0.16

Bacteremia

20 (42.6)

14 (33.3)

0.39

Type of organisms

   

   Gram-positive cocci

15 (31.9)

13 (30.9)

1

   Gram-negative bacilli

17 (36.2)

11 (23.8)

0.25

   Fungi

2 (4.3)

2 (4.8)

1

   Culture negative

12 (25.5)

8 (19)

0.61

   Polymicrobial sepsis

1 (2.1)

8 (19)

0.01

Multi-drug resistant bacteria

2 (4.3)

8 (17)

0.04

  1. Variables are expressed as number (percentage) or median (interquartile range (IQR)). aExcluding liver disease points.
  2. bBreast cancer (n = 3), colon cancer (n = 2), laryngeal cancer (n = 2), cholangiocarcinoma (n = 1), bladder cancer (n = 1), myeloma (n = 1).
  3. cInfection by human immunodeficiency virus (n = 2), multiple myeloma (n = 1), hypogammaglobulinemia (n = 1), treatment with mesalazine (n = 1) and recent chemotherapy for cancer (n = 3).
  4. dSum of causes may exceed the number of patients because of concomitant alcoholic and viral cirrhosis.
  5. CNS, Central Nervous System; COPD, Chronic Pulmonary Obstructive Disease.