Characteristics | Intention-to-treat population | TBI patients | ||
---|---|---|---|---|
 | Saline ( N = 21) | Balanced ( N = 20) | Saline ( N = 18) | Balanced ( N = 18) |
Age (years), median (IQR) | 51 (25 - 68) | 49 (26 - 75) | 47 (28-57) | 49 (27-77) |
Male, N (%) | 15 (71) | 17 (85) | 13 (72) | 16 (89) |
Diagnosis, N (%) | Â | Â | Â | Â |
Traumatic brain injury | 19 (90) | 18 (90) | / | / |
Subarachnoid haemorrhage | 2 (10) | 2 (10) | Â | Â |
Glasgow Coma Scale score on scene, median (IQR) | 8 (7 - 9) | 7 (6 - 9) | 7 (6-8) | 7 (6-8) |
Surgical procedures, N (%) | Â | Â | Â | Â |
Haematoma/contusion evacuation | 9 (43) | 4 (20) | 8 (44) | 4 (22) |
Extraventricular drainage | 2 (10) | 2 (10) | 0 | 0 |
Transfusion, median (IQR) | Â | Â | Â | Â |
Red blood cells, units | 4 (19) | 3 (15) | 4 (22) | 3 (17) |
Fresh frozen plasma, units | 3 (14) | 0 | 3 (17) | 0 |
Norepinephrine infusion on admission, N (%) | 8 (38) | 7 (35) | 7 (39) | 7 (39) |
Fluid infusion prior to inclusion, median (IQR) | Â | Â | Â | Â |
Crystalloids (NaCl 0.9%), ml | 1000 (500 -1000) | 1000 (500 - 1500) | 500 (500 -1000) | 1000 (500 -1500) |
Colloids, ml | 0 (0 - 500) | 0 (0 - 500) | 0 (0 - 500) | 0 (0 - 500) |
Time from brain injury to inclusion (hours) median (IQR) | 5 (3 - 7) | 5 (4 - 12) | 4 (3-6) | 5 (4-6) |
Biological status upon inclusion | Â | Â | Â | Â |
Hyperchloraemic acidosis, N (%) | 4 (19) | 2 (10) | 4 (22) | 2 (11) |
Osmolarity (mOsm/L), median (IQR) | 303 (295 - 319) | 302 (296 - 319) | 306 (299-328) | 306 (300-319) |
Natraemia (mmol/L), median (IQR) | 140 (138-142) | 139 (137-141) | 140 (138-141) | 139 (137-141) |
Chloraemia (mmol/L), median (IQR) | 106 (104 - 110) | 106 (101 - 107) | 106 (104-111) | 106 (100-107) |
Kalemia (mmol/L), median (IQR) | 3.6 (3.4 - 3.9) | 3.7 (3.5 - 4.1) | 3.7 (3.4-3.9) | 3.7 (3.5-4.1) |
Ionized calcaemia (mmol/L), median (IQR) | 1.10 (1.07 - 1.14) | 1.11 (1.07 - 1.18) | 1.10 (1.08-1.12) | 1.11 (1.06-1.18) |
Magnesemia (mmol/L), median (IQR) | 0.86 (0.72 - 0.95) | 0.81 (0.75 - 0.88) | 0.82 (0.76-0.92) | 0.83 (0.73-0.92) |
Phosphoremia (mmol/L), median (IQR) | 0.86 (0.67 - 1.07) | 0.85 (0.74 - 1.14) | 0.88 (0.70-1.10) | 0.82 (0.73-1.13) |
Lactataemia (mmol/L), median (IQR) | 1.4 (1.1 - 2.1) | 1.7 (1.1 - 2.7) | 1.5 (1.2-2.2) | 2.0 (1.1-2.7) |
Azotaemia (μmol/L), median (IQR) | 66 (56-73) | 67 (58-71) | 65 (56-72) | 67 (60-71) |
Albuminaemia (g/L), median (IQR) | 36 (32 - 41) | 37 (34 - 39) | 34 (32-41) | 36 (34-39) |
pH, median (IQR) | 7.38 (7.33 - 7.44) | 7.39 (7.32 - 7.45) | 7.36 (7.31-7.41) | 7.39 (7.31-7.45) |
SID (mmol/L), median (IQR) | 39 (35 - 42) | 39 (39 - 41) | 40 (37-41) | 39 (37-41) |