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Table 2 Baseline characteristicsa

From: Balanced versus chloride-rich solutions for fluid resuscitation in brain-injured patients: a randomised double-blind pilot study

Characteristics Intention-to-treat population TBI patients
  Saline ( N = 21) Balanced ( N = 20) Saline ( N = 18) Balanced ( N = 18)
Age (years), median (IQR) 51 (25 - 68) 49 (26 - 75) 47 (28-57) 49 (27-77)
Male, N (%) 15 (71) 17 (85) 13 (72) 16 (89)
Diagnosis, N (%)     
Traumatic brain injury 19 (90) 18 (90) / /
Subarachnoid haemorrhage 2 (10) 2 (10)   
Glasgow Coma Scale score on scene, median (IQR) 8 (7 - 9) 7 (6 - 9) 7 (6-8) 7 (6-8)
Surgical procedures, N (%)     
Haematoma/contusion evacuation 9 (43) 4 (20) 8 (44) 4 (22)
Extraventricular drainage 2 (10) 2 (10) 0 0
Transfusion, median (IQR)     
Red blood cells, units 4 (19) 3 (15) 4 (22) 3 (17)
Fresh frozen plasma, units 3 (14) 0 3 (17) 0
Norepinephrine infusion on admission, N (%) 8 (38) 7 (35) 7 (39) 7 (39)
Fluid infusion prior to inclusion, median (IQR)     
Crystalloids (NaCl 0.9%), ml 1000 (500 -1000) 1000 (500 - 1500) 500 (500 -1000) 1000 (500 -1500)
Colloids, ml 0 (0 - 500) 0 (0 - 500) 0 (0 - 500) 0 (0 - 500)
Time from brain injury to inclusion (hours) median (IQR) 5 (3 - 7) 5 (4 - 12) 4 (3-6) 5 (4-6)
Biological status upon inclusion     
Hyperchloraemic acidosis, N (%) 4 (19) 2 (10) 4 (22) 2 (11)
Osmolarity (mOsm/L), median (IQR) 303 (295 - 319) 302 (296 - 319) 306 (299-328) 306 (300-319)
Natraemia (mmol/L), median (IQR) 140 (138-142) 139 (137-141) 140 (138-141) 139 (137-141)
Chloraemia (mmol/L), median (IQR) 106 (104 - 110) 106 (101 - 107) 106 (104-111) 106 (100-107)
Kalemia (mmol/L), median (IQR) 3.6 (3.4 - 3.9) 3.7 (3.5 - 4.1) 3.7 (3.4-3.9) 3.7 (3.5-4.1)
Ionized calcaemia (mmol/L), median (IQR) 1.10 (1.07 - 1.14) 1.11 (1.07 - 1.18) 1.10 (1.08-1.12) 1.11 (1.06-1.18)
Magnesemia (mmol/L), median (IQR) 0.86 (0.72 - 0.95) 0.81 (0.75 - 0.88) 0.82 (0.76-0.92) 0.83 (0.73-0.92)
Phosphoremia (mmol/L), median (IQR) 0.86 (0.67 - 1.07) 0.85 (0.74 - 1.14) 0.88 (0.70-1.10) 0.82 (0.73-1.13)
Lactataemia (mmol/L), median (IQR) 1.4 (1.1 - 2.1) 1.7 (1.1 - 2.7) 1.5 (1.2-2.2) 2.0 (1.1-2.7)
Azotaemia (μmol/L), median (IQR) 66 (56-73) 67 (58-71) 65 (56-72) 67 (60-71)
Albuminaemia (g/L), median (IQR) 36 (32 - 41) 37 (34 - 39) 34 (32-41) 36 (34-39)
pH, median (IQR) 7.38 (7.33 - 7.44) 7.39 (7.32 - 7.45) 7.36 (7.31-7.41) 7.39 (7.31-7.45)
SID (mmol/L), median (IQR) 39 (35 - 42) 39 (39 - 41) 40 (37-41) 39 (37-41)
  1. aIQR: interquartile range; TBI: traumatic brain injury; Strong Ion Difference (SID) = (Na + K + Ca + Mg) - (Cl + lactate).