Table 4 Fluid and antibiotic dosage among different groups of BMI
Interventiona mean (SD) |  | < 18.50 Number = 196 | 18.50 to 4.99 Number = 1,020 | 25.0 to 29.99 Number = 816 | 30.0 to 39.99 Number = 680 | ≥ 40 Number = 170 | P value | Adjusted P valueb | Adjusted P valuec |
|---|---|---|---|---|---|---|---|---|---|
Crystalloid | Number = 1,506 (52.3%) | Number = 96 (49.0) | Number = 537 (52.6) | Number = 439 (53.8) | Number = 346 (50.9) | Number = 88 (51.8) | Â | Â | Â |
| Â | Total (ml) | 2,580.3 (1,874.9) | 2,690.0 (2,050.2) | 2,861.7 (2,445.1) | 2,537.4 (2,032.0) | 2,602.3 (1,919.1) | 0.30 | 0.76 | 0.59 |
| Â | Dose per kg of actual body weight (ml/kg) | 55.0 (40.1) | 43.2 (33.4) | 37.1 (30.8) | 27.7 (22.0) | 21.4 (16.8) | < 0.001 | < 0.001 | < 0.001 |
Colloid | Number = 1,506 (52.3%) | Number = 96 (49.0) | Number = 537 (52.6) | Number = 439 (53.8) | Number = 346 (50.9) | Number = 88 (51.8) | Â | Â | Â |
| Â | Total (ml) | 656.8 (864.8) | 509.8 (781.0) | 593.5 (788.7) | 705.5 (2,824.5) | 538.9 (939.8) | 0.44 | 0.79 | 0.31 |
| Â | Dose per kg of actual body weight (ml/kg) | 14.3 (19.3) | 8.2 (12.7) | 7.7 (10.2) | 8.5 (44.2) | 4.3 (7.2) | 0.06 | 0.02 | < 0.001 |
Packed red blood cell | Number = 94 (3.3%) | Number = 5 (2.6) | Number = 29 (2.8) | Number = 31(3.8) | Number = 24 (3.5) | Number = 5 (2.9) | Â | Â | Â |
| Â | Total (ml) | 462.0 (180.7) | 601.0 (630.3) | 522.5 (243.2) | 502.0 (250.0) | 961.2 (781.5) | 0.26 | 0.68 | 0.79 |
| Â | Dose per kg of actual body weight (ml/kg) | 9.6 (4.1) | 9.7 (10.8) | 6.8 (3.1) | 5.4 (3.0) | 7.3 (5.5) | 0.18 | 0.02 | 0.53 |
Fresh frozen plasma | Number 70 (2.4%) | Number = 4 (2.0) | Number = 22 (2.2) | Number = 21(2.6) | Number = 18 (2.6) | Number = 5 (2.9) | Â | Â | Â |
| Â | Total (ml) | 737.5 (715.7) | 498.7 (224.4) | 600.0 (336.9) | 526.8 (333.1) | 1,260.0 (1,34.9) | 0.01 | 0.005 | 0.02 |
| Â | Dose per kg of actual body weight (ml/kg) | 18.9 (20.8) | 8.2 (4.4) | 7.8 (4.7) | 5.8 (3.7) | 10.4 (8.4) | 0.01 | 0.77 | 0.62 |
Piperacillin/tazo-bactam | Number = 564 (19.6%) | Number = 46 (23.5) | Number = 214 (21.0) | Number = 145 (17.8) | Number = 129 (19.0) | Number = 30 (17.6) | Â | Â | Â |
| Â | Total dose (mg) | 10,214.7 (3,216.3) | 10,714.8 (3,155.2) | 11,005.3 (3,074.6) | 10,754.8 (3,264.7) | 10,766.7 (2,699.9) | 0.68 | 0.06 | Â |
| Â | Dose per kg of dosing body weight | 183.5 (66.7) | 174.8 (59.9) | 168.3 (56.1) | 161.0 (59.9) | 133.2 (40.2) | 0.001 | < 0.001 | Â |
Cefotaxime | Number = 772 (26.8%) | Number = 51 (26.0) | Number = 297 (29.1) | Number = 212 (26.0) | Number = 173 (25.4) | Number = 39 (22.9) | Â | Â | Â |
| Â | Total dose (mg) | 3,549.0 (1,932.0) | 3,477.8 (1,821.8) | 3,787.7 (1,857.4) | 3,359.8 (1,531.0) | 4,256.4 (2,220.9) | 0.02 | 0.006 | Â |
| Â | Dose per kg of dosing body weight | 62.1 (38.5) | 56.5 (31.6) | 57.2 (28.7) | 49.7 (24.4) | 53.5 (30.2) | 0.04 | 0.32 | Â |
Imipenem | Number = 242 (8.4%) | Number = 15 (7.7) | Number = 79 (7.7) | Number = 75 (9.2) | Number = 56 (8.2) | Number = 17 (10.0) | Â | Â | Â |
| Â | Total dose (mg) | 1,566.7 (457.7) | 1,665.2 (597.5) | 1,693.3 (700.6) | 1,705.4 (796.5) | 1,426.5 (584.7) | 0.60 | 0.36 | Â |
| Â | Dose per kg of dosing body weight | 25.9 (9.0) | 27.0 (9.9) | 24.9 (10.3) | 24.2 (13.1) | 7.3 (54.6) | 0.002 | < 0.001 | Â |
Gentamycin | Number = 511 (17.7%) | Number = 33 (16.8) | Number = 184 (18.0) | Number = 149 (18.3) | Number = 122 (17.9) | Number = 23 (13.5) | Â | Â | Â |
| Â | Total dose (mg) | 173.3 (82.4) | 219.9 (241.4) | 256.7 (229.4) | 239.4 (118.3) | 262.0 (121.9) | 0.18 | 0.01 | Â |
| Â | Dose per kg of dosing body weight | 3.2 (1.5) | 3.6 (4.0) | 3.8 (3.2) | 3.3 (1.7) | 3.2 (1.6) | 0.63 | 0.96 | Â |
Meropenem | Number = 277 (9.6%) | Number = 19 (9.7) | Number = 83 (8.1) | Number = 85 (10.4) | Number = 70 (10.3) | Number = 20 (11.8) | Â | Â | Â |
| Â | Total dose (mg) | 2,342.1 (1,179.1) | 1,807.2 (791.8) | 1,865.9 (990.6) | 1,678.6 (920.9) | 2,050.0 (916.2) | 0.07 | 0.75 | Â |
| Â | Dose per kg of dosing body weight | 40.7 (19.4) | 29.8 (15.0) | 28.8 (15.7) | 25.0 (15.5) | 26.1 (11.3) | 0.003 | 0.01 | Â |
Levofloxacin | Number = 301 (10.4%) | Number = 28 (14.3) | Number = 110 (10.8) | Number = 81 (9.9) | Number = 62 (9.1) | Number = 20 (11.8) | Â | Â | Â |
| Â | Total dose (mg) | 426.8 (118.2) | 489.8 (164.3) | 488.0 (205.8) | 441.5 (251.8) | 462.5 (91.6) | 0.32 | 0.82 | Â |
| Â | Dose per kg of dosing body weight | 8.0 (2.5) | 8.0 (3.1) | 7.1 (2.8) | 6.2 (4.4) | 5.3 (1.3) | < 0.001 | < 0.001 | Â |
Vancomycin | Number = 771 (26.8%) | Number = 53 (27.0) | Number = 261(25.6) | Number = 209 (25.6) | Number = 194 (28.5) | Number = 54 (32.1) | Â | Â | Â |
| Â | Total dose (mg) | 1,292.5 (521.6) | 1,421.2 (630.3) | 1,380.4 (578.4) | 1,353.1 (623.0) | 1,441.4 (680.6) | 0.54 | 0.20 | Â |
| Â | Dose per kg of dosing body weight | 28.5 (13.7) | 22.9 (11.2) | 17.9 (7.6) | 14.8 (7.2) | 11.3 (5.8) | < 0.001 | < 0.001 | Â |
Ciprofloxacin | Number = 634 (22.0%) | Number = 39 (19.9) | Number = 218 (21.4) | Number = 186 (22.8) | Number = 165 (24.3) | Number = 26 (15.3) | Â | Â | Â |
| Â | Total dose (mg) | 682.9 (280.3) | 674.4 (237.0) | 671.4 (255.8) | 670.3 (363.1) | 682.7 (210.2) | 1.0 | 0.13 | Â |
| Â | Dose per kg of dosing body weight | 13.0 (5.2) | 10.9 (4.4) | 10.1 (4.1) | 9.1 (5.0) | 7.6 (2.6) | < 0.001 | < 0.001 | Â |
Ampicillin | Number = 340 (11.8%) | Number = 19 (9.7) | Number = 122 (12.0) | Number = 115 (14.1) | Number = 70 (10.3) | Number = 14 (8.2) | Â | Â | Â |
| Â | Total dose (mg) | 4,106.6 (1,788.6) | 4,002.3 (1,940.8) | 4,326.1 (2,019.7) | 4,072.1 (1,64.0) | 5,071.4 (2,302.7) | 0.31 | 0.01 | Â |
| Â | Dose per kg of dosing body weight | 71.8 (38.4) | 64.8 (32.2) | 66.5 (33.0) | 61.3 (31.0) | 67.0 (36.3) | 0.74 | 0.85 | Â |
Amphotericin B | Number = 102 (3.5%) | Number = 5 (2.6) | Number = 34 (3.3) | Number = 36 (0.4) | Number = 25 (3.7) | Number = 2 (1.2) | Â | Â | Â |
| Â | Total dose (mg) | 3,897.2 (4,330.8) | 5,531.1 (3,998.5) | 6,866.2 (5,977.6) | 5,079.2 (4,933.2) | 10,520.0 (10,521.7) | 0.35 | 0.53 | Â |
| Â | Dose per kg of dosing body weight | 85.4 (91.9) | 84.9 (59.7) | 90.9 (80.2) | 54.3 (52.4) | 83.5 (86.7) | 0.33 | 0.15 | Â |
Ceftazidime | Number = 292 (10.1%) | Number = 25 (1.3) | Number = 106 (10.4) | Number = 89 (10.9) | Number = 58 (8.5) | Number = 14 (8.2) | Â | Â | Â |
| Â | Total dose (mg) | 2,710.0 (1,154.0) | 3,547.2 (1,867.7) | 2,995.3 (1,691.5) | 3,025.9 (1,590.6) | 3,285.7 (1,683.8) | 0.08 | 0.10 | Â |
| Â | Dose per kg of dosing body weight | 47.2 (18.3) | 57.5 (30.7) | 46.9 (28.0) | 43.9 (23.6) | 42.7 (17.7) | 0.01 | 0.48 | Â |
Ceftriaxone | Number = 232 (8.0%) | Number = 12 (6.1) | Number = 77 (7.5) | Number = 67 (7.6) | Number = 58 (8.5) | Number = 18 (10.6) | Â | Â | Â |
| Â | Total dose (mg) | 1,666.7 (492.4) | 1,655.8 (1,052.1) | 1,776.1 (884.6) | 1,672.4 (943.8) | 1,611.1 (607.7) | 0.93 | 0.77 | Â |
| Â | Dose per kg of dosing body weight | 31.9 (10.2) | 26.1 (14.4) | 27.5 (12.7) | 24.6 (13.7) | 21.5 (8.7) | 0.20 | 0.02 | Â |
Cefuroxime | Number = 772 (26.8%) | Number = 19 (9.7) | Number = 74 (7.3) | Number = 68 (8.3) | Number = 55 (8.1) | Number = 11(6.5) | Â | Â | Â |
| Â | Total dose (mg) | 2,578.9 (920.6) | 2,171.8 (1,063.2) | 2,216.9 (808.0) | 2,386.4 (842.7) | 2,181.8 (975.3) | 0.39 | 0.68 | Â |
| Â | Dose per kg of dosing body weight | 45.3 (18.9) | 35.1 (17.0) | 32.7 (12.9) | 34.6 (15.0) | 26.7 (12.1) | 0.01 | 0.02 | Â |