Skip to main content

Table 4 Fluid and antibiotic dosage among different groups of BMI

From: Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study

Interventiona
mean (SD)
  < 18.50
Number = 196
18.50 to 4.99
Number = 1,020
25.0 to 29.99
Number = 816
30.0 to 39.99
Number = 680
≥ 40
Number = 170
P value Adjusted P valueb Adjusted
P valuec
Crystalloid Number = 1,506 (52.3%) Number = 96 (49.0) Number = 537 (52.6) Number = 439 (53.8) Number = 346 (50.9) Number = 88 (51.8)    
  Total (ml) 2,580.3 (1,874.9) 2,690.0 (2,050.2) 2,861.7 (2,445.1) 2,537.4 (2,032.0) 2,602.3 (1,919.1) 0.30 0.76 0.59
  Dose per kg of actual body weight (ml/kg) 55.0 (40.1) 43.2 (33.4) 37.1 (30.8) 27.7 (22.0) 21.4 (16.8) < 0.001 < 0.001 < 0.001
Colloid Number = 1,506 (52.3%) Number = 96 (49.0) Number = 537 (52.6) Number = 439 (53.8) Number = 346 (50.9) Number = 88 (51.8)    
  Total (ml) 656.8 (864.8) 509.8 (781.0) 593.5 (788.7) 705.5 (2,824.5) 538.9 (939.8) 0.44 0.79 0.31
  Dose per kg of actual body weight (ml/kg) 14.3 (19.3) 8.2 (12.7) 7.7 (10.2) 8.5 (44.2) 4.3 (7.2) 0.06 0.02 < 0.001
Packed red blood cell Number = 94 (3.3%) Number = 5 (2.6) Number = 29 (2.8) Number = 31(3.8) Number = 24 (3.5) Number = 5 (2.9)    
  Total (ml) 462.0 (180.7) 601.0 (630.3) 522.5 (243.2) 502.0 (250.0) 961.2 (781.5) 0.26 0.68 0.79
  Dose per kg of actual body weight (ml/kg) 9.6 (4.1) 9.7 (10.8) 6.8 (3.1) 5.4 (3.0) 7.3 (5.5) 0.18 0.02 0.53
Fresh frozen plasma Number 70 (2.4%) Number = 4 (2.0) Number = 22 (2.2) Number = 21(2.6) Number = 18 (2.6) Number = 5 (2.9)    
  Total (ml) 737.5 (715.7) 498.7 (224.4) 600.0 (336.9) 526.8 (333.1) 1,260.0 (1,34.9) 0.01 0.005 0.02
  Dose per kg of actual body weight (ml/kg) 18.9 (20.8) 8.2 (4.4) 7.8 (4.7) 5.8 (3.7) 10.4 (8.4) 0.01 0.77 0.62
Piperacillin/tazo-bactam Number = 564 (19.6%) Number = 46 (23.5) Number = 214 (21.0) Number = 145 (17.8) Number = 129 (19.0) Number = 30 (17.6)    
  Total dose (mg) 10,214.7 (3,216.3) 10,714.8 (3,155.2) 11,005.3 (3,074.6) 10,754.8 (3,264.7) 10,766.7 (2,699.9) 0.68 0.06  
  Dose per kg of dosing body weight 183.5 (66.7) 174.8 (59.9) 168.3 (56.1) 161.0 (59.9) 133.2 (40.2) 0.001 < 0.001  
Cefotaxime Number = 772 (26.8%) Number = 51 (26.0) Number = 297 (29.1) Number = 212 (26.0) Number = 173 (25.4) Number = 39 (22.9)    
  Total dose (mg) 3,549.0 (1,932.0) 3,477.8 (1,821.8) 3,787.7 (1,857.4) 3,359.8 (1,531.0) 4,256.4 (2,220.9) 0.02 0.006  
  Dose per kg of dosing body weight 62.1 (38.5) 56.5 (31.6) 57.2 (28.7) 49.7 (24.4) 53.5 (30.2) 0.04 0.32  
Imipenem Number = 242 (8.4%) Number = 15 (7.7) Number = 79 (7.7) Number = 75 (9.2) Number = 56 (8.2) Number = 17 (10.0)    
  Total dose (mg) 1,566.7 (457.7) 1,665.2 (597.5) 1,693.3 (700.6) 1,705.4 (796.5) 1,426.5 (584.7) 0.60 0.36  
  Dose per kg of dosing body weight 25.9 (9.0) 27.0 (9.9) 24.9 (10.3) 24.2 (13.1) 7.3 (54.6) 0.002 < 0.001  
Gentamycin Number = 511 (17.7%) Number = 33 (16.8) Number = 184 (18.0) Number = 149 (18.3) Number = 122 (17.9) Number = 23 (13.5)    
  Total dose (mg) 173.3 (82.4) 219.9 (241.4) 256.7 (229.4) 239.4 (118.3) 262.0 (121.9) 0.18 0.01  
  Dose per kg of dosing body weight 3.2 (1.5) 3.6 (4.0) 3.8 (3.2) 3.3 (1.7) 3.2 (1.6) 0.63 0.96  
Meropenem Number = 277 (9.6%) Number = 19 (9.7) Number = 83 (8.1) Number = 85 (10.4) Number = 70 (10.3) Number = 20 (11.8)    
  Total dose (mg) 2,342.1 (1,179.1) 1,807.2 (791.8) 1,865.9 (990.6) 1,678.6 (920.9) 2,050.0 (916.2) 0.07 0.75  
  Dose per kg of dosing body weight 40.7 (19.4) 29.8 (15.0) 28.8 (15.7) 25.0 (15.5) 26.1 (11.3) 0.003 0.01  
Levofloxacin Number = 301 (10.4%) Number = 28 (14.3) Number = 110 (10.8) Number = 81 (9.9) Number = 62 (9.1) Number = 20 (11.8)    
  Total dose (mg) 426.8 (118.2) 489.8 (164.3) 488.0 (205.8) 441.5 (251.8) 462.5 (91.6) 0.32 0.82  
  Dose per kg of dosing body weight 8.0 (2.5) 8.0 (3.1) 7.1 (2.8) 6.2 (4.4) 5.3 (1.3) < 0.001 < 0.001  
Vancomycin Number = 771 (26.8%) Number = 53 (27.0) Number = 261(25.6) Number = 209 (25.6) Number = 194 (28.5) Number = 54 (32.1)    
  Total dose (mg) 1,292.5 (521.6) 1,421.2 (630.3) 1,380.4 (578.4) 1,353.1 (623.0) 1,441.4 (680.6) 0.54 0.20  
  Dose per kg of dosing body weight 28.5 (13.7) 22.9 (11.2) 17.9 (7.6) 14.8 (7.2) 11.3 (5.8) < 0.001 < 0.001  
Ciprofloxacin Number = 634 (22.0%) Number = 39 (19.9) Number = 218 (21.4) Number = 186 (22.8) Number = 165 (24.3) Number = 26 (15.3)    
  Total dose (mg) 682.9 (280.3) 674.4 (237.0) 671.4 (255.8) 670.3 (363.1) 682.7 (210.2) 1.0 0.13  
  Dose per kg of dosing body weight 13.0 (5.2) 10.9 (4.4) 10.1 (4.1) 9.1 (5.0) 7.6 (2.6) < 0.001 < 0.001  
Ampicillin Number = 340 (11.8%) Number = 19 (9.7) Number = 122 (12.0) Number = 115 (14.1) Number = 70 (10.3) Number = 14 (8.2)    
  Total dose (mg) 4,106.6 (1,788.6) 4,002.3 (1,940.8) 4,326.1 (2,019.7) 4,072.1 (1,64.0) 5,071.4 (2,302.7) 0.31 0.01  
  Dose per kg of dosing body weight 71.8 (38.4) 64.8 (32.2) 66.5 (33.0) 61.3 (31.0) 67.0 (36.3) 0.74 0.85  
Amphotericin B Number = 102 (3.5%) Number = 5 (2.6) Number = 34 (3.3) Number = 36 (0.4) Number = 25 (3.7) Number = 2 (1.2)    
  Total dose (mg) 3,897.2 (4,330.8) 5,531.1 (3,998.5) 6,866.2 (5,977.6) 5,079.2 (4,933.2) 10,520.0 (10,521.7) 0.35 0.53  
  Dose per kg of dosing body weight 85.4 (91.9) 84.9 (59.7) 90.9 (80.2) 54.3 (52.4) 83.5 (86.7) 0.33 0.15  
Ceftazidime Number = 292 (10.1%) Number = 25 (1.3) Number = 106 (10.4) Number = 89 (10.9) Number = 58 (8.5) Number = 14 (8.2)    
  Total dose (mg) 2,710.0 (1,154.0) 3,547.2 (1,867.7) 2,995.3 (1,691.5) 3,025.9 (1,590.6) 3,285.7 (1,683.8) 0.08 0.10  
  Dose per kg of dosing body weight 47.2 (18.3) 57.5 (30.7) 46.9 (28.0) 43.9 (23.6) 42.7 (17.7) 0.01 0.48  
Ceftriaxone Number = 232 (8.0%) Number = 12 (6.1) Number = 77 (7.5) Number = 67 (7.6) Number = 58 (8.5) Number = 18 (10.6)    
  Total dose (mg) 1,666.7 (492.4) 1,655.8 (1,052.1) 1,776.1 (884.6) 1,672.4 (943.8) 1,611.1 (607.7) 0.93 0.77  
  Dose per kg of dosing body weight 31.9 (10.2) 26.1 (14.4) 27.5 (12.7) 24.6 (13.7) 21.5 (8.7) 0.20 0.02  
Cefuroxime Number = 772 (26.8%) Number = 19 (9.7) Number = 74 (7.3) Number = 68 (8.3) Number = 55 (8.1) Number = 11(6.5)    
  Total dose (mg) 2,578.9 (920.6) 2,171.8 (1,063.2) 2,216.9 (808.0) 2,386.4 (842.7) 2,181.8 (975.3) 0.39 0.68  
  Dose per kg of dosing body weight 45.3 (18.9) 35.1 (17.0) 32.7 (12.9) 34.6 (15.0) 26.7 (12.1) 0.01 0.02  
  1. aCrystalloid, colloid, crystalloid equivalent volume, red blood cell and fresh frozen plasma for first six hours. All others for day 1. bAdjusted for creatinine clearance. cAdjusted for creatinine clearance and pulmonary capillary wedge pressure. BMI, body mass index.