# Table 4 Fluid and antibiotic dosage among different groups of BMI

Interventiona

mean (SD)

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< 18.50

Number = 196

18.50 to 4.99

Number = 1,020

25.0 to 29.99

Number = 816

30.0 to 39.99

Number = 680

â‰¥ 40

Number = 170

P value

P valuec

Crystalloid

Number = 1,506 (52.3%)

Number = 96 (49.0)

Number = 537 (52.6)

Number = 439 (53.8)

Number = 346 (50.9)

Number = 88 (51.8)

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Total (ml)

2,580.3 (1,874.9)

2,690.0 (2,050.2)

2,861.7 (2,445.1)

2,537.4 (2,032.0)

2,602.3 (1,919.1)

0.30

0.76

0.59

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Dose per kg of actual body weight (ml/kg)

55.0 (40.1)

43.2 (33.4)

37.1 (30.8)

27.7 (22.0)

21.4 (16.8)

< 0.001

< 0.001

< 0.001

Colloid

Number = 1,506 (52.3%)

Number = 96 (49.0)

Number = 537 (52.6)

Number = 439 (53.8)

Number = 346 (50.9)

Number = 88 (51.8)

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Total (ml)

656.8 (864.8)

509.8 (781.0)

593.5 (788.7)

705.5 (2,824.5)

538.9 (939.8)

0.44

0.79

0.31

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Dose per kg of actual body weight (ml/kg)

14.3 (19.3)

8.2 (12.7)

7.7 (10.2)

8.5 (44.2)

4.3 (7.2)

0.06

0.02

< 0.001

Packed red blood cell

Number = 94 (3.3%)

Number = 5 (2.6)

Number = 29 (2.8)

Number = 31(3.8)

Number = 24 (3.5)

Number = 5 (2.9)

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Total (ml)

462.0 (180.7)

601.0 (630.3)

522.5 (243.2)

502.0 (250.0)

961.2 (781.5)

0.26

0.68

0.79

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Dose per kg of actual body weight (ml/kg)

9.6 (4.1)

9.7 (10.8)

6.8 (3.1)

5.4 (3.0)

7.3 (5.5)

0.18

0.02

0.53

Fresh frozen plasma

Number 70 (2.4%)

Number = 4 (2.0)

Number = 22 (2.2)

Number = 21(2.6)

Number = 18 (2.6)

Number = 5 (2.9)

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Total (ml)

737.5 (715.7)

498.7 (224.4)

600.0 (336.9)

526.8 (333.1)

1,260.0 (1,34.9)

0.01

0.005

0.02

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Dose per kg of actual body weight (ml/kg)

18.9 (20.8)

8.2 (4.4)

7.8 (4.7)

5.8 (3.7)

10.4 (8.4)

0.01

0.77

0.62

Piperacillin/tazo-bactam

Number = 564 (19.6%)

Number = 46 (23.5)

Number = 214 (21.0)

Number = 145 (17.8)

Number = 129 (19.0)

Number = 30 (17.6)

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Total dose (mg)

10,214.7 (3,216.3)

10,714.8 (3,155.2)

11,005.3 (3,074.6)

10,754.8 (3,264.7)

10,766.7 (2,699.9)

0.68

0.06

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Dose per kg of dosing body weight

183.5 (66.7)

174.8 (59.9)

168.3 (56.1)

161.0 (59.9)

133.2 (40.2)

0.001

< 0.001

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Cefotaxime

Number = 772 (26.8%)

Number = 51 (26.0)

Number = 297 (29.1)

Number = 212 (26.0)

Number = 173 (25.4)

Number = 39 (22.9)

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Total dose (mg)

3,549.0 (1,932.0)

3,477.8 (1,821.8)

3,787.7 (1,857.4)

3,359.8 (1,531.0)

4,256.4 (2,220.9)

0.02

0.006

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Dose per kg of dosing body weight

62.1 (38.5)

56.5 (31.6)

57.2 (28.7)

49.7 (24.4)

53.5 (30.2)

0.04

0.32

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Imipenem

Number = 242 (8.4%)

Number = 15 (7.7)

Number = 79 (7.7)

Number = 75 (9.2)

Number = 56 (8.2)

Number = 17 (10.0)

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Total dose (mg)

1,566.7 (457.7)

1,665.2 (597.5)

1,693.3 (700.6)

1,705.4 (796.5)

1,426.5 (584.7)

0.60

0.36

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Dose per kg of dosing body weight

25.9 (9.0)

27.0 (9.9)

24.9 (10.3)

24.2 (13.1)

7.3 (54.6)

0.002

< 0.001

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Gentamycin

Number = 511 (17.7%)

Number = 33 (16.8)

Number = 184 (18.0)

Number = 149 (18.3)

Number = 122 (17.9)

Number = 23 (13.5)

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Total dose (mg)

173.3 (82.4)

219.9 (241.4)

256.7 (229.4)

239.4 (118.3)

262.0 (121.9)

0.18

0.01

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Dose per kg of dosing body weight

3.2 (1.5)

3.6 (4.0)

3.8 (3.2)

3.3 (1.7)

3.2 (1.6)

0.63

0.96

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Meropenem

Number = 277 (9.6%)

Number = 19 (9.7)

Number = 83 (8.1)

Number = 85 (10.4)

Number = 70 (10.3)

Number = 20 (11.8)

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Total dose (mg)

2,342.1 (1,179.1)

1,807.2 (791.8)

1,865.9 (990.6)

1,678.6 (920.9)

2,050.0 (916.2)

0.07

0.75

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Dose per kg of dosing body weight

40.7 (19.4)

29.8 (15.0)

28.8 (15.7)

25.0 (15.5)

26.1 (11.3)

0.003

0.01

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Levofloxacin

Number = 301 (10.4%)

Number = 28 (14.3)

Number = 110 (10.8)

Number = 81 (9.9)

Number = 62 (9.1)

Number = 20 (11.8)

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Total dose (mg)

426.8 (118.2)

489.8 (164.3)

488.0 (205.8)

441.5 (251.8)

462.5 (91.6)

0.32

0.82

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Dose per kg of dosing body weight

8.0 (2.5)

8.0 (3.1)

7.1 (2.8)

6.2 (4.4)

5.3 (1.3)

< 0.001

< 0.001

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Vancomycin

Number = 771 (26.8%)

Number = 53 (27.0)

Number = 261(25.6)

Number = 209 (25.6)

Number = 194 (28.5)

Number = 54 (32.1)

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Total dose (mg)

1,292.5 (521.6)

1,421.2 (630.3)

1,380.4 (578.4)

1,353.1 (623.0)

1,441.4 (680.6)

0.54

0.20

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Dose per kg of dosing body weight

28.5 (13.7)

22.9 (11.2)

17.9 (7.6)

14.8 (7.2)

11.3 (5.8)

< 0.001

< 0.001

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Ciprofloxacin

Number = 634 (22.0%)

Number = 39 (19.9)

Number = 218 (21.4)

Number = 186 (22.8)

Number = 165 (24.3)

Number = 26 (15.3)

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Total dose (mg)

682.9 (280.3)

674.4 (237.0)

671.4 (255.8)

670.3 (363.1)

682.7 (210.2)

1.0

0.13

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Dose per kg of dosing body weight

13.0 (5.2)

10.9 (4.4)

10.1 (4.1)

9.1 (5.0)

7.6 (2.6)

< 0.001

< 0.001

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Ampicillin

Number = 340 (11.8%)

Number = 19 (9.7)

Number = 122 (12.0)

Number = 115 (14.1)

Number = 70 (10.3)

Number = 14 (8.2)

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Total dose (mg)

4,106.6 (1,788.6)

4,002.3 (1,940.8)

4,326.1 (2,019.7)

4,072.1 (1,64.0)

5,071.4 (2,302.7)

0.31

0.01

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Dose per kg of dosing body weight

71.8 (38.4)

64.8 (32.2)

66.5 (33.0)

61.3 (31.0)

67.0 (36.3)

0.74

0.85

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Amphotericin B

Number = 102 (3.5%)

Number = 5 (2.6)

Number = 34 (3.3)

Number = 36 (0.4)

Number = 25 (3.7)

Number = 2 (1.2)

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Total dose (mg)

3,897.2 (4,330.8)

5,531.1 (3,998.5)

6,866.2 (5,977.6)

5,079.2 (4,933.2)

10,520.0 (10,521.7)

0.35

0.53

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Dose per kg of dosing body weight

85.4 (91.9)

84.9 (59.7)

90.9 (80.2)

54.3 (52.4)

83.5 (86.7)

0.33

0.15

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Ceftazidime

Number = 292 (10.1%)

Number = 25 (1.3)

Number = 106 (10.4)

Number = 89 (10.9)

Number = 58 (8.5)

Number = 14 (8.2)

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Total dose (mg)

2,710.0 (1,154.0)

3,547.2 (1,867.7)

2,995.3 (1,691.5)

3,025.9 (1,590.6)

3,285.7 (1,683.8)

0.08

0.10

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Dose per kg of dosing body weight

47.2 (18.3)

57.5 (30.7)

46.9 (28.0)

43.9 (23.6)

42.7 (17.7)

0.01

0.48

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Ceftriaxone

Number = 232 (8.0%)

Number = 12 (6.1)

Number = 77 (7.5)

Number = 67 (7.6)

Number = 58 (8.5)

Number = 18 (10.6)

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Total dose (mg)

1,666.7 (492.4)

1,655.8 (1,052.1)

1,776.1 (884.6)

1,672.4 (943.8)

1,611.1 (607.7)

0.93

0.77

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Dose per kg of dosing body weight

31.9 (10.2)

26.1 (14.4)

27.5 (12.7)

24.6 (13.7)

21.5 (8.7)

0.20

0.02

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Cefuroxime

Number = 772 (26.8%)

Number = 19 (9.7)

Number = 74 (7.3)

Number = 68 (8.3)

Number = 55 (8.1)

Number = 11(6.5)

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Total dose (mg)

2,578.9 (920.6)

2,171.8 (1,063.2)

2,216.9 (808.0)

2,386.4 (842.7)

2,181.8 (975.3)

0.39

0.68

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Dose per kg of dosing body weight

45.3 (18.9)

35.1 (17.0)

32.7 (12.9)

34.6 (15.0)

26.7 (12.1)

0.01

0.02

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1. aCrystalloid, colloid, crystalloid equivalent volume, red blood cell and fresh frozen plasma for first six hours. All others for day 1. bAdjusted for creatinine clearance. cAdjusted for creatinine clearance and pulmonary capillary wedge pressure. BMI, body mass index.