Table 3 Sepsis interventions related to septic shock among the five groups of BMI
Variable | < 18.50 Number = 196 | 18.50 to 24.99 Umber = 1,020 | 25.0 to 29.99 Number = 816 | 30.0 to 39.99 Number = 680 | ≥ 40 Number = 170 | P value |
|---|---|---|---|---|---|---|
Vasopressors used, Number (%) | ||||||
   Dopamine | 117 (59.7) | 594 (58.2) | 465 (57.0) | 408 (60.0) | 91 (53.5) | 0.54 |
   Norepinephrine | 122 (62.2) | 566 (55.5) | 480 (58.8) | 362 (53.2) | 86 (50.6) | 0.04 |
   Phenylephrine | 58 (29.6) | 336 (32.9) | 255 (31.3) | 219 (32.2) | 48 (28.2) | 0.70 |
   Epinephrine | 12 (6.1) | 45 (4.4) | 41 (5.0) | 31 (4.6) | 15 (8.8) | 0.15 |
   Dobutamine | 16 (8.2) | 98 (9.6) | 84 (10.3) | 75 (11.0) | 18 (10.6) | 0.77 |
Vasopressor dose - at six hours, mean (SD) | ||||||
   Dopamine (μcg/kg/minute) | 7.7 (7.3) | 6.7 (4.9) | 6.5 (4.7) | 6.4 (4.3) | 6.2 (5.1) | 0.22 |
   Norepinephrine (μcg/kg/minute) | 0.39 (0.41) | 0.37 (0.60) | 0.33 (0.43) | 0.30 (0.47) | 0.18 (0.18) | 0.05 |
   Phenylephrine (μcg/kg/minute) | 3.4 (4.1) | 2.2 (2.1) | 2.1 (2.3) | 2.0 (2.4) | 1.2 (1.4) | 0.003 |
   Epinephrine (μcg/kg/minute) | 0.85 (0.61) | 0.30 (0.26) | 0.33 (0.73) | 0.18 (0.12) | 0.21 (0.18) | 0.04 |
   Dobutamine (μcg/kg/minute) | 5.1 (1.7) | 4.4 (2.5) | 4.7 (2.9) | 4.0 (2.8) | 4.4 (2.5) | 0.82 |
Sepsis specific therapy | ||||||
   Activated protein C, number (%) | 9 (4.6) | 36 (3.5) | 29 (3.6) | 42 (6.2) | 13 (7.7) | 0.01 |
   Low-dose steroids, number (%) | 73 (37.2) | 305 (29.9) | 256 (31.4) | 222 (32.7) | 46 (27.1) | 0.19 |
   Inappropriate antimicrobials therapy, number (%) | 46 (23.5) | 188 (18.4) | 160 (19.6) | 120 (17.7) | 31 (18.2) | 0.43 |
   Single versus combined antimicrobial therapy, number (%) | 142 (72.5) | 711 (69.7) | 568 (69.6) | 456 (67.1) | 118 (69.4) | 0.62 |
   Delay in antimicrobial therapy, mean (SD) | 17.8 (30.3) | 13.9 (24.0) | 15.1 (26.0) | 12.6 (18.8) | 16.7 (29.9) | 0.12 |
Others | ||||||
   Pulmonary artery catheter, number (%) | 91 (46.4) | 513 (50.3) | 428 (52.5) | 386 (56.8) | 89 (52.4) | 0.04 |
   Pulmonary capillary wedge pressure, (mmHG), mean (SD) | 15.0 (5.2) | 16.5 (6.1) | 17.6 (6.1) | 18.6 (6.4) | 20.5 (6.7) | < 0.001 |
   Cardiac output (L/minute), mean (SD) | 6.4 (2.8) | 7.1 (3.2) | 7.6 (3.2) | 7.7 (3.4) | 8.7 (3.5) | < 0.001 |
   Cardiac index(L/minute/m2), mean (SD) | 4.1 (1.7) | 4.1 (1.7) | 4.0 (1.6) | 3.8 (1.5) | 3.9 (1.5) | 0.11 |