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Table 2 Microbiologic and sites of infection among different groups of BMI

From: Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study

Number (%)

< 18.50

Number = 196

18.50 to 24.99

Number = 1,020

25.0 to29.99

Number = 816

30.0 to 39.99

Number = 680

≥ 40

Number = 170

P value

Total culture negative

49 (25.0)

270 (26.5)

242 (29.7)

204 (30.0)

53 (31.2)

0.28

Total culture positive

147 (75.0)

750 (73.5)

574 (70.3)

476 (70.0)

117 (68.8)

 

Gram-negative organisms

72 (36.7)

384 (37.7)

281 (34.4)

230 (33.8)

45 (26.5)

0.05

   Escherichia coli

23 (11.7)

163 (16.0)

115 (14.1)

97 (14.3)

19 (1.2)

0.32

   Klebsiella

16 (8.2)

62 (6.1)

41 (5.0)

36 (5.3)

7 (4.1)

0.38

   Pseudomonas aeruginosa

13 (6.6)

68 (6.7)

48 (5.9)

28 (4.1)

8 (4.7)

0.23

   Enterobacter species

5 (2.6)

27 (2.7)

21 (2.6)

25 (3.7)

1 (0.6)

0.25

   Haemophilus influenzae

6 (3.1)

12 (1.2)

10 (1.2)

8 (1.2)

3 (1.8)

0.29

   Acinetobacter species

4 (2.0)

10 (1.0)

6 (0.8)

11 (1.6)

2 (1.2)

0.38

   Other Gram-negative bacilli

5 (2.6)

42 (4.1)

40 (4.9)

25 (3.7)

5 (2.9)

0.49

Gram-positive organisms

41 (20.9)

247 (24.2)

183 (22.4)

168 (24.7)

60 (35.3)

0.007

   Staphylococcus aureus

19 (9.7)

110 (10.8)

81 (9.9)

71 (10.4)

22 (12.9)

0.81

   Streptococcus pneumonia

9 (4.6)

60 (5.9)

37 (4.5)

37 (5.4)

8 (4.7)

0.74

   Streptococci faecalis

4 (2.0)

19 (1.9)

17 (2.1)

17 (2.5)

6 (3.5)

0.68

   Streptococcus faecium

2 (1.0)

11 (1.1)

8 (1.0)

4 (0.6)

3 (1.8)

0.69

   Group A streptococcus species

2 (1.0)

18 (1.8)

17 (2.1)

14 (2.1)

10 (5.9)

0.01

   Other β-hemolytic streptococci

3 (1.5)

12 (1.2)

10 (1.2)

13 (1.9)

8 (4.7)

0.01

   Other Gram-positive bacilli

2 (1.0)

17 (1.7)

13 (1.6)

12 (1.8)

3 (1.8)

0.97

Fungi/Yeast

20 (10.2)

77 (7.6)

84 (10.3)

62 (9.1)

8 (4.7)

0.08

   Candida albicans

11 (5.6)

44 (4.3)

50 (6.1)

37 (5.4)

7 (4.1)

0.46

   Other candida/yeast

9 (4.6)

33 (3.2)

34 (4.2)

25 (3.7)

1 (0.6)

0.18

Anaerobes

10 (5.1)

26 (2.6)

17 (2.1)

14 (2.1)

4 (2.4)

0.15

Other organisms

4 (2.0)

16 (1.6)

9 (1.1)

2 (0.3)

0

0.04

Site of infection

      

Lung

95 (48.5)

445 (43.6)

301 (36.9)

226 (33.2)

53 (31.2)

< 0.001

   Pneumonia

91 (46.4)

435 (42.7)

296 (36.3)

223 (32.8)

51 (30.0)

0.45

   Empyema

4 (2.0)

10 (1.0)

5 (0.6)

3 (0.4)

2 (1.2)

0.22

Intraabdominal

53 (27.0)

299 (29.3)

268 (32.8)

228 (33.5)

53 (31.2)

0.20

   Intraabdominal abscess

5 (2.6)

23 (2.3)

23 (2.8)

28 (4.1)

8 (4.7)

0.15

   Ascending Cholangitis

2 (1.0)

23 (2.3)

14 (1.7)

13 (1.9)

0

0.28

   Cholecystitis

1 (0.5)

9 (0.9)

14 (1.7)

12 (1.8)

1 (0.6)

0.26

   Ischemic bowel/bowel infarction

7 (3.6)

48 (4.7)

51 (6.3)

35 (5.2)

5 (2.9)

0.27

   Viscous bowel perforation

21 (10.7)

104 (10.2)

104 (12.8)

66 (9.7)

20 (11.8)

0.34

   Spontaneous bacterial peritonitis

3 (1.5)

31 (3.0)

14 (1.7)

17 (2.5)

1 (0.6)

0.16

   Clostridium difficile enterocolitis/toxic megacolon

7 (3.6)

25 (2.5)

18 (2.2)

12 (1.8)

2 (1.2)

0.49

   Infected pancreatic necrosis

0

4 (0.4)

11 (1.4)

16 (2.4)

3 (1.8)

0.002

   Others

7 (3.6)

32 (3.1)

19 (2.3)

29 (4.3)

13 (7.7)

0.009

Skin and soft tissue

14 (7.1)

69 (6.8)

72 (8.8)

79 (11.6)

37 (21.8)

< 0.001

   Cellulitis

2 (1.0)

7 (0.7)

11 (1.4)

19 (2.8)

12 (7.1)

< 0.001

   Necrotizing soft tissue infections

5 (2.6)

20 (2.0)

16 (2.0)

23 (3.4)

12 (7.1)

0.001

   Others

7 (3.6)

42 (4.1)

45 (5.5)

37 (5.4)

13 (7.7)

0.22

Genitourinary

17 (8.7)

92 (9.0)

80 (9.8)

70 (10.3)

18 (10.6)

0.88

Intravascular catheter infection

8 (4.1)

38 (3.7)

29 (3.6)

36 (5.3)

6 (3.5)

0.46

Primary bloodstream infection (bacteremia without identifiable source)

8 (4.1)

49 (4.8)

44 (5.4)

37 (5.4)

7 (4.1)

0.87

Systemically disseminated infection (including yeast and tuberculosis)

6 (3.1)

29 (2.8)

26 (3.2)

18 (2.7)

5 (2.9)

0.98

Septic arthritis

0

5 (0.5)

7 (0.9)

7 (1.0)

6 (3.5)

0.002

  1. BMI, body mass index.