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Table 1 Baseline characteristics among different groups of BMI

From: Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study

Variables < 18.50
Number = 196
18.50 to 24.99
Number = 1,020
25.0 to 29.99
Number = 816
30.0 to -39.99
Number = 680
≥ 40
Number = 170
P value
Age (years), mean (SD) 59.1 (19.2) 62.2 (16.8) 63.5 (15.9) 62.2 (14.6) 58.4 (13.0) < 0.001
Gender, female, number (%) 82 (41.8) 390 (38.2) 316 (38.7) 334 (49.1) 102 (60.0) < 0.001
Actual body weight (kg), mean (SD) 47.3 (7.1) 63.4 (10.2) 77.3 (10.1) 93.4 (14.7) 128.9 (28.1) < 0.001
Ideal body weight (kg), mean (SD) 61.7 (10.9) 62.9 (11.5) 62.4 (10.7) 60.4 (12.0) 58.3 (13.4) < 0.001
Dosing body weight (kg), mean (SD) 58.1 (9.7) 63.0 (10.9) 66.1 (10.4) 68.6 (12.3) 75.9 (15.8) < 0.001
Height (cms), mean (SD) 167.3 (10.6) 168.8 (11.1) 167.9 (10.1) 166.3 (11.5) 164.5 (13.3) < 0.001
BMI (kg/m2), mean (SD) 16.8 (1.3) 22.2 (1.8) 27.3 (1.4) 33.6 (2.7) 47.4 (7.4) < 0.001
Mechanical ventilation, number (%) 146 (74.5) 777 (76.2) 605 (74.1) 491 (72.2) 128 (75.3) 0.48
APACHE II, mean (SD) 25.5 (8.0) 25.7 (8.1) 25.6 (8.4) 25.4 (7.9) 24.4(7.3) 0.43
Admission physiologic data, mean (SD)       
   Heart rate (beats/minute) 120.9 (30.3) 119.2 (29.4) 116.7 (29.9) 119.1 (29.5) 112.2 (31.0) 0.02
   Respiratory rate (beats/minute) 29.0 (8.8) 27.0 (10.2) 26.6 (10.4) 26.0 (10.0) 25.8 (9.1) 0.005
   Temperature (°C) 37.2 (1.8) 37.5 (1.7) 37.7 (1.7) 37.8 (1.6) 37.8 (1.7) < 0.001
   Mean arterial pressure (mmHg) 53.3 (13.3) 56.6 (16.5) 58.0 (19.0) 60.3 (20.1) 62.6 (22.2) < 0.001
Co-morbidities, number (%)       
   Immunosuppressive disorder 56 (28.6) 300 (29.4) 213 (26.1) 188 (27.7) 32 (18.8) 0.06
   Liver failure 14 (7.1) 91 (8.9) 67 (8.2) 53 (7.8) 19 (11.2) 0.59
   New York Heart Association class IV heart failure 16 (8.2) 70 (6.9) 95 (11.6) 77 (11.3) 21 (12.4) 0.002
   Severe COPD (requiring medication or oxygen) 22 (11.2) 102 (10.0) 88 (10.8) 83 (12.2) 32 (18.8) 0.02
   Chronic renal failurea 35 (17.9) 155 (15.2) 126 (15.4) 100 (14.7) 34 (20.0) 0.43
   Chronic renal failure-dialysis dependence 17 (8.7) 81 (7.9) 45 (5.5) 41 (6.0) 12 (7.1) 0.20
   Diabetes mellitus (medication dependent) 10 (5.1) 127 (12.5) 141 (17.3) 159 (23.4) 45 (26.5) < 0.001
   Diabetes mellitus (insulin-dependent) 11 (5.6) 76 (7.5) 82 (10.1) 80 (11.8) 35 (20.6) < 0.001
   Alcohol abuse 29 (14.8) 162 (15.9) 107 (13.1) 76 (11.2) 15 (8.8) 0.02
   Elective surgery 28 (14.3) 160 (15.7) 159 (19.5) 130 (19.1) 25 (14.7) 0.09
   Emergency surgery/trauma 17 (8.7) 97 (9.5) 73 (9.0) 49 (7.2) 8 (4.7) 0.19
   No co-morbidity 58 (29.6) 285 (27.9) 227 (27.8) 170 (25.0) 38 (22.4) 0.33
   Any co-morbidity 138 (70.4) 735 (72.1) 589 (72.2) 510 (75.0) 132 (77.6)  
Laboratory findings on day-1, mean (SD)       
   White blood count (×109/L) 16.1 (16.4) 16.1 (15.3) 16.5 (16.9) 17.9 (16.1) 16.0 (10.6) 0.20
   Creatinine (μmol/L) 164.3 (148.2) 195.3 (160.6) 207.7 (167.9) 221.7 (165.2) 242.3 (201.8) < 0.001
   Bicarbonate (mmol/L) 19.4 (6.7) 19.1 (6.4) 18.8 (6.4) 19.0 (6.7) 20.1 (6.1) 0.32
   Bilirubin (μmol/L) 33.2 (54.4) 41.5 (76.3) 44.1 (92.5) 41.5 (68.1) 31.1 (76.0) 0.29
   Platelets (×109/L) 206.9 (140.5) 198.4 (156.6) 185.6 (133.3) 210.3 (140.6) 223.5 (132.2) 0.004
   International normalized ratio 1.8 (1.2) 1.7 (1.1) 1.8 (1.1) 1.8 (1.4) 1.7 (1.3) 0.78
Creatinine clearance (mL/minute), mean (SD)       
   MDRDb equation 85.9 (148.2) 56.5 (49.3) 48.1 (40.6) 43.1 (36.0) 37.1 (27.6) < 0.001
   Cockcroft-Gault equation 69.6 (98.6) 49.8 (41.3) 42.3 (34.3) 37.9 (29.9) 33.6 (22.7) < 0.001
Source of infection, number (%)       
   Community acquired infection 102 (52.0) 555 (54.4) 410 (50.3) 350 (51.5) 105 (61.8) 0.06
   Nosocomial infection 94 (48.0) 465 (45.6) 406 (49.8) 330 (48.5) 65 (38.2)  
Bacteremia, Number (%) 68 (34.7) 361 (35.4) 289 (35.4) 266 (39.1) 48 (28.2) 0.10
Organ failures on day-1, number (%)       
   Cardiovascular 196 (100) 1020 (100) 816 (100) 680 (100) 170 (100) *
   Renal 80 (40.8) 550 (53.9) 501 (61.4) 447 (65.7) 112 (65.9) < 0.001
   Respiratory 146 (74.5) 777 (76.2) 605 (74.1) 491 (72.2) 128 (75.3) 0.48
   Hematologic 56 (28.6) 261 (25.6) 241 (29.5) 163 (24.0) 29 (17.1) 0.006
   Metabolic 110 (56.1) 551 (54.0) 441 (54.0) 367 (54.0) 91 (53.5) 1.00
   Central nervous system 47 (24.0) 289 (28.3) 210 (25.7) 168 (24.7) 45 (26.5) 0.44
   Hepatic 32 (16.3) 195 (19.1) 157 (19.2) 144 (21.2) 31 (18.2) 0.60
   Coagulation 89 (45.4) 454 (44.5) 350 (42.9) 284 (41.8) 69 (40.6) 0.70
Country, number (%)       
   Canada 147 (75.0) 813 (79.7) 655 (80.3) 548 (80.6) 130 (76.5) 0.15
   USA 28 (14.3) 101 (9.9) 90 (11.0) 75 (11.0) 28 (16.5)  
   Saudi Arabia 21 (10.7) 106 (10.4) 71 (8.7) 57 (8.4) 12 (7.1)  
Period, number (%)       
   ≤ 1997 57 (29.1) 301 (29.5) 218 (26.7) 191 (28.1) 32 (18.8) 0.18
   1998 to 2000 72 (36.7) 378 (37.1) 292 (35.8) 235 (34.6) 67 (39.4)  
   2001 to 2002 57 (29.1) 296 (29.0) 265 (32.5) 207 (30.4) 62 (36.5)  
   ≥ 2003 10 (5.1) 45 (4.4) 41 (5.0) 47 (6.9) 9 (5.3)  
  1. APACHE II, Acute Physiology and Chronic Health Evaluation II; BMI, body mass index;aSerum creatinine > 1.5 upper limit of normal,
  2. aSerum creatinine > 1.5 upper limit of normal = Chronic renal failure
  3. bMDRD: Modification of diet in renal disease