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Table 1 Baseline characteristics among different groups of BMI

From: Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study

Variables

< 18.50

Number = 196

18.50 to 24.99

Number = 1,020

25.0 to 29.99

Number = 816

30.0 to -39.99

Number = 680

≥ 40

Number = 170

P value

Age (years), mean (SD)

59.1 (19.2)

62.2 (16.8)

63.5 (15.9)

62.2 (14.6)

58.4 (13.0)

< 0.001

Gender, female, number (%)

82 (41.8)

390 (38.2)

316 (38.7)

334 (49.1)

102 (60.0)

< 0.001

Actual body weight (kg), mean (SD)

47.3 (7.1)

63.4 (10.2)

77.3 (10.1)

93.4 (14.7)

128.9 (28.1)

< 0.001

Ideal body weight (kg), mean (SD)

61.7 (10.9)

62.9 (11.5)

62.4 (10.7)

60.4 (12.0)

58.3 (13.4)

< 0.001

Dosing body weight (kg), mean (SD)

58.1 (9.7)

63.0 (10.9)

66.1 (10.4)

68.6 (12.3)

75.9 (15.8)

< 0.001

Height (cms), mean (SD)

167.3 (10.6)

168.8 (11.1)

167.9 (10.1)

166.3 (11.5)

164.5 (13.3)

< 0.001

BMI (kg/m2), mean (SD)

16.8 (1.3)

22.2 (1.8)

27.3 (1.4)

33.6 (2.7)

47.4 (7.4)

< 0.001

Mechanical ventilation, number (%)

146 (74.5)

777 (76.2)

605 (74.1)

491 (72.2)

128 (75.3)

0.48

APACHE II, mean (SD)

25.5 (8.0)

25.7 (8.1)

25.6 (8.4)

25.4 (7.9)

24.4(7.3)

0.43

Admission physiologic data, mean (SD)

      

   Heart rate (beats/minute)

120.9 (30.3)

119.2 (29.4)

116.7 (29.9)

119.1 (29.5)

112.2 (31.0)

0.02

   Respiratory rate (beats/minute)

29.0 (8.8)

27.0 (10.2)

26.6 (10.4)

26.0 (10.0)

25.8 (9.1)

0.005

   Temperature (°C)

37.2 (1.8)

37.5 (1.7)

37.7 (1.7)

37.8 (1.6)

37.8 (1.7)

< 0.001

   Mean arterial pressure (mmHg)

53.3 (13.3)

56.6 (16.5)

58.0 (19.0)

60.3 (20.1)

62.6 (22.2)

< 0.001

Co-morbidities, number (%)

      

   Immunosuppressive disorder

56 (28.6)

300 (29.4)

213 (26.1)

188 (27.7)

32 (18.8)

0.06

   Liver failure

14 (7.1)

91 (8.9)

67 (8.2)

53 (7.8)

19 (11.2)

0.59

   New York Heart Association class IV heart failure

16 (8.2)

70 (6.9)

95 (11.6)

77 (11.3)

21 (12.4)

0.002

   Severe COPD (requiring medication or oxygen)

22 (11.2)

102 (10.0)

88 (10.8)

83 (12.2)

32 (18.8)

0.02

   Chronic renal failurea

35 (17.9)

155 (15.2)

126 (15.4)

100 (14.7)

34 (20.0)

0.43

   Chronic renal failure-dialysis dependence

17 (8.7)

81 (7.9)

45 (5.5)

41 (6.0)

12 (7.1)

0.20

   Diabetes mellitus (medication dependent)

10 (5.1)

127 (12.5)

141 (17.3)

159 (23.4)

45 (26.5)

< 0.001

   Diabetes mellitus (insulin-dependent)

11 (5.6)

76 (7.5)

82 (10.1)

80 (11.8)

35 (20.6)

< 0.001

   Alcohol abuse

29 (14.8)

162 (15.9)

107 (13.1)

76 (11.2)

15 (8.8)

0.02

   Elective surgery

28 (14.3)

160 (15.7)

159 (19.5)

130 (19.1)

25 (14.7)

0.09

   Emergency surgery/trauma

17 (8.7)

97 (9.5)

73 (9.0)

49 (7.2)

8 (4.7)

0.19

   No co-morbidity

58 (29.6)

285 (27.9)

227 (27.8)

170 (25.0)

38 (22.4)

0.33

   Any co-morbidity

138 (70.4)

735 (72.1)

589 (72.2)

510 (75.0)

132 (77.6)

 

Laboratory findings on day-1, mean (SD)

      

   White blood count (×109/L)

16.1 (16.4)

16.1 (15.3)

16.5 (16.9)

17.9 (16.1)

16.0 (10.6)

0.20

   Creatinine (μmol/L)

164.3 (148.2)

195.3 (160.6)

207.7 (167.9)

221.7 (165.2)

242.3 (201.8)

< 0.001

   Bicarbonate (mmol/L)

19.4 (6.7)

19.1 (6.4)

18.8 (6.4)

19.0 (6.7)

20.1 (6.1)

0.32

   Bilirubin (μmol/L)

33.2 (54.4)

41.5 (76.3)

44.1 (92.5)

41.5 (68.1)

31.1 (76.0)

0.29

   Platelets (×109/L)

206.9 (140.5)

198.4 (156.6)

185.6 (133.3)

210.3 (140.6)

223.5 (132.2)

0.004

   International normalized ratio

1.8 (1.2)

1.7 (1.1)

1.8 (1.1)

1.8 (1.4)

1.7 (1.3)

0.78

Creatinine clearance (mL/minute), mean (SD)

      

   MDRDb equation

85.9 (148.2)

56.5 (49.3)

48.1 (40.6)

43.1 (36.0)

37.1 (27.6)

< 0.001

   Cockcroft-Gault equation

69.6 (98.6)

49.8 (41.3)

42.3 (34.3)

37.9 (29.9)

33.6 (22.7)

< 0.001

Source of infection, number (%)

      

   Community acquired infection

102 (52.0)

555 (54.4)

410 (50.3)

350 (51.5)

105 (61.8)

0.06

   Nosocomial infection

94 (48.0)

465 (45.6)

406 (49.8)

330 (48.5)

65 (38.2)

 

Bacteremia, Number (%)

68 (34.7)

361 (35.4)

289 (35.4)

266 (39.1)

48 (28.2)

0.10

Organ failures on day-1, number (%)

      

   Cardiovascular

196 (100)

1020 (100)

816 (100)

680 (100)

170 (100)

*

   Renal

80 (40.8)

550 (53.9)

501 (61.4)

447 (65.7)

112 (65.9)

< 0.001

   Respiratory

146 (74.5)

777 (76.2)

605 (74.1)

491 (72.2)

128 (75.3)

0.48

   Hematologic

56 (28.6)

261 (25.6)

241 (29.5)

163 (24.0)

29 (17.1)

0.006

   Metabolic

110 (56.1)

551 (54.0)

441 (54.0)

367 (54.0)

91 (53.5)

1.00

   Central nervous system

47 (24.0)

289 (28.3)

210 (25.7)

168 (24.7)

45 (26.5)

0.44

   Hepatic

32 (16.3)

195 (19.1)

157 (19.2)

144 (21.2)

31 (18.2)

0.60

   Coagulation

89 (45.4)

454 (44.5)

350 (42.9)

284 (41.8)

69 (40.6)

0.70

Country, number (%)

      

   Canada

147 (75.0)

813 (79.7)

655 (80.3)

548 (80.6)

130 (76.5)

0.15

   USA

28 (14.3)

101 (9.9)

90 (11.0)

75 (11.0)

28 (16.5)

 

   Saudi Arabia

21 (10.7)

106 (10.4)

71 (8.7)

57 (8.4)

12 (7.1)

 

Period, number (%)

      

   ≤ 1997

57 (29.1)

301 (29.5)

218 (26.7)

191 (28.1)

32 (18.8)

0.18

   1998 to 2000

72 (36.7)

378 (37.1)

292 (35.8)

235 (34.6)

67 (39.4)

 

   2001 to 2002

57 (29.1)

296 (29.0)

265 (32.5)

207 (30.4)

62 (36.5)

 

   ≥ 2003

10 (5.1)

45 (4.4)

41 (5.0)

47 (6.9)

9 (5.3)

 
  1. APACHE II, Acute Physiology and Chronic Health Evaluation II; BMI, body mass index;aSerum creatinine > 1.5 upper limit of normal,
  2. aSerum creatinine > 1.5 upper limit of normal = Chronic renal failure
  3. bMDRD: Modification of diet in renal disease