Table 1 Daily dose medians, trough and PK/PD data
Parameter | Initial dose | Adjusted dose | P value |
|---|---|---|---|
Daily dose (mg/kg/day) | 28.6 | 42.9 | 0.01 |
Trough levels (μg/ml) | 7.1(3.6 to 13.3) | 16.0 (12.0 to 23.3) | <0.001 |
AUC/MIC (MIC: 1 mg/l) | 436 (248 to 659) | 648 (467 to 942) | 0.02 |