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Table 1 Daily dose medians, trough and PK/PD data

From: Vancomycin dose adjustment in severe burn patients based on trough level for drug effectiveness against pathogens at 1 mg/l minimum inhibitory concentration

Parameter Initial dose Adjusted dose P value
Daily dose (mg/kg/day) 28.6 42.9 0.01
Trough levels (μg/ml) 7.1(3.6 to 13.3) 16.0 (12.0 to 23.3) <0.001
AUC/MIC (MIC: 1 mg/l) 436 (248 to 659) 648 (467 to 942) 0.02
  1. Data presented as median (25 to 75% percentile).