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Table 1 Pharmacokinetic parameters of tedizolid in control and renal impaired subjects

From: A phase 1 study of intravenously administered TR-701 FA in subjects with advanced renal impairment

 

Geometric mean (GM)

90% Cl

TR-700

Advanced renal impairment

Control

GM ratio

Lower

Upper

AUC0-t (μg·hour/ml)

28.4

30.7

0.93

0.70

1.23

AUC0-∞ (μg·hour/ml)

28.7

31.0

0.92

0.70

1.23

Cmax (μg/ml)

3.01

3.02

0.99

0.78

1.27