Table 1 Characteristics of the studies included in the meta-analysis
Author | Year | Sample | Male (%) | Population | PSA type | Treatment arms | Durationa (days) | Main outcomes | Definition of infection | Scoreb |
|---|---|---|---|---|---|---|---|---|---|---|
Randomized controlled trials | ||||||||||
Zabramski and colleagues [6] | 2003 | 288 | 48.6 | Adult | PAE | M/R-impregnated catheter; standard catheter | 8.2 vs. 8.5 | CSF infection (%); bacterial colonization (%); organism analyses; complications (%) | CC (+) | Jadad: R2 B2 A0 = 4 |
Wong and colleagues [12] | 2010 | 184 | 59 | Adult | Impregnated: PA; standard: PAE | C/R-impregnated catheter; standard catheter | 10 vs. 10 | Nosocomial infection (%); CSF infection (%); length of ICU and hospital stay; functional outcome; organism analyses | CC (+) and CWC (+)/CP (+)/CG (+) | Jadad: R1 B2 A1 = 4 |
Pople and colleagues [13] | 2012 | 357 | 47.6 | Adult | PAE | M/R-impregnated catheter; standard catheter | 9.3 vs. 9.7 | Proven CSF infection (%); suspected CSF infection (%); time to infection; bacteria colonization (%); organism analyses | CC (+) and CS (+); CC (+), CS (+), CWC (+); C (+) | Jadad: R2 B2 A1 = 5 |
Har Keong and colleagues [7] | 2012 | 325 | 52.2 | Adult | Not used | Silver-impregnated catheter; standard catheter | NA | CSF infection (%); secondary VP shunt (%) | CC (+) or (CM (+) and CWC (+)) | Jadad: R2 B2 A1 = 5 |
Nonrandomized prospective studies | ||||||||||
Lackner and colleagues [8] | 2008 | 39 | 30.8 | Adult | PA or PAE (optional) | Silver-impregnated catheter; standard catheter | 15.5 vs. 14 | Catheter-associated ventriculitis (%); bacterial colonization (%) | CC (+) | NOS: S3C1O3 = 7 |
Tamburrini and colleagues [10] | 2008 | 91 | NA | Pediatric | PAE | C/R-impregnated catheter; standard catheter | NA | Positive CSF culture (%); CSF infection (%); ETV success rate (%); organism analyses | CC (+) | NOS: S3C1O3 = 7 |
Muttaiyah and colleagues [9] | 2010 | 120 | 45 | Adult + pediatric | NA | C/R-impregnated catheter; standard | 7 vs. 6.5 | EVD-associated ventriculitis (%); positive CSF culture (%); median time to ventriculitis; organism analyses; cost-effectiveness | CC (+) and CWC (+) | NOS: S3C2O3 = 8 |
Harrop and colleagues [26] | 2010 | 1,634 | NA | Adult | PA | C/R-impregnated catheter; M/R-impregnated catheter; standard catheter | NA | Ventriculostomy infection (%); organism analyses | CC (+) and CWC (+) | NOS: S4C0O2 = 6 |