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Figure 5 | Critical Care

Figure 5

From: Hepatic excretory function in sepsis: implications from biophotonic analysis of transcellular xenobiotic transport in a rodent model

Figure 5

Transcutaneous whole-body near-infrared fluorescence (NIRF) imaging of ICG enables non-invasive assessment of impaired hepatobiliary excretion in polymicrobial sepsis. Fifteen hours post induction of sepsis, ICG fluorescence was assessed transcutaneously by a whole body NIRF imaging device over a time period of 300 minutes (semi-quantitative analysis, n = 5 animals/group) at the indicated timepoints. *P < 0.05 for sham versus sepsis (90.min: P = 0.019; 150.min: P = 0.001; 300.min: P = 0.005). Kinetics of emitted fluorescence intensities of ICG detected in (A) the liver region or (B) the bowel region of the abdomen. While different fluorescence intensities between sham and septic animals could not be demonstrated in the liver region, fluorescence intensities in the bowel region significantly differed between sham and septic animals. This hints towards a substantial impairment of biliary ICG excretion in septic animals. ICG, indocyanine green.

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Critical Care

ISSN: 1364-8535