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Figure 3 | Critical Care

Figure 3

From: Hepatic excretory function in sepsis: implications from biophotonic analysis of transcellular xenobiotic transport in a rodent model

Figure 3

Effects of polymicrobial sepsis on biliary excretion of two xenobiotics (DY635, ICG). Kinetics of (A) DY635 and (C) ICG with respect to biliary excretion in sham-operated as opposed to septic rats over an observation period of 30 minutes after intravenous administration (14 pmol/g; n = 6 animals/group; 15 hours after induction of sepsis). Cumulative biliary excretion of (B) DY635 and (D) ICG, respectively. *P < 0.05 for sham versus sepsis (DY635: P ≤ 0.001; ICG: P = 0.013). In septic animals biliary recovery of the two dyes was significantly reduced. ICG, indocyanine green.

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Critical Care

ISSN: 1364-8535