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Table 5 Factors associated with time to mortality, right censored at 28 days, by the Cox model in the study population of 1,488 patients with septic shock (EPISS study - 2009 to 2011).

From: The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study

  Univariate Cox models Full Cox model Final Cox model
  HR (95%CI) P HR (95%CI) P HR (95%CI) P
Age (per additional 10 years) 1.19 (1.13-1.28) <10-4 1.27 (1.19-1.36) <10-4 1.27 (1.18-1.36) <10-4
Females (vs. males) 0.85 (0.72-1.01) 0.062 0.99 (0.84-1.18) 0.942 --  
BMI (kg/m²)       
   <20 vs. 20.25 1.08 (0.79-1.46) 0.641 --   --  
   25-30 vs. 20-25 0.94 (0.76-1.18) 0.614 --   --  
   >30 vs. 20-25 0.86 (0.68-1.09) 0.222 --   --  
   Unknown vs. 20-25 1.34 (1.02-1.76) 0.034 --   --  
Co-morbidities       
   Immunosuppression 1.71 (1.46-2.02) <10-4 1.60 (1.35-1.91) <10-4 1.60 (1.35-1.89) <10-4
   Diabetes mellitus 1.04 (0.87-1.25) 0.63 --   --  
   Cirrhosis 1.60 (1.26-2.03) <10-4 1.20 (0.93-1.55) 0.148 --  
   Chronic heart failure (NYHA III/IV) 1.48 (1.17-1.86) 0.001 1.25 (0.96-1.63) 0.095 --  
Knaus (C/D vs. A/B) 1.70 (1.45-2.00) <10-4 1.38 (1.15-1.65) <10-4 1.49 (1.26-1.74) <10-4
SOFA 1.23 (1.20-1.26) <10-4 1.23 (1.20-1.27) <10-4 1.24 (1.21-1.27) <10-4
Site of infection       
   Respiratory tract 1.00 (0.86-1.18) 0.952 --   --  
   Abdominal 1.02 (0.83-1.26) 0.831 --   --  
   Renal/urinary tract 0.61 (0.47-0.79) <10-4 0.65 (0.49-0.85) 0.001 0.62 (0.48-0.81) <10-4
   Bloodstream 1.39 (1.11-1.73) 0.004 1.23 (0.97-1.56) 0.084 --  
   Other 1.00 (0.72-1.41) 0.978 --   --  
Nosocomial vs. community infection 1.42 (1.20-1.67) <10-4 1.15 (0.97-1.36) 0.102 --  
Germ identification (yes vs. no) 0.88 (0.75-1.04) 0.141 0.85 (0.71-1.02) 0.078 --  
Type of admission (surgery vs. medical) 0.68 (0.53-0.87) 0.002 --   --  
Origin (transfer vs. home/nursing home) 1.49 (1.25-1.77) <10-4 --   --  
  1. BMI, body mass index; CI, confidence interval; HR, hazard ratio; NYHA, New York Heart Association; SOFA, Sepsis-related Organ Failure Assessment.