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Table 5 Factors associated with time to mortality, right censored at 28 days, by the Cox model in the study population of 1,488 patients with septic shock (EPISS study - 2009 to 2011).

From: The epidemiology of septic shock in French intensive care units: the prospective multicenter cohort EPISS study

 

Univariate Cox models

Full Cox model

Final Cox model

 

HR (95%CI)

P

HR (95%CI)

P

HR (95%CI)

P

Age (per additional 10 years)

1.19 (1.13-1.28)

<10-4

1.27 (1.19-1.36)

<10-4

1.27 (1.18-1.36)

<10-4

Females (vs. males)

0.85 (0.72-1.01)

0.062

0.99 (0.84-1.18)

0.942

--

 

BMI (kg/m²)

      

   <20 vs. 20.25

1.08 (0.79-1.46)

0.641

--

 

--

 

   25-30 vs. 20-25

0.94 (0.76-1.18)

0.614

--

 

--

 

   >30 vs. 20-25

0.86 (0.68-1.09)

0.222

--

 

--

 

   Unknown vs. 20-25

1.34 (1.02-1.76)

0.034

--

 

--

 

Co-morbidities

      

   Immunosuppression

1.71 (1.46-2.02)

<10-4

1.60 (1.35-1.91)

<10-4

1.60 (1.35-1.89)

<10-4

   Diabetes mellitus

1.04 (0.87-1.25)

0.63

--

 

--

 

   Cirrhosis

1.60 (1.26-2.03)

<10-4

1.20 (0.93-1.55)

0.148

--

 

   Chronic heart failure (NYHA III/IV)

1.48 (1.17-1.86)

0.001

1.25 (0.96-1.63)

0.095

--

 

Knaus (C/D vs. A/B)

1.70 (1.45-2.00)

<10-4

1.38 (1.15-1.65)

<10-4

1.49 (1.26-1.74)

<10-4

SOFA

1.23 (1.20-1.26)

<10-4

1.23 (1.20-1.27)

<10-4

1.24 (1.21-1.27)

<10-4

Site of infection

      

   Respiratory tract

1.00 (0.86-1.18)

0.952

--

 

--

 

   Abdominal

1.02 (0.83-1.26)

0.831

--

 

--

 

   Renal/urinary tract

0.61 (0.47-0.79)

<10-4

0.65 (0.49-0.85)

0.001

0.62 (0.48-0.81)

<10-4

   Bloodstream

1.39 (1.11-1.73)

0.004

1.23 (0.97-1.56)

0.084

--

 

   Other

1.00 (0.72-1.41)

0.978

--

 

--

 

Nosocomial vs. community infection

1.42 (1.20-1.67)

<10-4

1.15 (0.97-1.36)

0.102

--

 

Germ identification (yes vs. no)

0.88 (0.75-1.04)

0.141

0.85 (0.71-1.02)

0.078

--

 

Type of admission (surgery vs. medical)

0.68 (0.53-0.87)

0.002

--

 

--

 

Origin (transfer vs. home/nursing home)

1.49 (1.25-1.77)

<10-4

--

 

--

 
  1. BMI, body mass index; CI, confidence interval; HR, hazard ratio; NYHA, New York Heart Association; SOFA, Sepsis-related Organ Failure Assessment.