Table 1 Baseline characteristics of the study population of 1,488 intensive care unit patients with septic shock, and survival probabilities at 3, 7, and 28 days (Kaplan-Meier product limit method - EPISS study - 2009 to 2011).

Age (years)

   <60

428 (28.8%)

86.0%

79.9%

67.8%

<0.0001

   60 to <70

277 (25.3%)

82.2%

74.8%

57.8%

   70 to <80

437 (29.4%)

80.3%

75.0%

54.1%

   ≥80

246 (16.5%)

78.0%

71.1%

45.7%

Gender

   Female

537 (36.1%)

82.7%

76.7%

61.6%

0.04

   Male

951 (63.9%)

81.7%

75.2%

55.4%

BMI (kg/m²)

   <20

129 (8.7%)

81.4%

74.4%

55.5%

0.06

   20-25

371 (24.9%)

83.0%

77.0%

56.4%

   25-30

388 (26.1%)

82.0%

77.8%

59.0%

   >30

336 (22.6%)

85.7%

79.1%

61.4%

   N/A

264 (17.7%)

Co-morbidities^b

   Immunosuppression^c

459 (30.9%)

76.7%

66.6%

44.9%

<0.0001

Cancer (solid tumors)

226 (49.2%)

77.9%

68.4%

44.5%

0.97

Hematological cancer

142 (30.9%)

69.0%

57.0%

37.0%

<0.01

Corticoids

109 (23.8%)

79.8%

71.6%

52.9%

0.55

Transplantation

40 (8.7)

82.5%

77.5%

55.0%

0.15

AIDS

10 (2.2%)

80.0%

70.0%

30.0%

0.63

Other

77 (16.8%)

74.0%

64.0%

48.0%

0.90

   Diabetes mellitus

387 (26.0%)

84.7%

77.7%

55.8%

0.63

   Cirrhosis

133 (8.9%)

79.7%

66.8%

41.7%

<0.0001

   Chronic heart failure (NYHA Class III/IV)

160 (10.8%)

78.1%

72.5%

46.1%

<0.01

   Chronic respiratory failure^c

113 (7.6%)

86.7%

81.4%

57.9%

0.80

   Chronic renal failure^d

171 (11.6%)

81.5%

75.7%

49.4%

0.04

Number of co-morbidities

   None

510 (34.3%)

85.5%

81.4%

70.0%

<0.0001

   1

633 (42.5%)

80.1%

73.1%

54.7%

   2 or more

339 (23.1%)

80.6%

72.1%

44.7%

Knaus^c

   A/B

853 (57.4%)

85.5%

80.3%

65.0%

<0.0001

   C/D

634 (42.6%)

77.4%

69.5%

47.6%

SOFA

   ≥11

823 (55.3%)

72.5%

65.6%

45.0%

<0.0001

   <11

665 (44.7%)

93.8%

88.3%

73.3%

SAPS II

   ≥56

753 (50.6%)

69.3%

61.3%

40.9%

<0.0001

   <56

735 (49.4%)

95.1%

90.4%

74.8%

Site of infection^b

   Respiratory tract

798 (53.6%)

84.1%

77.4%

56.7%

0.84

   Abdominal

285 (19.2%)

83.1%

75.0%

58.2%

0.83

   Renal/urinary tract

209 (14.1%)

86.6%

82.8%

69.5%

<0.001

   Bloodstream

196 (13.2%)

70.4%

63.3%

49.8%

<0.001

   Other

88 (5.9%)

81.8%

75.0%

57.3%

0.99

Type of infection

   Community-acquired

974 (65.5%)

82.6%

78.1%

61.9%

<0.0001

   Nosocomial

514 (34.5%)

80.9%

71.2%

49.6%

Germ identification

   Yes

1,000 (67.2%)

81.8%

75.9%

58.8%

0.21

   No

488 (32.8%)

82.6%

75.4%

55.2%

Type of admission

   Planned surgery

37 (2.5%)

89.2%

83.8%

64.2%

<0.01

   Medical

1,248 (83.9%)

80.7%

74.2%

55.9%

   Emergency surgery

203 (13.6%)

89.2%

83.2%

67.3%

Origin of patient

595 (40.0%)

   Home

23 (1.6%)

84.0%

79.1%

65.3%

<0.0001

   Nursing home

870 (58.5%)

95.6%

91.3%

73.9%

   Transfer

80.3%

73.0%

51.9%