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Table 4 Performance of the studied variables in the diagnosis of bacteremic systemic inflammatory response syndrome (SIRS)

From: Impact of interleukin-10, soluble CD25 and interferon-γ on the prognosis and early diagnosis of bacteremic systemic inflammatory response syndrome: a prospective observational study

Variable

Parameter

D-1 values (95% CI)

D-7 values (95% CI)

IL-10

AUROCC

0.767 (0.601, 0.888)

0.753 (0.579, 0.883)

 

AUROCC significance

P = 0.0021

P = 0.0016

 

Cutoff

3.05

0.59

 

Sensitivity

78.26 (56.3, 92.5)

66.67 (43.0, 85.4)

 

Specificity

80.0 (51.9, 95.7)

71.43 (41.9, 91.6)

 

Positive likelihood ratio

3.91 (2.8, 5.5)

2.33 (1.5, 3.7)

 

Negative likelihood ratio

0.27 (0.08, 1.0)

0.47 (0.2, 1.3)

sCD25

AUROCC

0.812 (0.544, 0.960)

0.785 (0.523, 0.943)

 

AUROCC significance

P = 0.0095

P = 0.0201

 

Cutoff

19.9

22.1

 

Sensitivity

87.5 (47.3, 99.7)

87.5 (47.3, 99.7)

 

Specificity

75.0 (34.9, 96.8)

77.78 (40.0, 97.2)

 

Positive likelihood ratio

3.5 (2.2, 5.6)

3.94 (2.5, 6.1)

 

Negative likelihood ratio

0.17 (0.02, 1.5)

0.16 (0.02, 1.5)

IFN-γ

AUROCC

0.486 (0.266, 0.711)

0.745 (0.504, 0.910)

 

AUROCC significance

P = 0.9204

P = 0.0342

 

Cut-off

9.0

1.8

 

Sensitivity

45.45 (16.7, 76.6)

60.0 (26.2, 87.8)

 

Specificity

70.0 (34.8, 93.3)

90.0 (55.5, 99.7)

 

Positive likelihood ratio

1.52 (0.7, 3.3)

6.0 (3.5, 10.4)

 

Negative likelihood ratio

0.78(0.3-2.3)

0.44 (0.06-3.3)

PCT

AUROCC

0.800 (0.641, 0.911)

0.781(0.612, 0.901)

 

AUROCC significance

P = 0.0001

P = 0.0011

 

Cutoff

0.24

0.32

 

Sensitivity

91.3 (72.0, 98.9)

95.24 (76.2, 99.9)

 

Specificity

62.5 (35.4, 84.8)

60.0 (32.3, 83.7)

 

Positive likelihood ratio

2.43 (1.6, 3.6)

2.38 (1.6, 3.6)

 

Negative likelihood ratio

0.14 (0.03, 0.6)

0.079 (0.01, 0.6)

CRP

AUROCC

0.56 (0.392, 0.718)

0.58 (0.407, 740)

 

AUROCC significance

P = 0.5276

P = 0.4055

 

Cutoff

137

125

 

Sensitivity

39.13 (19.7, 61.5)

50.0 (28.2, 71.8)

 

Specificity

87.5 (61.7, 98.4)

80.0 (51.9, 95.7

 

Positive likelihood ratio

3.13 (1.8, 5.4)

2.50 (1.5, 4.1)

 

Negative likelihood ratio

0.70 (0.2, 2.6)

0.62 (0.2, 1.9)

  1. Diagnostic accuracy of IL-10, sCD25, IFN-γ, procalcitonin (PCT) and C-reactive protein (CRP) evaluated by receiver-operating characteristics (ROC) analysis carried out on samples obtained at the time of hospital presentation (D-1) and at the end of the first week of the hospital stay (D-7), to estimate the pro- and anti-inflammatory mediators as diagnostic markers of bacteremic SIRS in critically ill patients. AUROCC, area under the ROC curve.
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Critical Care

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