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Table 4 Performance of the studied variables in the diagnosis of bacteremic systemic inflammatory response syndrome (SIRS)

From: Impact of interleukin-10, soluble CD25 and interferon-γ on the prognosis and early diagnosis of bacteremic systemic inflammatory response syndrome: a prospective observational study

Variable Parameter D-1 values (95% CI) D-7 values (95% CI)
IL-10 AUROCC 0.767 (0.601, 0.888) 0.753 (0.579, 0.883)
  AUROCC significance P = 0.0021 P = 0.0016
  Cutoff 3.05 0.59
  Sensitivity 78.26 (56.3, 92.5) 66.67 (43.0, 85.4)
  Specificity 80.0 (51.9, 95.7) 71.43 (41.9, 91.6)
  Positive likelihood ratio 3.91 (2.8, 5.5) 2.33 (1.5, 3.7)
  Negative likelihood ratio 0.27 (0.08, 1.0) 0.47 (0.2, 1.3)
sCD25 AUROCC 0.812 (0.544, 0.960) 0.785 (0.523, 0.943)
  AUROCC significance P = 0.0095 P = 0.0201
  Cutoff 19.9 22.1
  Sensitivity 87.5 (47.3, 99.7) 87.5 (47.3, 99.7)
  Specificity 75.0 (34.9, 96.8) 77.78 (40.0, 97.2)
  Positive likelihood ratio 3.5 (2.2, 5.6) 3.94 (2.5, 6.1)
  Negative likelihood ratio 0.17 (0.02, 1.5) 0.16 (0.02, 1.5)
IFN-γ AUROCC 0.486 (0.266, 0.711) 0.745 (0.504, 0.910)
  AUROCC significance P = 0.9204 P = 0.0342
  Cut-off 9.0 1.8
  Sensitivity 45.45 (16.7, 76.6) 60.0 (26.2, 87.8)
  Specificity 70.0 (34.8, 93.3) 90.0 (55.5, 99.7)
  Positive likelihood ratio 1.52 (0.7, 3.3) 6.0 (3.5, 10.4)
  Negative likelihood ratio 0.78(0.3-2.3) 0.44 (0.06-3.3)
PCT AUROCC 0.800 (0.641, 0.911) 0.781(0.612, 0.901)
  AUROCC significance P = 0.0001 P = 0.0011
  Cutoff 0.24 0.32
  Sensitivity 91.3 (72.0, 98.9) 95.24 (76.2, 99.9)
  Specificity 62.5 (35.4, 84.8) 60.0 (32.3, 83.7)
  Positive likelihood ratio 2.43 (1.6, 3.6) 2.38 (1.6, 3.6)
  Negative likelihood ratio 0.14 (0.03, 0.6) 0.079 (0.01, 0.6)
CRP AUROCC 0.56 (0.392, 0.718) 0.58 (0.407, 740)
  AUROCC significance P = 0.5276 P = 0.4055
  Cutoff 137 125
  Sensitivity 39.13 (19.7, 61.5) 50.0 (28.2, 71.8)
  Specificity 87.5 (61.7, 98.4) 80.0 (51.9, 95.7
  Positive likelihood ratio 3.13 (1.8, 5.4) 2.50 (1.5, 4.1)
  Negative likelihood ratio 0.70 (0.2, 2.6) 0.62 (0.2, 1.9)
  1. Diagnostic accuracy of IL-10, sCD25, IFN-γ, procalcitonin (PCT) and C-reactive protein (CRP) evaluated by receiver-operating characteristics (ROC) analysis carried out on samples obtained at the time of hospital presentation (D-1) and at the end of the first week of the hospital stay (D-7), to estimate the pro- and anti-inflammatory mediators as diagnostic markers of bacteremic SIRS in critically ill patients. AUROCC, area under the ROC curve.