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Table 1 Patients' characteristics and univariate analysis of factors associated with hospital mortality

From: Clinical outcomes of patients requiring ventilatory support in Brazilian intensive care units: a multicenter, prospective, cohort study

Characteristic All patients
(n= 773)
Survivors
(n= 451)
Non-survivors
(n= 322)
OR (CI 95%) P-value
General      
Age - yo 62 (43 to 76) 58 (35 to 72) 69 (53 to 80) 1.03 (1.02 to 1.04) < 0.001
Male gender - n (%) 435 (56) 260 (58) 175 (54) 0.87 (0.66 to 1.17) 0.362
Ideal weight - Kg 61 (52 to 69) 62 (54 to 71) 61 (52 to 67) 0.98 (0.97 to 0.99) 0.034
Admission SAPS 3 score (points) 62 (52 to 72) 58 (49 to 67) 68 (57 to 77) 1.04 (1.03 to 1.06) < 0.001
SOFA score on Day 1 (points) 8 (5 to 10) 7 (4 to 9) 8 (7 to 11) 1.17 (1.12 to 1.23) < 0.001
SOFA score excluding respiratory component (points) 6 (4 to 8) 5 (3 to 8) 7 (5 to 9) 1.18 (1.13 to 1.24) < 0.001
Charlson Comorbidity Index (points)      
   0 314 (41) 227 (50) 87 (27) Ref.  
   1 to 2 288 (37) 160 (36) 128 (40) 0.23 (0.15 to 0.34) < 0.001
   > 2 171 (22) 64 (14) 107 (33) 0.48 (0.33 to 0.70)  
LOS prior ICU - days 1 (0 to 3) 1 (0 to 2) 1 (0 to 4) 1.03 (1.01 to 1.05) 0.009
Admission source      
Ward - n (%) 242 (31) 119 (26) 122 (38) Ref.  
Emergency room - n (%) 367 (47) 225 (50) 142 (44) 0.62 (0.45 to 0.86) 0.004
Operation room - n (%) 164 (22) 107 (24) 58 (18) 0.54 (0.36 to 0.81) 0.003
Admission Diagnosis      
Pneumonia - n (%) 207 (27) 111 (25) 96 (30) 0.63 (0.32 to 1.23) 0.177
Neurological - n (%) 146 (19) 73 (16) 73 (23) 0.70 (0.41 to 1.22) 0.210
Non-pulmonary sepsis - n (%) 90 (12) 41 (9) 49 (15) 0.77 (0.49 to 1.19) 0.238
Asthma/COPD - n (%) 50 (6) 33 (7) 17 (5) Ref.  
Cardiogenic pulmonary edema - n (%) 43 (6) 24 (5) 19 (6) 0.86 (0.42 to 1.75) 0.681
Extracranial trauma - n (%) 41 (5) 24 (5) 17 (5) 1.22 (0.76 to 1.95) 0.415
Hypovolemic/cardiogenic shock - n (%) 37 (5) 23 (5) 14 (4) 0.64 (0.27 to 1.55) 0.326
Aspirative syndromes - n (%) 26 (3) 17 (4) 9 (4) 0.96 (0.48 to 1.92) 0.915
Others - n (%) 133 (17) 73 (16) 60 (18) 0.74 (0.34 to 1.56) 0.431
Comorbidities      
Hypertension - n (%) 328 (42) 167 (37) 161 (50) 1.71 (1.28 to 2.29) < 0.001
Diabetes - n (%) 177 (23) 81 (18) 96 (30) 1.95 (1.39 to 2.73) < 0.001
Heart failure - n (%) 67 (9) 27 (6) 40 (12) 2.23 (1.34 to 3.73) 0.002
Chronic renal failure - n (%) 51 (7) 16 (4) 35 (11) 3.32 (1.80 to 6.10) < 0.001
Chronic renal failure in dialysis n (%) 15 (2) 7 (2) 8 (2) 1.62 (0.58 to 4.50) 0.359
Neoplasm - n (%) 162 (21) 66 (15) 96 (30) 1.91 (1.38 to 2.65) < 0.001
AIDS - n (%) 13 (2) 7 (2) 6 (2) 1.21 (0.40 to 3.63) 0.736
COPD - n (%) 80 (10) 47 (10) 33 (10) 0.98 (0.61 to 1.57) 0.938
Ventilatory support category      
Successful NIV - n (%) 70 (9) 57 (13) 13 (4) Ref.  
NIV failure - n (%) 81 (10) 40 (8) 41 (13) 4.49 (2.14 to 9.45) < 0.001
Invasive MV - n (%) 622 (80) 354 (78) 268 (82) 3.32 (1.78 to 6.19) < 0.001
Respiratory Data at first day      
Pressure controlled mode - n (%) 371 (48) 208 (34) 163 (27) 1.09 (0.79 to 1.51) 0.603
Volume controlled mode - n (%) 186 (24) 104 (17) 82 (13) 1.06 (0.75 to 1.49) 0.742
Pressure support mode - n (%) 54 (7) 34 (6) 20 (3) 0.76 (0.42 to 1.35) 0.349
Tidal volume (ideal weight) - mL/kg 7.5 (6.1 to 8.7) 7.3 (6.0 to 8.7) 7.5 (6.6 to 8.9) 1.00 (0.90 to 1.11) 0.992
Plateau pressure - cmH2O 20 (17 to 24) 20 (17 to 24) 20 (16 to 24) 0.99 (0.95 to 1.04) 0.746
PEEP - cmH2O 6 (5 to 8) 6 (5,8) 6 (5 to 8) 0.95 (0.87 to 1.03) 0.206
PaO2/FiO2 ratio 257 (185 to 330) 260 (196 to 346) 250 (167 to 316) 0.99 (0.99 to 1.00) 0.014
ARDS - n (%) 242 (31) 116 (26) 126 (39) 1.50 (1.06 to 2.12) 0.021
Length of ventilatory support - days 5 (3 to 10) 5 (2 to 8) 6 (3 to 12) 1.02 (1.01 to 1.04) 0.005
Support during ICU stay      
RRT - n (%) 148 (19) 47 (10) 101 (31) 3.91 (2.67 to 5.75) < 0.001
Vasopressors - n (%) 521 (67) 265 (60) 256 (79) 2.83 (2.02 to 3.98) < 0.001
Cumulative fluid balance (72 h) - L 2.9 (0.8 to 5.4) 2.6 (0.8 to 4.6) 3.7 (1.1 to 6.2) 1.05 (1.01 to 1.10) 0.011
Outcomes      
ICU mortality - n (%) 260 (34) ----------- ----------- ----------- ----------
Hospital mortality - n (%) 322 (42) ----------- ----------- ----------- ----------
ICU LOS - days 10 (6 to 18) 10 (6 to 17) 10 (5 to 19) 1.01 (1.00 to 1.02) 0.047
Hospital LOS - days 20 (11 to 34) 23 (14 to 36) 16 (7 to 30) 0.99 (0.98 to 0.99) 0.009
  1. Abbreviations: AIDS, Acquired Immunodeficiency Syndrome; ARDS, Acute Respiratory Distress Syndrome; COPD, Chronic Obstructive Pulmonary Disease; ICU, Intensive care unit; LOS, Length-of-stay; MV, Mechanical ventilation; NIV, Non-invasive ventilation; PEEP, Positive End-Expiratory Pressure; RRT, Renal Replacement Therapy; SAPS, Simplified Acute Physiology Score; SOFA, Sequential Organ Failure Assessment.