Table 4 Diagnostic performance of biomarkers in distinguishing sepsis from non-infective SIRS in patients with organ dysfunction.
From: Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care
Marker | AUC (95% CI) | Cut off | Sensitivity | Specificity | PPV | NPV |
|---|---|---|---|---|---|---|
PCT | 0.84 (0.77 to 0.91) | 1.0 ng/ml | 74% | 81% | 86% | 67% |
PSP | 0.91 (0.86 to 0.96) | 30 ng/ml | 88% | 78% | 86% | 81% |
sCD25 | 0.87 (0.81 to 0.93) | 2.5 ng/ml | 80% | 78% | 85% | 72% |
HBP | 0.58 (0.48 to 0.68) | 50 ng/ml | 78% | 38% | 66% | 53% |
IL6 | 0.82 (0.74 to 0.89) | 200 pg/ml | 71% | 66% | 76% | 60% |
IL8 | 0.76 (0.68 to 0.84) | 80 pg/ml | 82% | 58% | 75% | 67% |
IL1β | 0.77 (0.69 to 0.85) | 1.0 pg/ml | 65% | 88% | 89% | 62% |