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Table 4 Diagnostic performance of biomarkers in distinguishing sepsis from non-infective SIRS in patients with organ dysfunction.

From: Sepsis biomarkers in unselected patients on admission to intensive or high-dependency care

Marker AUC (95% CI) Cut off Sensitivity Specificity PPV NPV
PCT 0.84 (0.77 to 0.91) 1.0 ng/ml 74% 81% 86% 67%
PSP 0.91 (0.86 to 0.96) 30 ng/ml 88% 78% 86% 81%
sCD25 0.87 (0.81 to 0.93) 2.5 ng/ml 80% 78% 85% 72%
HBP 0.58 (0.48 to 0.68) 50 ng/ml 78% 38% 66% 53%
IL6 0.82 (0.74 to 0.89) 200 pg/ml 71% 66% 76% 60%
IL8 0.76 (0.68 to 0.84) 80 pg/ml 82% 58% 75% 67%
IL1β 0.77 (0.69 to 0.85) 1.0 pg/ml 65% 88% 89% 62%
  1. Biomarker performance is shown for 76 patients with severe sepsis and 50 patients with non-infective SIRS and organ dysfunction. Data for GMCSF and TNFα are not shown as only a minority of patients had detectable levels of these markers.